Contributors.
Preface.

1 Transfusion in the New Millennium: Ennio C. Rossi and Toby L. Simon.

Section I. Blood Components and Derivatives.

Part I. Red Blood Cells.

2 Red Cell Production and Kinetics: Mark J. Koury.

3 Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes: Christopher P. Stowell.

4 Red Blood Cell Metabolism and Preservation: Bjarte G. Solheim and John R. Hess.

5 Red Cell Immunology and Compatibility Testing: W. John Judd.

6 Carbohydrate Blood Groups: Eldad A. Hod, Patrice Spitalnik and Steven L. Spitalnik.

7 Rh and LW Blood Groups: Connie M. Westhoff and Don L. Siegel.

8 Other Protein Blood Groups: Petr Jarolim.

9 Anemia and Red Blood Cell Transfusion: Jeffrey L. Carson and Paul C. Hébert.

Part II. Platelets.

10 Platelet Production, Kinetics, and Hemostasis: Henry M. Rinder and Aaron Tomer.

11 Platelet Immunology and Alloimmunization: Brian R Curtis and Janice G. McFarland.

12 Preparation, Preservation, and Storage of Platelet Concentrates: Ralph R. Vassallo, Jr.

13 Thrombocytopenia and Platelet Transfusio: Peter W. Marks.

Part III. White Blood Cells.

14 Neutrophil Production and Kinetics: Neutropenia and Neutrophilia: Thomas H. Price.

15 Neutrophil Collection and Transfusion: Ronald G. Strauss.

16 Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects: Darrell J. Triulzi and Walter H. Dzik.

Part IV. Plasma.

17 Composition and Mechanisms of Blood Coagulation and Fibrinolysis: Peter Hellstern.

18 Immunoglobulins: Urs E. Nydegger.

19 Preparation and Use of Plasma Derivatives: Toby L. Simon, Kirsten Seidel and Albrecht Gröner.

20 Plasma Transfusion and Use of Albumin: Simon J. Stanworth and Alan T. Tinmouth.

Part V. Cell Kinetics.

21 Applications of Cellular Radiolabeliing in Transfusion Medicine: Larry J. Dumont, James P. AuBuchon and Richard J. Davey).

Section II. Clinical Practice.

Part I. Medical Patients.

22 Autoimmune Hemolytic Anemia and Paroxysmal Noctural Hemoglobinuria: Thomas P. Duffy.

23 Management of Immune Thrombocytopenias: Donald M. Arnold, James W. Smith and Theodore Warkentin.

24 Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy: Thomas J. Raife, Jeffry S. Rose and Steven R. Lentz.

Part II. Obstetric and Pediatric Patients.

25 Fetal and Neonatal Hematopoiesis: Robert D. Christensen and Martha C. Sola-Visner.

26 Obstetric Transfusion Practice: Humphrey H.H. Kanhai, Jos J.M. van Roosmalen and Anneke Brand.

27 Hemolytic Disease of the Newborn: Bjarte G. Solheim and Morten Grönn.

28 Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics: Linda J. Butros and Prasad Mathew.

29 Management of Congenital Hemolytic Anemias: Bruce I. Sharon.

30 Blood Component Transfusions for Infants: Ronald G. Strauss.

Part III. Oncology Patients.

31 Transfusion Support for the Oncology Patient: Christopher A. Tormey and Edward L. Snyder.

32 Hematopoietic Growth Factors (Cytokines): W. Conrad Liles and David C. Dale.

33 Hematopoietic Progenitor Cells: Biology and Processing: Thomas Leemhuis and Ronald A. Sacher.

34 Hematopoietic Progenitor Cells: Autologous Transplantation: Hooman H. Rashidi and Scott D. Rowley.

35 Hematopoietic Progenitor Cells: Allogeneic Transplantation: Amin M. Alousi and Sergio A. Giralt.

36Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation: Suhag H. Parikh and Joanne Kurtzberg.

Part IV. Surgery Patients.

