For more than 45 years, Avery & MacDonald's Neonatology has been the premier text on the pathophysiology and management of both preterm and full-term neonates, trusted by neonatologists, neonatology fellows, pediatricians, neonatal nurse practitioners, and ob/gyn practitioners worldwide. Continuing the tradition of excellence established by Drs. Gordon B. Avery and Mhairi G. MacDonald, this fully revised eighth edition features three new lead editors, numerous new chapters, reorganized and updated content, and an increased focus on global neonatology.

Continues to provide comprehensive, accessible coverage of how diseases occur and how their pathophysiology drives management.

Covers the wide breadth of care of the newborn patient, including maternal factors, stabilization of the newborn, common newborn issues, pharmacology, and care after discharge.

Contains a wealth of integrated, practical advice on treating neonates worldwide, including global viewpoints on providing care without the latest technology and under various international guidelines.

Includes new chapters on recent advances in neonatology, including fetal surgery, global health, molecular genetics, immunology and inflammation, thermoregulation, palliative care, imaging, and genetic abnormalities.

Reflects new research on the impact of maternal drug use on the newborn, nutrition, pulmonary disorders, discharge planning, and care of the preterm and small for gestational age infant.

Features timely content on advances in ethical concepts about neonatal care at the limits of viability, family integrated care, early life determinants of life course disease, the impact of the COVID-19 pandemic, and much more.

Enrich Your eBook Reading Experience

Read directly on your preferred device(s), such as computer, tablet, or smartphone.

Easily convert to audiobook, powering your content with natural language text-to-speech.


