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Translational Research in Traumatic Brain Injury

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Features

Covers the spectrum of TBI, from mild sports-related injuries to severe blast injuries
Discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments
Describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder
Features chapters written by international leaders across multiple disciplines, including neurobiology, neurology, neurosurgery, intensive care medicine, psychiatry, and rehabilitative medicine
Summary

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow.

Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas:

Epidemiology
Pathophysiology
Diagnosis
Current treatment strategies and sequelae
Future therapies
Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Epidemiology
Peter Leo and Michael McCrea

Sport-Related Traumatic Brain Injury
Michael Clark and Kevin Guskiewicz

Diffuse Axonal Injury
Erik Su and Michael Bell

Blood-Brain Barrier Pathophysiology following Traumatic Brain Injury
Lulit Price, Christy Wilson, and Gerald Grant

Cellular and Molecular Mechanisms of Secondary Neuronal Injury following Traumatic Brain Injury
Kamesh Krishnamurthy and Daniel Laskowitz

Neuroinflammation
Finnian Hanrahan and Matthew Campbell

Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans
Christine E. Marx, Jennifer C. Naylor, Jason D. Kilts, Charlotte E. Dunn, Larry A. Tupler, Steven T. Szabo, Bruce P. Capehart, Rajendra A. Morey, Lawrence J. Shampine, and VA Mid-Atlantic MIRECC Workgroup

Neuroplasticity after Traumatic Brain Injury
YouRong Sophie Su, Annand Veeravagu, and Gerald Grant

Genetic Influences in Traumatic Brain Injury
Ellen R. Bennett, Karin Reuter-Rice, and Daniel T. Laskowitz

Modeling Post-Traumatic Epilepsy for Therapy Development
Giulia Curia, Clifford L. Eastman, John W. Miller, and Raimondo D’Ambrosio

Translational Principles of Neuroprotective and Neurorestorative Therapy Testing in Animal Models of Traumatic Brain Injury
Edward D. Hall

Biomarkers of Traumatic Brain Injury and Their Relationship to Pathology
Jin Zhang, Vikram Puvenna, and Damir Janigro

Advanced Neuroimaging of Mild Traumatic Brain Injury
Inga K. Koerte, Jakob Hufschmidt, Marc Muehlmann, Alexander P. Lin, and Martha E. Shenton

Epilepsy after Traumatic Brain Injury
Kan Ding, Puneet K. Gupta, and Ramon Diaz-Arrastia

Intracranial Pressure Monitoring and Management
Peter Le Roux

Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment
Jonathon R. Howlett and Murray B. Stein

Traumatic Brain Injury and Potential for Neuromodulation
Shivanand P. Lad

Enhanced Functional Outcome from Traumatic Brain Injury with Brain-Machine Interface Neuromodulation: Neuroprosthetic Scaling in Relation to Injury Severity
Dennis A. Turner

Neurocognitive and Psychiatric Symptoms following Mild Traumatic Brain Injury
Wesley R. Cole and Jason M. Bailie