Contents: 1. Introduction and Overviews 2. The Skin and its Barrier Function: Implications for Wound Healing 3. The Cellular and Molecular Events of Wound Healing 4. Keratinocyte Biology and Dermal-Epidermal Interactions 5. Expression and Regulation of the Collogen Family in Skin 6. Growth Factors and Their Mode of Action 7. Role of Immunocytes, Cytokine s and Angiogenesis in Wound Healing 8. Animal Models of Wound Healing 9. Gene Therapy of Wounds 10. The Overall Clinical Approach to Wounds 11. The Chronic Wound - Failure to Heal 12. The Overall Clinical Approach to Chronic Wounds 13. Laboratory Evaluation of Non-Healing Wounds 14. Infected Wounds: Definitions and Controversies 15. Wound Dressings: Their Evolution and Use 16 Surgical Debridement of Wounds 17. Ulcers Due to Inflamatory Processes 18. Venous Ulcers and Their Management 19. Compression Treatment: Methods and Controversies 20. Case Studies in Diabetic Foot Ulcers 21. The Management of Diabetic Foot Ulcers 22. Therapeutic Options in the Management of Pressure Ulcers 23. The Use of Systemic and Topical Agents for Wound Healing 24. Surgical Management of Difficult to Heal Wounds: Vascular Approaches 25. Topical Use of Growth Factors to Enhance Healing 26. Bioengineered Skin: Manufacturing, Safety and Quality Control 27. The Clinical Experience of Bioengineered Skin Products 28. The Use of Bioengineered Skin in Burn Injury 29. Wound Bed Preparation for Optimal use of Advanced Therapeutic Products Appendix 30. Mini Atlas of Problem Wounds