Describes recent advances in scientific, medical and technical understanding of the aging skin
Covers all aspects, from basic science to diseases, techniques, toxicology, and psychosocial issues
Explores global perspectives, including perception, needs and responses to skin aging
Brings the reader up to date with many completely new chapters

This comprehensive book presents the latest information on all aspects of the aging skin, including a broad spectrum of the relevant basic science, malignant and non-malignant age-associated diseases and conditions, techniques and methods, toxicological and safety considerations in the elderly, psychological and social issues, ethnicity and gender differences and marketing to the aged. Since the first edition the book has been extensively updated and revised, with the inclusion of many additional chapters that describe the most recent advances in scientific, medical and technical understanding of the aging phenomenon. There is, for example, extended coverage of physiology, description of novel bioengineering methods and tools, detailed consideration of developments in genomics research, and information on new ingredients and products. Textbook of Aging Skin is written by global experts and thought leaders and is intended to serve as the single and complete reference on the subject. It will be of value for dermatologists, gerontologists, toxicologists, biologists and a range of other professionals.

Histology of Microvascular Aging of Human Skin
Helmbold, Peter
Pages 3-10
Basophilic (Actinic) Degeneration of the Dermis: An Easy Histological Scoring Approach in Dermal Photoaging
Helmbold, Peter
Pages 11-14
Degenerative Changes in Aging Skin
Farage, Miranda A. (et al.)
Pages 15-30
An Overview of the Histology of Aging Skin in Laboratory Models
Bhattacharyya, Tapan K.
Pages 31-41
Major Changes in Skin Function in the Elderly and Their Contributions to Common Clinical Challenges
Millsop, Jillian Wong (et al.)
Pages 43-53
Skin Aging: A Brief Summary of Characteristic Changes
Wiegand, Cornelia (et al.)
Pages 55-65
The Stratum Corneum and Aging
Rawlings, Anthony V.
Pages 67-90
The Extracellular Matrix Protein 1 (ECM1) in Molecular-Based Skin Biology
Oyama, Noritaka (et al.)
Pages 91-110
Pathomechanisms of Endogenously Aged Skin
Makrantonaki, Evgenia (et al.)
Pages 111-120
Pathomechanisms of Photoaged Skin
Krutmann, Jean
Pages 121-129
Proteoglycans in Skin Aging
Maquart, François-Xavier (et al.)
Pages 131-147
Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases, Serine Proteinases, and Heparanase in Skin Aging Process
Amano, Satoshi
Pages 149-160
Buffering Capacity Considerations in the Elderly
Levin, Jacquelyn (et al.)
Pages 161-172
Considerations for Thermal Injury: The Elderly as a Sensitive Population
Bjerke, Donald L.
Pages 173-190
Aging of Epidermal Stem Cells
Charruyer, Alexandra (et al.)
Pages 191-204
Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss
Park, Byung-Soon (et al.)
Pages 205-224
Peroxisome Proliferator-Activated Receptors: Role in Skin Health and Appearance of Photoaged Skin
Hawkins, Stacy S. (et al.)
Pages 225-238
Hyaluronan and the Process of Aging in Skin
Rivers, Diana Alyce (et al.)
Pages 239-254
Changes in Nail in the Aged
Rubeiz, Nelly (et al.)
Pages 255-263
Changes in the Composition of the Cornified Envelope During Skin Aging: A Calcium Centric Point of View
Streubel, Maria Karolin (et al.)
Pages 265-284
arNOX: A New Source of Aging
Morré, Dorothy M. (et al.)
Pages 285-294
arNOX: New Mechanisms of Skin Aging and Lipoprotein Oxidation
Morré, D. James (et al.)
Pages 295-307
Age-Related Changes in Skin Mechanical Properties
Krueger, Nils (et al.)
Pages 309-317
Age-Induced Hair Graying and Oxidative Stress
Seiberg, Miri
Pages 319-330
Appearance and Internal Aging
Yamada, Hidekazu
Pages 331-340
Age-Related Morphometric Changes of Inner Structures of the Skin Assessed by In Vivo Reflectance Confocal Microscopy
Tsuchida, Katsuhiko (et al.)
