This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.





AUTHOR


Kathryn Foucar

Dr. Kathy Foucar is a Distinguished Professor Emerita of Pathology at the University of New Mexico Health Sciences Center with 40+ years of practice in diagnostic hematopathology. She is the cofounder of the Hematopathology Fellowship at UNM. Dr. Foucar is the author or editor of 13 books on neoplastic and non-neoplastic hematopathology with an emphasis on blood and bone marrow, and over 120 peer-reviewed publications. She is the 2019 recipient of the Alumni Achievement Award from Ohio State University School of Medicine.
Affiliations and expertise
Distinguished Professor Emerita of Pathology, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico


2 Introduction

3 Hematopoiesis and Bone Marrow Histology

4 Bone Marrow Examination and Techniques

5 Synoptic Bone Marrow Reporting

6 Overview of Constitutional and Acquired Bone Marrow Disorders

7 Anemia

8 Overview of Anemia

9 Acquired Anemias

10 Anemias of Inflammation, Chronic Renal Disease, and Cancer

11 Iron Deficiency Anemia

12 Autoimmune Hemolytic Anemias

13 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn

14 Microangiopathic Hemolytic Anemia

15 Megaloblastic Anemia

16 Acquired Nonneoplastic Sideroblastic Anemia

17 Alcoholism-Associated Anemia

18 Anemia in the Elderly

19 Copper Deficiency-Associated Anemia

20 Acquired Red Cell Aplasia

21 Transient Erythroblastopenia of Childhood

22 Parvovirus-Induced Red Cell Aplasia

23 Paroxysmal Nocturnal Hemoglobinuria

24 Acquired Aplastic Anemia

25 Constitutional Anemias

26 Thalassemia

27 Sickle Cell Anemia

28 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency

29 Pyruvate Kinase Deficiency

30 Hereditary Spherocytosis

31 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis

32 Diamond-Blackfan Anemia

33 Fanconi Anemia

34 Congenital Dyserythropoietic Anemia

35 Congenital Sideroblastic Anemia

36 Congenital Megaloblastic Anemia

37 Erythrocytosis

38 Constitutional

39 Congenital Erythrocytosis

40 Acquired

41 Acquired Erythrocytosis

42 Benign Leukocyte Disorders in Blood and Bone Marrow

43 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow

44 Pancytopenia

45 Neutropenia

46 Neutrophilia

47 Monocytosis

48 Eosinophilia

49 Basophilia

50 Lymphocytosis

51 Lymphopenia, Constitutional and Acquired

52 Plasmacytosis of Bone Marrow

53 Hematogones in Bone Marrow

54 Lymphoid Aggregates in Bone Marrow

55 Granulomas in Bone Marrow

56 Constitutional Granulocytic Disorders

57 Constitutional Neutropenias

58 Severe Congenital Neutropenia and Cyclic Neutropenia

59 Shwachman-Diamond Syndrome

60 Chediak-Higashi Syndrome

61 Myelokathexis in WHIM Syndrome

62 Constitutional Neutrophil Anomalies

63 Pelger-Huët Anomaly

64 *MYH9*-Related Disorders

65 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

66 Megakaryocytic Disorders

67 Overview of Megakaryocytic Disorders

68 Acquired Platelet Disorders With Thrombocytopenia

69 Immune-Mediated Thrombocytopenia

70 Hemolytic-Uremic Syndrome

71 Heparin-Induced Thrombocytopenia (HIT)

72 Thrombotic Thrombocytopenic Purpura

73 Pregnancy-Associated Thrombocytopenia

74 Constitutional Platelet Disorders With Thrombocytopenia

75 Macrothrombocytopenia

76 Thrombocytopenia Absent Radius Syndrome

77 Congenital Amegakaryocytic Thrombocytopenia

78 Gray Platelet Syndrome

79 Wiskott-Aldrich Syndrome-Related Disorders

80 Congenital Thrombotic Thrombocytopenic Purpura

81 Thrombocytosis

82 Thrombocytosis

83 Infection

84 Overview of Infection

85 Hantavirus Pulmonary Syndrome

86 Human Immunodeficiency Virus

87 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)

