INDICE: VOLUME ONE PART I: BASIC PRINCIPLES IN THE DIAGNOSIS AND MANAGEMENT OF INFECTIOUS DISEASES. Section A: Microbial Virulence Factors . A Molecular Perspective of Microbial Pathogenicity. Microbial Adherence. Toxins. Section B: Host Defense Mechanisms . Innate (General or Nonspecific) Host Defense Mechanisms. Human Genetics and Infection. Antibodies. Complement. Granulocytic Phagocytes. Cell-Mediated Immunity and Its Role in Host Defense Against Infectious Diseases. Evaluation of the Patient with Suspected Immunodeficiency. Section C:Epidemiology of Infectious Diseases . Principles (Includes Definitions). Global Epidemiology. New and Emerging Infectious Diseases. Section D: The Clinician and the Microbiology Laboratory. Section E: Anti-Infective Therapy . Principles of Anti-Infective Therapy. Mechanisms of Bacterial Antibiotic Resistance. Pharmacokinetics and Pharmacodynamics of Antimicrobial Agents. Penicillins. Cephalosporins. Other -Lactam Antibiotics. -Lactam Allergy. Fusidic Acid. Aminoglycosides. Tetracyclines and Chloramphenicol. Rifamycins. Metronidazole. Macrolides and Clindamycin. Vancomycin, Teicoplanin, and the Streptogramins: Quinupristin and Dalfopristin. Oxazolidinones. Sulfonamides and Trimethoprim. Quinolones. Urinary Tract Agents: Nitrofurantoin and Methenamine. Topical Antibacterials. Antimycobacterial Agents. Antifungal Agents. Antiviral Agents (Other than Antiretrovirals). Immunomodulators. Hyperbaric Oxygen. Antiparasitic Agents.Antimicrobial Management and Cost Containment. Outpatient Intravenous Antibiotic Therapy. Tables of Antimicrobial Agent Pharmacology. PART II: MAJOR CLINICAL SYNDROMES. Section A: Fever . Temperature Regulation and the Pathogenesis of Fever. Fever of Unknown Origin. The Acutely Ill Patient with Fever and Rash.Section B: Upper Respiratory Infections . The Common Cold. Pharyngitis. AcuteLaryngitis. Acute Laryngotracheobronchitis (Croup). Otitis Externa, Otitis Media, and Mastoiditis. Sinusitis. Epiglottitis. Infections of the Oral Cavity, Neck, and Head. Section C: Pleuropulmonary and Bronchial Infections . Acute Bronchitis. Chronic Bronchitis and Acute Infectious Exarcebations. Bronchiolitis. Acute Pneumonia. Pleural Effusion and Empyema. Lung Abscess. Chronic Pneumonia. Cystic Fibrosis. Section D: Urinary Tract Infection . Section E: Sepsis Syndrome. Section F: Peritonitis and Other Intra-Abdominal. Section G: Cardiovascular Infections . Endocarditis and Intravascular Infections. Infections of Prosthetic Valves and Intravascular Devices. Prophylaxis of Infective Endocarditis. Myocarditis and Pericarditis. Mediastinitis. Section H: Central Nervous System Infections . Anatomic Considerations in Central Nervous System Infections. Acute Meningitis. Chronic Meningitis. Encephalitis, Myelitis, and Neuritis. Brain Abscess. Subdural Empyema. Epidural Abscess. Suppurative Intracranial Phlebitis. Section I: Skin and Soft Tissue Infections . Cellulitis and Subcutaneous Tissue Infections. Myositis. Lymphadenitis and Lymphangitis. Section J: Gastrointestinal Infections and Food Poisoning . Principles and Syndromes of Enteric Infection. Esophagitis. Nausea, Vomiting, and Noninflammatory Diarrhea. Antibiotic-Associated Colitis. Inflammatory Enteritides. Enteric Fever and Other Causes of Abdominal Symptoms with Fever. Food-Borne Disease. Tropical Sprue.Whipple's Disease. Section K: Bone and Joint Infections . Infectious Arthritis. Osteomyelitis. Infections with Prostheses in Bones and Joints. Section L: Diseases of the Reproductive Organs and Sexually Transmitted Diseases . GenitalSkin and Mucous Membrane Lesions. Urethritis. Vulvovaginitis and Cervicitis. Infections of the Female Pelvis. Prostatitis, Epididymitis, and Orchitis. Section M: Eye Infections . Conjunctivitis. Keratitis. Endophthalmitis. PeriocularInfections. Section N: Hepatitis . Acute Viral Hepatitis. Chronic Hepatitis. Section O: Acquired Immunodeficiency Syndrome (AIDS) . Global Perspective. Epidemiology and Prevention of AIDS and HIV Infection. Detection of HIV-1 Infection. Immunology of HIV Infection. General Manifestations (Including Ophthalmologic, Cutaneous and Renal Disease). Pulmonary Manifestations of HIV. Gastrointestinal Disease. Neurologic Manifestations of HIV. Oncologic Disease. HIV Infection in Women. Pediatric HIV Infection. Antiretroviral Therapy of HIV Infection. Management of Opportunistic Infections Associated with HIV Infection. Vaccines for HIV Infection. Section P: Miscellaneous Syndromes . Chronic Fatigue Syndrome. Index. VOLUME TWO. PART III: INFECTIOUS DISEASES AND THEIR ETIOLOGIC AGENTS. Section A: Viral Diseases . Introduction to Viruses and Viral Diseases.DNA VIRUSES . Poxviridae . Introduction to Poxviridae. Vaccinia Virus (Cowpox). Variola (Smallpox) and Monkeypox Viruses. Parapoxviruses and Molluscum Contagiosum and Tanapox Viruses. Herpesviridae. Introduction to Herpesviridae. Herpes Simplex Virus. Varicella-Zoster Virus. Cytomegalovirus. Epstein-Barr Virus(Infectious Mononucleosis). Human Herpesvirus 6 and Human Herpesvirus 7. Human Herpesvirus Type 8 (Kaposi's Sarcoma-Associated Herpesvirus). Herpes B Virus. Adenoviridae. Adenovirus. Papovaviridae. Papillomaviruses. JC, BK, and OtherPolyomaviruses; Progressive Multifocal Leukoencephalopathy. Hepadnaviridae. Hepatitis B Virus and the Hepatitis D Virus. Parvoviridae. Parvovirus B 19. RNAVIRUSES . Reoviridae . Orthoreoviruses and Orbiviruses. Coltiviruses (Colorado Tick Fever). Rotavirus. Togaviridae. Alphaviruses (Eastern, Western and D Venezuelan Equine Encephalitis). Rubella Virus (German Measles). Flavaviridae. Flaviviruses (Yellow Fever, Dengue and St. Louis Encephalitis). Hepatitis C. Hepatitis G Virus and TT Virus. Coronaviridae. Coronaviruses. Paramyxoviridae. Parainfluenza Viruses. Mumps Virus. Respiratory Syncytical Virus. Measles Virus(Rubeola). Rhabdoviridae. Vesicular Stomatitis Virus and Related Viruses. Rabies Virus. Filoviridae. Filoviruses: Marburg and Ebola Viruses (Table Comparing Useful-Per Nejm Review). Orthomyxoviridae. Influenza Virus. Bunyaviridae. California Encephalitis, Hantavirus Pulmonary Syndrome, and Bunyavirid Hemorrhagic Fevers. Arenaviridae. Lymphocytic Choriomeningitis Virus, Lassa Virus, and The South American Hemorrhagic Fevers. Retroviridae. Type C Oncoviruses, Including Human T-Cell Lymphotropic Viruses I and II. Human Immunodeficiency Viruses. Picornaviridae. Introduction to Picornaviridae. Poliovirus. Coxsackieviruses, Echoviruses and Newer Enteroviruses. Hepatitis A Virus. Rhinovirus. Caliciviridae and Other Gastroenteritis Viruses . Norwalk Virus and Other Caliciviruses. Astroviruses Totoviruses, and Picobirnaviruses. Unclassified Viruses . Hepatitis E. Section B: Prion Diseases . Prions and Prion Diseases of the CentralNervous System (Transmissible Neurodegenerative Diseases). Section C: Chlamydial Diseases . Introduction to Chlamydial Diseases. Chlamydia Trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections). Chlamydia Psittaci (Psittacosis). Chlamydia Pneumoniae. Section D: Mycoplasma Diseases . Introduction to Mycoplasma Diseases. Mycoplasma Pneumoniae and Atypical Pneumonia. Ureaplasma Urealyticum, Mycoplasma Hominis, and Mycoplasma Genitalium. Section E: Rickettsioses and Ehrlichioses . Introduction to Rickettsioses and