Pages 341-349
Facial Skin Rheology
Piérard, Gérald E. (et al.)
Pages 351-362
Pathology of Aging Skin
Jia, Qunshan (et al.)
Pages 363-385
Biology of Stratum Corneum: Tape Stripping and Protein Quantification
Zhu, Hanjiang (et al.)
Pages 387-396
Corneocyte Size and Cell Renewal: Effects of Aging and Sex Hormones
Darlenski, Razvigor (et al.)
Pages 397-404
Stratum Corneum Cell Layers
Tagami, Hachiro
Pages 405-413
Aging and Melanocytes Stimulating Cytokine Expressed by Keratinocyte and Fibroblast
Okazaki, Mutsumi
Pages 415-422
Cyanoacrylate Skin Surface Strippings
Piérard-Franchimont, Claudine (et al.)
Pages 423-434
Vaginal Secretions with Age
Summers, Paul R.
Pages 435-441
Unique Skin Immunology of the Lower Female Genital Tract with Age
Summers, Paul R.
Pages 443-448
Aging Genital Skin and Hormone Replacement Therapy Benefits
Ledger, William J.
Pages 449-456
Platinum and Palladium Nanoparticles Regulate the Redox Balance and Protect Against Age-Related Skin Changes in Mice
Shibuya, Shuichi (et al.)
Pages 457-467
Skin Aging: An Immunohistochemical Evaluation
El-Domyati, Moetaz (et al.)
Pages 469-484
Advanced Age Pruritus
Metkowski, Afton (et al.)
Pages 485-502
Physiological Variations During Aging
Piérard, Gérald E. (et al.)
Pages 503-514
Neurotrophins and Skin Aging
Adly, Mohamed A. (et al.)
Pages 515-527
Cluster of Differentiation 1d (CD1d) and Skin Aging
Adly, Mohamed A. (et al.)
Pages 529-535
The Genetics of Skin Aging
Gunn, David A.
Pages 537-550
Skin Aging and Health
Gunn, David A. (et al.)
Pages 551-562
Influence of Exogenous Factors on Skin Aging
Ahuja, Avani (et al.)
Pages 563-577
Impact of Dietary Supplements on Skin Aging
Raj, Utkrishta L. (et al.)
Pages 579-591
Alterations of Energy Metabolism in Cutaneous Aging
Blatt, Thomas (et al.)
Pages 595-616
Cellular Energy Metabolism and Oxidative Stress
Cheng, Shujiang (Suzie) (et al.)
Pages 617-627
DNA Damage and Repair in Skin Aging
Yarosh, Daniel B.
Pages 629-640
Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis
Amano, Satoshi
Pages 641-649
Cutaneous Oxidative Stress and Aging
Polefka, Thomas G. (et al.)
Pages 651-676
Cutaneous Responses to Tropospheric Ozone Exposure
Valacchi, Giuseppe
Pages 679-693
Infrared A-Induced Skin Aging
Schroeder, Peter (et al.)
Pages 695-700
Climate Change and Its Dermatologic Impact on Aging Skin
Hui, Young (et al.)
Pages 701-708
Skin Photodamage Prevention: State of the Art and New Prospects
Ainbinder, Denize (et al.)
Pages 709-722
Environmental and Genetic Factors in Facial Aging in Twins
Rowe, David J. (et al.)
Pages 723-731
Tobacco Smoke and Skin Aging
Morita, Akimichi
Pages 733-738
Sebum Production
Piérard-Franchimont, Claudine (et al.)
Pages 739-751
Perimenopausal Aging and Oral Hormone Replacement Therapy
Hermanns-Lê, Trinh (et al.)
Pages 753-762
Biological Effects of Estrogen on Skin
Phuong, Christina (et al.)
Pages 763-774
DNA Biomarkers in Aging Skin
Norman, Kimberly G. (et al.)
