This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.

These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Thymus

Pearse, Gail, B.V.M. & S., D.A.C.V.P.

Pages 1-35
Spleen

Papenfuss, Tracey L. (et al.)

Pages 37-57
Lymph Node

Elmore, Susan A., M.S., D.V.M. (et al.)

Pages 59-79
Mucosa-Associated Lymphoid Tissues

Kuper, Christine Frieke (et al.)

Pages 81-121
Immunopathology of the Nervous System

Remick, Amera K., DVM, MS, DACVP, DABT (et al.)

Pages 123-219
Immunopathology of the Urinary System

Picut, Catherine A.

Pages 221-327
Immunopathology of the Hepatobiliary System

Brown, Danielle L.

Pages 329-417
Immunopathology of the Respiratory System

Greeley, Melanie A.

Pages 419-453
Immunopathology of the Cardiovascular System

Boyle, Molly H.

Pages 455-477
Immunopathology of the Male Reproductive Tract

Picut, Catherine A., VMD, JD, DACVP, DABT (et al.)

Pages 479-539
Immunopathology of the Female Reproductive Tract and Mammary Gland

Picut, Catherine A., VMD, JD, DACVP, DABT (et al.)

Pages 541-614
Immunopathology of the Musculoskeletal System

Bolon, Brad, DVM,MS,PhD,DACVP,DABT,FATS,FIATP (et al.)

Pages 615-648
Immunopathology of the Endocrine System

Rosol, Thomas J. (et al.)

Pages 649-694
Ocular Immunopathology

Ramos, Meg Ferrell (et al.)

Pages 695-762
Immunopathology of Drug and Toxin-Related Skin Reactions