Ehrlichioses. Rickettsia Rickettsi and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers). Rickettsia Akari (Rickettsialpox). Coxiella Burnetti (Q Fever). Rickettsia Prowazekii (Epidemic or Louse-borne Typhus). Rickettsia Typhi (Murine Typhus). Orientia Tsutsugamushi (Scrub Typhus). Ehrlichia Chaffeensis (Human Monocytotropic Ehrlichiosis), Ehrlichia Phagocytophilia (Human Granulocytotropic Ehrlichiosis),and Other Ehrlichiae. Section F: Bacterial Diseases . Introduction to Bacterial Diseases. GRAM-POSITIVE COCCI. Staphylococcus aureus (Including Toxic ShockSyndrome). Staphylococcus Epidermidis and Other Coagulase-Negative Staphylococci. Classification of Streptococci. Streptococcus Pyogenes (Including Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis). Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis. Streptococcus Pneumoniae. Enterococcus Species, Streptococcus bovis and Leuconostoc species. Streptococcus Agalactiae (Group B Streptococcus). Viridians Streptococci and Groups C and G. Streptococcus Intermedius Group. GRAM-POSITIVE BACILLI. Corynebacterium Diphtheriae. Other Corynebacteria and Rhodococcus. Listeria Monocytogenes. Bacillus Anthracis (Anthrax). Other Bacillus Species. Erysipelothrix Rhusiopathiae. GRAM-NEGATIVE COCCI. Neisseria Meningitidis. Neisseria Gonorrhoeae. Moraxella (Branhamella) Catarrhalis and Other Gram-Negative Cocci. GRAM-NEGATIVE BACILLI. Vibrio Cholerae. Other Pathogenic Vibrios. Campylobacter jejuni and Related Species. Helicobacter Pylori and related Enterobacteriaceae. Pseudomonas Aeruginosa. Stenotrophomonas Maltophilia and Burkholderia Cepacia. Acinetobacter Species. Salmonella Species (Including Typhoid Fever). Shigella Species (Bacillary Dysentery). Haemophilus Influenzae. Haemophilus Species, Including Chancroid. Gardnerella Vaginalis and Mobiluncus Species. Brucella Species. Francisella Tularensis (Tularemia). Pasteurella Species. Yersinia Species (Including Plague). Bordetella Species. Streptobacillus Moniliformis (Rat-Bite Fever). Legionella Pneumophilia (Legionnaire's Disease). Other Legionella Species.Capnocytophaga. Bartonella Species, Including Cat Scratch Disease. Calymmatobacterium Granulomatis (Donovanosis, Granuloma Inguinale). Other Gram-Negative Bacilli. SPIROCHETES. Treponema Pallidum (Syphilis). Treponema Species (Yaws, Pinta, Bejel). Leptospira Species (Leptospirosis). Borrelia Species (RelapsingFever). Borrelia Burgdorferi (Lyme Disease, Lyme Borreliosis). Spirillum Minus (Rat-Bite Fever). ANAEROBIC BACTERIA. Anaerobic Bacteria: General Concepts. Clostridium Tetani (Tetanus). Clostridium Botulinum (Botulism). Gas Gangrene and Other Clostridium-Associated Diseases. Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Anaerobic Gram-Negative Bacilli). Anaerobic Cocci. Anaerobic Gram-Positive Nonsporulating. MYCOBACTERIAL DISEASES. Mycobacterium Tuberculosis. Mycobacterium Leprae (Leprosy). Mycobacter Avium Complex. Infections due to Nontuberculous Mycobacteria. HIGHER BACTERIAL DISEASES. Nocardia Species. Agents of Actinomycosis. Section G: Mycoses . Introduction to Mycoses. Candida Species. Asperigillus Species. Agents of Mucormycosis and Related Species. Sporothrix Schenckii. Agents of Chromomycosis. Agents of Mycetoma. Cryptococcus Neoformans. Histoplasma Capsulatum. Blastomyces Dermatitidis. Coccidioides Immitis. Dermatophytosis and Other Superficial Mycoses. Paracoccidioides Brasiliensis. Miscellaneous Fungi and Prototheca. Pneumocystis Carinii. Section H: Protozoal Diseases . Introduction to Protozoal Diseases. Entamoeba Histolytica (Amebiasis). Free-Living Amebae. Plasmodium Species (Malaria). Leishmania Spec