Contents
Contributors vi
Foreword xv
Preface xvi
Preface to the First Edition xvii
PART 1: GENERAL CONSIDERATIONS
Newborn Survival in a Global Context 1
Joy E. Lawn, Samantha Sadoo, Cally J. Tann,
and Nahya Salim Masoud
The Scope and Organization of Perinatal Services:
Global Comparisons and Challenges 16
Judy L. Aschner, Stephen W. Patrick, Ann R. Stark,
and Shoo K. Lee
Newborn Intensive Care Unit Design: Scientific and
Practical Considerations 29
Robert D. White, Judith A. Smith, and Gilbert I. Martin
Data Collection Systems for Service Evaluation and
Research 34
Neena Modi
Quality Assessment and Improvement 40
Scott A. Lorch
Inter -Hospital T ransport 50
Hilary E. A. Whyte and Andrew Berry
Perinatal Medical Ethics, Decision-Making,
and Legal Principles 69
Dominic J. C. Wilkinson, Gregory P. Moore,
and Amir M. Zayegh
Care of the Family, Palliative Care, Brain Death,
and Organ Donation 80
Krishelle L. Marc-Aurele
Discharge Planning, Follow-Up Care, and Outcome
Evaluation 90
Angela Huertas-Ceballos and Katie Mckinnon
PART 2: THE FETAL PATIENT
10 Prenatal Diagnosis and Management in the Molecular
Age Indications, Procedures, and Laboratory
T echniques 109
Mark I. Evans, Dana Brabbing-Goldstein, Shara M. Evans,
and Yuval Yaron
11 Multiple Gestation 137
Scott W. White
12 Placental Physiology, the In Utero Environment, and
Antenatal Determinants of Disease 148
Ian P. Crocker
13 The Impact of Maternal Illness and Therapy
on the Fetus and Neonate 155
Adalina Sacco, Sarah Guillon, and Anna L. David
14 The Impact of Prenatal Exposure to Nonnarcotic
Drugs: Maternal, Fetal, Neonatal, and Long-T erm
Outcomes 165
Enrique M. Ostrea Jr, Josef M. Cortez, Maria Esterlita T.
Villanueva-Uy, and Jonathan M. Gamiao
PART 3: CARE AROUND BIRTH
15 T ransition and Stabilization 187
Ruben E. Alvaro
16 Delivery Room Management 201
Colm P. F. O'Donnell and Alan M. Groves
17 Physical Assessment and Classification 215
Leigh E. Dyet and Rose Crowley
18 Care of the Normal Newborn 238
Karen L. Kamholz and Jessica M. McGovern
PART 4: THE NEWBORN INFANT
19 Fluid and Electrolyte Management 251
Sabita Uthaya
20 Nutrition 258
Sara E. Ramel and Michael K. Georgieff
21 Radiology 278
Jeremy B. Jones
22 Health Care Associated Infections 299
Joseph B. Cantey and Rebekah C. Gardea
23 Pharmacology 307
Mark A. Turner
24 Anesthesia and Analgesia 316
Sally H. Vitali
25 The Preterm Infant 326
Jayashree Ramasethu
26 The Small-for-Gestational Age Infant and IUGR 342
Bianca Carducci, Susan C. Campisi, Samia Aleem, and
Zulfiqar A. Bhutta
27 Control of Breathing: Maturation and Associated
Clinical Disorders 352
Nicole R. Dobson, Mark W. Thompson, and Carl E. Hunt
28 Acute Pulmonary Disorders 364
Jeffrey A. Whitsett, Amy T. Nathan, Shawn K. Ahlfeld,
Gloria S. Pryhuber, and Paul S. Kingma29 Bronchopulmonary Dysplasia 386
Robin H. Steinhorn and Jonathan M. Davis
30 Surgical Management of the Airway and Lungs 400
Alison Maresh, Annie Harrington, Peter S. Midulla,
and Vikash K. Modi
31 Hemodynamics 419
Patrick J. McNamara, Dany Weisz, Amish Jain,
and Regan E. Giesinger
32 Structural Cardiac Disease and Cardiomyopathies 459
David Blundell, Caroline Jones, and David S. Crossland
33 Postoperative Management and Care of the Cardiac
Surgical Patient 491
John M. Costello, Sinai C. Zyblewski, Jason R. Buckley, and
Luke W. Schroeder
34 Disorders of Cardiac Rhythm 523
Luciana Marcondes and Jonathan R. Skinner
35 Development of Structure and Function of the
Gastrointestinal T ract 536
Diomel M. de la Cruz and Josef Neu
36 Disorders of the Gastrointestinal T ract 546
Janice A. Taylor and Josef Neu
37 Hepatobiliary Disorders 564
Björn Fischler, Afrodite Psaros Einberg, and Maria
Magnusson
38 Renal Disease 575
Suhas M. Nafday, Craig B. Woda, Jeffrey M. Saland, Joseph
T. Flynn, David Askenazi, and Luc P. Brion
39 Structural Abnormalities of the Genitourinary
T ract 623
Irene M. McAleer and Kai-wen Chuang
40 Endocrine Disorders 658
Penny M. Feldman and Mary M. Lee
41 Homeostasis of Carbohydrate and Other Fuels 678
J. M. Hawdon and James P. Boardman
42 Red Blood Cells and Their Disorders 695
Subarna Chakravorty and Irene Roberts
43 White Blood Cells and Their Disorders 708
Suneetha Desiraju and George J. Dover
44 Platelets and Disorders of Coagulation 714
Martha Sola-Visner and Matthew A. Saxonhouse
45 Neonatal Hyperbilirubinemia 731
Vinod K. Bhutani and Ronald J. Wong
46 Congenital Infections 748
Swetha G. Pinninti and David W. Kimberlin
47 Evaluation and Management of Infection in the
Newborn 767
Miren B. Dhudasia, Dustin D. Flannery,
and Karen M. Puopolo
48 Immunology 779
Kristin Scheible
49 Brain Injury at T erm 792
Andrew Whitelaw and Marianne Thoresen
50 Brain Development and Injury in Preterm Infants 804
David Edwards, Serena J. Counsell, and Pierre Gressens
51 Neonatal Seizures 819
Amanda G. Sandoval Karamian and Courtney J. Wusthoff
52 Neuromuscular Disorders 828
Eugenio Mercuri and Marika Pane
53 Neurosurgery 835
Kristian Aquilina
54 Neonatal Abstinence Syndrome 853
Hendrée E. Jones, Gerri R. Baer, and Jonathan M. Davis
55 Inherited Metabolic Disorders 861
Barbara K. Burton
56 Genetics and Genomics 872
Margo Sheck Breilyn and Bruce D. Gelb
57 Congenital Anomalies and Genetic Disease 877
Tara L. Wenger and Elizabeth J. Bhoj
58 Eye Disorders 891
Stacy L. Pineles and Sherwin J. Isenberg
59 Oncology 905
Lauren H. Boal and Howard J. Weinstein
60 Orthopedics 917
Deborah M. Eastwood
61 Dermatology 930
Kaiane A. Habeshian, Ha-young Choi,
and Robert A. Silverman
Index 959