88 Parvovirus B19 Infection

89 Bacterial Infections, Blood and Bone Marrow Features

90 Fungal Infections, Blood and Bone Marrow Features

91 Helminthic Infections

92 Malaria

93 Other Protozoan Infections

94 COVID-19 Infection

95 Miscellaneous Nonneoplastic Disorders and Conditions

96 Overview and Classification of Hemophagocytic Disorders in Bone Marrow

97 Hematologic Manifestations of Collagen Vascular Disorders

98 Hematologic Manifestations of Chronic Renal Disorders

99 Lysosomal Storage Diseases With Predominantly Histiocytic Storage

100 Homeopathic Remedies and Medications Affecting Blood and Bone Marrow

101 Other Pregnancy-Associated Hematologic Disorders

102 VEXAS Syndrome

103 Gelatinous Transformation and Other Bone Marrow Stromal Disorders

104 Crystals in Bone Marrow

105 Bone Abnormalities in Bone Marrow Specimens

106 Myeloid Neoplasms

107 Overview and Classification of Myeloid Neoplasms

108 Specialized Testing in Myeloid Neoplasms

109 Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia

110 Myeloproliferative Neoplasms

111 Overview of Myeloproliferative Neoplasms

112 Chronic Myeloid Leukemia, *BCR-ABL1* Positive

113 Chronic Neutrophilic Leukemia

114 Polycythemia Vera

115 Primary Myelofibrosis

116 Essential Thrombocythemia

117 Chronic Eosinophilic Leukemia, Not Otherwise Specified

118 Myeloproliferative Neoplasm, Unclassifiable

119 Mastocytosis

120 Systemic Mastocytosis

121 Mast Cell Leukemia

122 Myeloid and Lymphoid Neoplasms With Eosinophilia and Gene Rearrangements

123 Myeloid and Lymphoid Neoplasms With *PDGFRA* Rearrangement

124 Myeloid and Lymphoid Neoplasms With *PDGRFB* Rearrangement

125 Myeloid and Lymphoid Neoplasms With *FGFR1* Rearrangement

126 Myeloid and Lymphoid Neoplasms With *FLT3* Rearrangement

127 Myelodysplastic/Myeloproliferative Neoplasms

128 Overview of Myelodysplastic/Myeloproliferative Neoplasms

129 Chronic Myelomonocytic Leukemia

130 Atypical Chronic Myeloid Leukemia, *BCR-ABL1* Negative (aCML)

131 Juvenile Myelomonocytic Leukemia

132 Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis

133 Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable

134 Myelodysplastic Syndromes

135 Overview and Classification of Myelodysplastic Syndromes

136 Clonal Hematopoiesis of Indeterminant Potential (CHIP)

137 Myelodysplastic Syndrome With Single Lineage Dysplasia

138 Myelodysplastic Syndromes With Ring Sideroblasts

139 Myelodysplastic Syndrome With Multilineage Dysplasia

140 Myelodysplastic Syndromes With Excess Blasts

141 Myelodysplastic Syndrome With Isolated del(5q)

142 Myelodysplastic Syndrome, Unclassifiable

143 Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)

144 Acute Myeloid Leukemia

145 Overview of Acute Myeloid Leukemia

146 Familial AML/MDS (Germline Predisposition)

147 Acute Myeloid Leukemia With t(8;21)(q22;q22.1), *RUNX1-RUNX1T1*

148 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), *CBFB-MYH11*

149 Acute Promyelocytic Leukemia With *PML-RARA*

150 Acute Promyelocytic Leukemia With Variant *RARA* Rearrangement

151 Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3), *KMT2A-MLLT3*

152 Subtypes of Acute Myeloid Leukemia: t(6;9), inv(3), t(1;22), t(9;22), Mutated *NPM1,* Biallelic Mutated *CEBPA,* Mutated *RUNX1*

153 Acute Myeloid Leukemia With Myelodysplasia-Related Changes

154 Therapy-Related Myeloid Neoplasms

155 Acute Myeloid Leukemia With Minimal Differentiation (AML, NOS)

156 Acute Myeloid Leukemia Without Maturation (AML, NOS)

157 Acute Myeloid Leukemia With Maturation (AML, NOS)

158 Acute Myelomonocytic Leukemia (AML, NOS)

159 Acute Monoblastic and Monocytic Leukemia (AML, NOS)

160 Pure Erythroid Leukemia (AML, NOS)

161 Acute Megakaryoblastic Leukemia, Not Otherwise Specified

162 Acute Basophilic Leukemia (AML, NOS)

163 Acute Panmyelosis With Myelofibrosis (AML, NOS)

164 Myeloid Proliferations Related to Down Syndrome

165 Measurable Residual Disease Testing Strategies in AML

166 Blastic Plasmacytoid Dendritic Cell Neoplasm

167 Blastic Plasmacytoid Dendritic Cell Neoplasm

168 Acute Leukemias of Ambiguous Lineage

169 Acute Undifferentiated Leukemia

170 Mixed Phenotype Acute Leukemia

171 Lymphoid Neoplasms

172 Overview of Lymphoid Neoplasms

173 Specialized Testing in Lymphoid Neoplasms

174 B-Precursor Neoplasms

175 B-Lymphoblastic Leukemia

176 Novel Genetic Subtypes of B-Lymphoblastic Leukemia

177 BCR-ABL1-Like ALL

178 Measurable Residual Disease Testing Strategies in ALL

179 T-Precursor Neoplasms

180 T-Lymphoblastic Leukemia/Lymphoma

181 Early T-Cell Precursor Acute Lymphoblastic Leukemia

182 Mature B-Cell Neoplasms

183 Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Lymphomas

184 Monoclonal B-Cell Lymphocytosis

185 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

186 B-Cell Prolymphocytic Leukemia

187 Splenic Marginal Zone Lymphoma

188 Hairy Cell Leukemia

189 Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant

190 Lymphoplasmacytic Lymphoma

191 Gamma Heavy Chain Disease

192 Monoclonal Gammopathy of Undetermined Significance

193 Plasma Cell Myeloma

194 Burkitt Leukemia/Lymphoma

195 Mantle Cell Lymphoma in Blood and Bone Marrow

196 Follicular Lymphoma in Blood and Bone Marrow

197 Marginal Zone Lymphoma in Blood and Bone Marrow

198 Large B-Cell Lymphomas in Blood and Bone Marrow

199 Mature T-/NK-Cell Neoplasms

200 Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow

201 T-Cell Prolymphocytic Leukemia

202 T-Cell Large Granular Lymphocytic Leukemia

203 Chronic Lymphoproliferative Disorder of NK Cells

204 Aggressive NK-Cell Leukemia

205 Adult T-Cell Leukemia

206 Mycosis Fungoides/Sézary Syndrome

207 Anaplastic Large Cell Lymphoma in Blood and Bone Marrow

208 Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

209 Hodgkin Lymphoma in Bone Marrow

210 Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte-Predominant Subtypes

211 Other Neoplasms Involving Bone Marrow

212 Langerhans Cell Histiocytosis in Bone Marrow

213 Posttransplant Lymphoproliferative Disorders in Bone Marrow

214 Metastatic Carcinoma and Sarcoma

215 CAP Protocol

216 Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms