Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.

Contents

3 Current Treatment Strategies in Non-Small Cell Lung Cancer
3.1 Early Stage in Non-Small Cell Lung Cancer 3.1.1 Radiotherapy in Early Stage Non-Small Cell Lung Cancer
Branislav Jeremi c
3.1.2 Postoperative Radiotherapy for Non-Small Cell Lung Carcinoma
Jeffrey C. Haynes and Mitchell Machtay.
3.1.3 Photodynamic Therapy
Tom G. Sutedja
3.2 Locally Advanced Non-Small Cell Lung Cancer.
3.2.1 Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer
Branislav Jeremi c and Aleksandar Dagovi c
3.2.2 Chemotherapy or Chemoradiotherapy Followed by
Surgical Resection for Non-Small Cell Lung Cancer
Nena Mirkovic and Kathy S. Albain
3.2.3 Palliative External Beam Thoracic Radiotherapy
Jason Lester and Fergus R. Macbeth
3.2.4 Intraoperative Electron Beam Radiotherapy in Lung Cancer
Javier Aristu, Leire Arbea and Felipe A. Calvo
3.2.5 Intraluminal Radiotherapy
Ron Stout, Paul A. Burt, and Philip V. Barber
4 Treatment of Small-Cell Lung Cancer
4.1 Limited Disease of Small-Cell Lung Cancer
Branislav Jeremi c
4.2 Prophylactic Cranial Irradiation in Small-Cell Lung Cancer
Cécile Le Péchoux .
5 Radiation Therapy for Recurrent Lung Cancer
Branislav Jeremi c and Michael Bamberg .
6 Radiotherapy of Lung Cancer in Elderly Patient
Branislav Jeremi c and Michael Molls .
7 Advances in Supportive and Palliative Care for Lung Cancer Patients
Michael J. Simoff and Paul A. Kvale.
8 Treatment-Related Toxicity .
8.1 Hematological Toxicity in Lung Cancer
Francesc Casas and Núria Viñolas .
Contents XIII
8.2 Radiation-Induced Lung and Heart Toxicity
Timothy D. Shafman, Xiaoli Yu, Zjelko Vujaskovic, Mitchell
Anscher, Keith Miller, Robert Prosnitz, and Lawrence B. Marks . . 351
8.3 Spinal Cord
Timothy E. Schultheiss .
8.4 Radiation Therapyy-Related Toxicity: Esophagus
Maria Werner-Wasik .
8.5 Brain
Carsten Nieder and Anca Ligia Grosu.
9 Quality of Life in Radiation Oncology of Lung Cancer
Hans Langendijk and Neil K. Aaronson.
10 Prognostic Factors in Lung Cancer
Frank B. Zimmermann.
11 Future Strategies in Lung Cancer .
11.1 Intensity-Modulated Radiation Therapy for Lung Cancer
Wilfried De Neve, Marie Chaltin, K. Vandecasteele,
and Werner De Gersem.
11.2 Stereotactic Radiotherapy and Gated Therapy
Hiroki Shirato, Rikiya Onimaru, Masaharu Fujino,
and Hiroki Onishi.
11.3 Novel Substances in the Treatment of Lung Cancer for
Radiation Oncologists
L. Chinsoo Cho and Hak Choy
11.4 PET Scanning in Staging and Evaluation of Response to Treatment of
Lung Cancer
Michael P. Mac Manus and Rodney J. Hicks
11.5 Heavy Particles in Lung Cancer
David Bush
11.6 Translational Research in Radiation Oncology of Lung Cancer
Yuhchyau Chen
12 Pitfalls in the Design, Conduct and Analysis of Randomised Clinical Trials
Richard Stephens.
13. New Directions in the Evaluation and Presentation of Clinical Research
in Lung Cancer
Elinor Thompson and Fergus Macbeth
Subject Index
List of Contributors