This is a concise, practical, case-based book documenting examples and scenarios that will
help you manage challenging clinical issues for patients with myeloproliferative neoplasms.
The editors and authors have strived to distil the very latest information in this rapidly
advancing field in a way that will help you to update your practice and manage your
patients. The key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations
such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with MPN such as progression to acute
myeloid leukemia. This book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms,
such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell
disease, hypereosinophilia, MPN/MBS overlap syndromes and atypical CML, amongst others. This book is a practical reference for
practitioners, hematologists, medical oncologists and trainees.
Key Features
A useful guide for providers across the world managing patients with myeloproliferative neoplasms
The practical case-based approach makes this book particularly suitable for training individuals in the care of hematology patients,
from major cancer centers to community hematologists and medical oncologists
Provides detailed information about uncommon myeloproliferative neoplasms, for which there is little good clinical guidance in
existing literature
Contents
Preface;
1. Initial assessment of the undiagnosed patient who
has an erythrocytosis, leucocytosis or thrombocytosis;
2. Practical approaches to molecular testing and
diagnosis of mastocytosis, hypereosinophilia and
MDS/MPN overlap syndromes;
3. Incidental splenomegaly: an approach to
diagnosis;
4. When to do a bone marrow biopsy and how to
interpret it in the diagnosis of myeloproliferative
neoplasm;
5. Accurately assessing risk in your myeloproliferative
neoplasm patient;
6. Incorporating symptomatic assessment in
therapy choice for patients with myeloproliferative
neoplasms;
7. The newly diagnosed patient with essential
thrombocythemia;
8. The newly diagnosed patient with polycythemia
vera;
9. Longstanding polycythemia vera and essential
thrombocythemia: monitoring and management
goals;
10. Management of myelofibrosis: which patients
are candidates for JAK inhibitors and how to
manage patients on JAK inhibitor treatment;
11. Hematopoietic cell transplantation for
myelofibrosis: who and when?;
12. Systemic mast cell disease, diagnosis and
management;
13. Hypereosinophilia: an illustrated approach to
diagnosis and management;
14. Myelodysplastic/myeloproliferative neoplasm
overlap syndromes;
15. Atypical chronic myeloid leukemia and chronic
neutrophilic leukemia;
16. Women and children with myeloproliferative
neoplasms special considerations;
17. Conception and pregnancy in myeloproliferative
neoplasms;
18. Managing acute vascular events in patients with
myeloproliferative neoplasms;
19. Challenging thrombotic scenarios in the
myeloproliferative neoplasms: splanchnic vein
thrombosis and others;
20. Familial myeloproliferative neoplasms
implications for patients and their families;
21. Management of acute leukemia following
myeloproliferative neoplasms;
Index.