The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy.
The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated
The first two sections cover the background to, and principles of, treatment in different clinical situations
Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects
Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach
This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
Contents
List of Contributors
Preface to the Fourth Edition
Historical Introduction: The Drug Treatment of Epilepsy From 1857 to 2015
Simon Shorvon

Section 1 Introduction (Lead editor: Simon Shorvon)

1 Classification, aetiology, and investigation of epilepsy
Simon Shorvon
2 Differential Diagnosis of Epilepsy
Mark Cook
3 Epileptogenesis and its prevention
Giuliano Avanzini, Silvana Franceschetti
4 Antiepileptic Drug Discovery
H. Steve White, Melissa Barker-Haliski
5 Antiepileptic drug development
Dieter Schmidt
6 Mechanisms of Antiepileptic Drug Action
Matthew C. Walker, Rainer Surges
7 Mechanisms of Tolerance and Drug Resistance
Wolfgang Löscher, Dieter Schmidt
8 Epilepsy Biomarkers
Asla Pitkänen, Jerome Engel Jr

Section 2 - Principles of Medical Management (Lead Ed: Simon Shorvon)

9 General Principles of Medical Management
Emilio Perucca
10 Pharmacokinetic optimisation of therapy
Svein Johannessen, Cecilie Johannessen-Landmark, Emilio Perucca
11 Clinical approaches to management of adult epilepsy
Simon Shorvon
12 Management of Epilepsy in Remission
Patrick Kwan, Howan Leung, Xiaoting Hao
13 Management of Epilepsy in the first year of life
Elissa G. Yozawitz, Solomon L. Moshé
14 Management of Childhood Epilepsy Syndromes and epilepsy in specific diseases of childhood
Colin D. Ferrie
15 Management of epilepsy in people with learning disabilities
Eylert Brodtkorb
16 Management of Epilepsy in the Elderly
Hiba Arif, Lawrence J Hirsch
17 Emergency Treatment of Seizures and Status Epilepticus
Matthew C. Walker, Simon Shorvon
18 Management of medical co-morbidies associated with epilepsy
Gagandeep Singh
19 Management of psychiatric co-morbidities associated with epilepsy
Brent Elliott, Simon Shorvon
20 Prevention and Management of Side-effects of Antiepileptic Drugs
Gaetano Zaccara, Piero Perucca
21 Ketogenic and related diets
Eric H. Kossoff, Courtney A. Haney
22 Complementary and Alternative Treatments for Epilepsy
Sallie A. Baxendale
23 Reproductive Aspects of Epilepsy Treatment
Torbjörn Tomson
24 Genetic Counselling in Epilepsy
Federico Zara
25 Drug Interactions
Edoardo Spina, Domenico Italiano
26 Medical Treatment of Epilepsy in Situations with Limited Resources
Patrick Adjei

Section 3 - Antiepileptic Drugs (Lead editor: Emilio Perucca)

27 Introduction to the Choice of Antiepileptic Drugs
Emilio Perucca
28 Acetazolamide
Miri Y. Neufeld
29 Adrenocorticotropic Hormone and Corticosteroids
Federico Vigevano, Maria Roberta Cilio
30 Benzodiazepines used in epilepsy
Eugen Trinka, Francesco Brigo
31 Brivaracetam
Joseph D'Souza, Emilio Perucca
32 Carbamazepine
Torbjörn Tomson
33 Eslicarbazepine Acetate
Meir Bialer, Christian Elger
34 Ethosuximide
Tracy A. Glauser, Emilio Perucca
35 Felbamate
Ilo E. Leppik, James R. White
36 Gabapentin
Ernest R. Somerville, Andrew W. Michell, Arjune Sen
37 Lacosamide
Rajesh Sachdeo, Roopal Karia
38 Lamotrigine
Fumisuke Matsuo, Awais Riaz
39 Levetiracetam
Jacqueline A. French, Derek Chong
40 Oxcarbazepine
Edward Faught Jnr., Hyunmi Kim
41 Perampanel
Martin J. Brodie
42 Phenobarbital, Primidone and Other Barbiturates
Roberto Michelucci, Elena Pasini
43 Phenytoin
Mervyn J. Eadie
44 Piracetam
Simon Shorvon
45 Pregabalin
Philippe Ryvlin
46 Retigabine
Michel Baulac
47 Rufinamide
Victor Biton
48 Stiripentol
Tapani Keränen
49 Tiagabine
Reetta Kälviäinen
50 Topiramate
J. Helen Cross, Catherine J. Riney
51 Valproate
Anthony G. Marson, Graeme J. Sills
52 Vigabatrin
Günter Krämer, Gabriele Ch. Wohlrab
53 Zonisamide
Michel Baulac
54 Other Drugs Rarely Used
Martin Holtkamp
55 Drugs in Clinical Development
H. Steve White, Norman Delanty

Section 4 Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel Jr)

56 Overview of Surgical Treatment for Epilepsy
Jerome Engel Jr
57 Scalp EEG in the Epilepsy Surgery Evaluation
John M. Stern, Christine B. Baca
58 Invasive EEG in Presurgical Evaluation of Epilepsy
Dennis Spencer, Adithya Sivaraju
59 MEG in epilepsy surgery evaluation
Hermann Stefan, Paul Boon
60 MRI in the Presurgical Evaluation
Christian E. Elger, Bernd Weber
61 PET and SPECT in Presurgical Evaluation of Epilepsy
Karolien Goffin, Wim Van Paesschen
62 Special Neurophysiological Techniques
François Mauguière, Julien Jung
63 Neuropsychological Testing in Presurgical Evaluation
Marilyn Jones-Gotman, Gail L. Risse
64 Presurgical Psychiatric Evaluation
Andres M. Kanner
65 Mesial Temporal Lobe Surgery and Other Lobar Resections
Itzhak Fried, James W. Leiphart
66 Resective Surgery of Neoplasms
Gregory D. Cascino, Nicholas M. Wetjen
67 Resective Surgery of Vascular and Infective Lesions for Epilepsy
Christopher E Uff, Neil D Kitchen
68 Surgery of Developmental Anomalies Causing Epilepsy
Ahyuda Oh, Joshua J. Chern, Youssef G. Comair
69 Hemispheric operations for Epilepsy
Georg Dorfmüller, Christine Bulteau, Olivier Delalande
70 Corpus Callosotomy
David W. Roberts
71 Hypothalamic Hamartoma
John F. Kerrigan
72 Multiple subpial transection
Adriana Bermeo-Ovalle,Michael C. Smith
73 Awake Surgery for Epilepsy
Webster H. Pilcher
74 Epilepsy Surgery in Children
Jason S. Hauptman, Gary W. Mathern
75 Complications of Epilepsy Surgery
Charles E. Polkey
76 Anaesthesia for Epilepsy Surgery
Barbara M. Van de Wiele
77 Vagal Nerve Stimulation
Steven C. Schachter
78 Brain Stimulation for Epilepsy
Gregory K. Bergey, Robert S. Fisher
79 Non-Resective Approaches for Medically Intractable Epilepsy
Thomas J. Gianaris, Andrea G. Scherer,Nicholas M. Barbaro
80 Future focal treatments for epilepsy
Hannah Cock, Laura Mantoan Ritter
81 Epilepsy Surgery in Countries with Limited Resources
Andre Palmini, Kurupath Radhakrishnan
Index