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Covers the spectrum of TBI, from mild sports-related injuries to severe blast injuries Discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments Describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder Features chapters written by international leaders across multiple disciplines, including neurobiology, neurology, neurosurgery, intensive care medicine, psychiatry, and rehabilitative medicine Summary
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow.
Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas:
Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Epidemiology Peter Leo and Michael McCrea
Sport-Related Traumatic Brain Injury Michael Clark and Kevin Guskiewicz
Diffuse Axonal Injury Erik Su and Michael Bell
Blood-Brain Barrier Pathophysiology following Traumatic Brain Injury Lulit Price, Christy Wilson, and Gerald Grant
Cellular and Molecular Mechanisms of Secondary Neuronal Injury following Traumatic Brain Injury Kamesh Krishnamurthy and Daniel Laskowitz
Neuroinflammation Finnian Hanrahan and Matthew Campbell
Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans Christine E. Marx, Jennifer C. Naylor, Jason D. Kilts, Charlotte E. Dunn, Larry A. Tupler, Steven T. Szabo, Bruce P. Capehart, Rajendra A. Morey, Lawrence J. Shampine, and VA Mid-Atlantic MIRECC Workgroup
Neuroplasticity after Traumatic Brain Injury YouRong Sophie Su, Annand Veeravagu, and Gerald Grant
Genetic Influences in Traumatic Brain Injury Ellen R. Bennett, Karin Reuter-Rice, and Daniel T. Laskowitz
Modeling Post-Traumatic Epilepsy for Therapy Development Giulia Curia, Clifford L. Eastman, John W. Miller, and Raimondo DAmbrosio
Translational Principles of Neuroprotective and Neurorestorative Therapy Testing in Animal Models of Traumatic Brain Injury Edward D. Hall
Biomarkers of Traumatic Brain Injury and Their Relationship to Pathology Jin Zhang, Vikram Puvenna, and Damir Janigro
Advanced Neuroimaging of Mild Traumatic Brain Injury Inga K. Koerte, Jakob Hufschmidt, Marc Muehlmann, Alexander P. Lin, and Martha E. Shenton
Epilepsy after Traumatic Brain Injury Kan Ding, Puneet K. Gupta, and Ramon Diaz-Arrastia
Intracranial Pressure Monitoring and Management Peter Le Roux
Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment Jonathon R. Howlett and Murray B. Stein
Traumatic Brain Injury and Potential for Neuromodulation Shivanand P. Lad
Enhanced Functional Outcome from Traumatic Brain Injury with Brain-Machine Interface Neuromodulation: Neuroprosthetic Scaling in Relation to Injury Severity Dennis A. Turner
Neurocognitive and Psychiatric Symptoms following Mild Traumatic Brain Injury Wesley R. Cole and Jason M. Bailie
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