37 Alternatives to Transfusion: Perioperative Blood Management: Lynne Uhl.

38 Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures: Walter H Dzik.

39 Transfusion Therapy in the Care of Trauma and Burn Patients: Ellen C. Omi and Richard L. Gamelli.

40 Transfusion Therapy in Solid-Organ Transplantation: Glenn Ramsey.

Section III. Apheresis.

41 Apheresis: Principles and Technology of Hemapheresis: Ronald O. Gilcher and James W. Smith.

42 Therapeutic Plasma Exchange Bruce C. McLeod.

43 Specialized Therapeutic Hemapheresis and Phlebotomy: Robert Weinstein.

Section IV. Hazards of Transfusion.

Part I - Hemovigilance.

44 Overview of Hemovigilance: Dorothy Stainsby, Jean-Claude Faber and Jan J rgensen.

45 Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Tranfusion: Eleftherios C. Vamvakas, José O. Bordin and Morris A. Blajchman.

Part II. Infectious Hazards of Transfusion.

46 Transfusion-Transmitted Hepatitis: Harvey J. Alter and Juan I. Esteban-Mur.

47 Retroviruses and Other Viruses: John A. J. Barbara and Brian Dow.

48 Transfusion Transmission of Parasites: Bryan R. Spencer.

49 Bacterial Contamination of Blood Products: Yara A. Park and Mark E. Brecher.

50 Prion Diseases: Marc L. Turner.

51 Pathogen Inactivation: Bjarte G. Solheim and Jerard Seghatchian.

Part III - Noninfectious Hazards.

52 Hemolytic Transfusion Reactions: Robertson D. Davenport.

53 Febrile, Allergic, and Nonimmune Transfusion Reactions: Gregory J. Pomper.

54 Transfusion-Associated Graft-vs-Host Disease: John E. Levine and James L. M. Ferrara.

55 Tranfusional Iron Overload: Sujit Sheth.

56 Transfusion-Related Acute Lung Injury: Jonathan P. Wallis and Ulrich J. H. Sachs.

Section V. Cell and Tissue Therapy.

57 HLA Antigens and Alleles: Thomas M. Williams.

58 Tissue Banking: Jeanne V. Linden, William F. Zaloga and A. Bradley Eisenbrey.

59 Adoptive Immunotherapy: Catherine M. Bollard and Helen Heslop.

60 Gene Therapy in Transfusion Medicine: Emanuela M. Bruscia and Diane S. Krause.

61 Tissue Engineering and Regenerative Medicine: Clay Quint and Laura Niklason.

Section VI. Delivery of Transfusion and Transplantation Services.

62 Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood: Kendall P Crookston, Susan L. Wilkinson and Toby L. Simon.

63 Current Legal Issues in Transfusion Medicine: Edward M. Mansfield, Thomas K. Berg, Kurt A. Leiheit, John Parker Sweeny and P. Robert Rigney.

64 Current Good Manufacturing Practice: P Ann Hoppe and Sheryl A. Kochman.

65 Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs: Dennis L. Confer.

66 Hospital Transfusion Committee and Quality Assurance: Pamela Clark and Paul D. Mintz.

Index.

Companion PC and Mac Compatible CD-ROMs.

CD-ROM 1: All chapters of the book with a full text search function.

CD-ROM 2: Cases.

1 Posttransfusion Hemolysis: Marian Petrides and Nicole A. Pele.

2 Child with Low Fibrinogen: Marian Petrides and Donna Castellone.

3 Head Injury, Sudden Dyspnea: Marian Petrides.

4 A Transfusion Fatality: Marian Petrides.

5 Platelet Refractoriness: Marian Petrides.

6 An Unexpected Panagglutinin: Marian Petrides.

7 Postsurgical Bleeding: Marian Petrides.

8 Jehovah's Witness Surgery: Christopher P. Stowell and Marian Petrides.

9 Delayed Fever and Dark Urine: Marian Petrides.