Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients.

Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.

Key Features
Provides an overview of all congenital and acquired bone marrow failure syndromes
Focuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromes
Features the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services

Table of Contents

List of Contributors
Introduction
Chapter 1: Epidemiology of Acquired Bone Marrow Failure
Abstract
Introduction
Incidence of AA in different geographical regions and race
Age and gender related demographics of AA
Posthepatitis AA and AA occurring after viral infections
AA and association with toxins/drugs
AA and association with HLA genes
AA and autoimmune disorders
AA during pregnancy
AA postvaccination
Problems with epidemiological studies in AA and future strategies
Chapter 2: Pathophysiology of Acquired Bone Marrow Failure
Abstract
Introduction: Evidence and inferences from the clinic
Pathophysiology
Treatments for AA
Conclusions
Chapter 3: Diagnosis of Acquired Aplastic Anemia
Abstract
Introduction
Approach to diagnosis of aplastic anemia
Diagnosis confirmation
Characterization of aplastic anemia
Future challenges in the diagnostics of AA
Acknowledgment
Chapter 4: Acquired Overlap Bone Marrow Failure Disorders
Abstract
Introduction
Hypoplastic MDS
Single lineage cytopenias (pure red cell aplasia or immune thrombocytopenia)
T cell large granular lymphocytes
Paroxysmal nocturnal hemoglobinuria
Congenital marrow failure undiagnosed
Conclusions
Chapter 5: Supportive Care in Aplastic Anemia
Abstract
Introduction
Prevention of infections by general medical management of aplastic anemia patients
Prevention of infections by antibiotic/antimycotic/antiviral prophylaxis
Hematopoietic growth factors as prophylaxis of infections or in combination with immunosuppressio