Pages 775-781
Aging and Intrinsic Aging: Pathogenesis and Manifestations
Assaf, Hanan (et al.)
Pages 783-794
Infrared Radiation: Mechanisms, Implications, and Protection
Nia, Kasra Soltani (et al.)
Pages 795-802
Nonneoplastic Disorders of the Aging Skin
Farage, Miranda A. (et al.)
Pages 805-826
Neoplastic Skin Lesions in the Elderly Patient
Farage, Miranda A. (et al.)
Pages 827-855
Cutaneous Effects and Sensitive Skin with Incontinence in the Aged
Farage, Miranda A. (et al.)
Pages 857-868
Aging Skin as a Diagnostic Tool for Internal Diseases: A Chance for Dermatology
Nikolakis, Georgios (et al.)
Pages 869-885
Carcinogenesis: UV Radiation
Brash, Douglas E. (et al.)
Pages 887-902
Melanoma and Skin Aging
Torres, Salina M. (et al.)
Pages 903-912
Aging-Associated Nonmelanoma Skin Cancer: A Role for the Dermis
Lewis, Davina A. (et al.)
Pages 913-930
Nonsurgical Modalities of Treatment for Primary Cutaneous Cancers
Abadi, Rami (et al.)
Pages 931-941
Sunlight Exposure and Skin Thickness Measurements as a Function of Age: Risk Factors for Melanoma
Elmahdy, Akram (et al.)
Pages 943-951
Influence of Race, Gender, Age, and Diabetes on Blood Flow
Petrofsky, Jerrold Scott
Pages 953-969
Atopic Dermatitis in the Aged
Katsarou, Alexandra (et al.)
Pages 971-989
Dry Skin in Diabetes Mellitus and in Experimental Models of Diabetes
Sakai, Shingo (et al.)
Pages 991-1002
Impaired Wound Repair and Delayed Angiogenesis
Schrementi, Megan E. (et al.)
Pages 1003-1015
Hyperpigmentation in Aging Skin
Hakozaki, Tomohiro (et al.)
Pages 1017-1026
Pigmentation in Ethnic Groups
Maibach, Howard I. (et al.)
Pages 1027-1038
The New Face of Pigmentation and Aging
Nip, John (et al.)
Pages 1039-1054
Facial Wrinkling: The Marquee Clinical Sign of Aging Skin
Hillebrand, Greg
Pages 1055-1064
Psoriasis and Aging
Yamauchi, Paul S.
Pages 1065-1070
Skin Aging and Cellulite in Women
Lorencini, Márcio (et al.)
Pages 1071-1079
Skin Itch in the Elderly
Petrofsky, Jerrold Scott
Pages 1081-1090
Control of Skin Blood Flow
Petrofsky, Jerrold Scott
Pages 1091-1104
Bioengineering Methods and Skin Aging
Giusti, Francesca (et al.)
Pages 1107-1116
Hydration of the Skin Surface
Tagami, Hachiro
Pages 1117-1126
Corneocyte Analysis
Hirao, Tetsuji
Pages 1127-1140
The Structural and Functional Development of Skin During the First Year of Life: Investigations Using Noninvasive Methods
Stamatas, Georgios N.
Pages 1141-1153
Structure of Stratum Corneum Lipid Studied by Electron Paramagnetic Resonance
Nakagawa, Kouichi
Pages 1155-1170
Molecular Concentration Profiling in the Skin Using Confocal Raman Spectroscopy
Crowther, Jonathan M. (et al.)
Pages 1171-1187
The Measurement and Perception of Uneven Coloration in Aging Skin
Matts, Paul J.
Pages 1189-1196
Transepidermal Water Loss in Young and Aged Healthy Humans
Kottner, Jan (et al.)
Pages 1197-1202
Reconstructed Skin to Create In Vitro Flexible Models of Skin Aging: New Results and Prospects
Asselineau, Daniel (et al.)
Pages 1203-1228
In Vitro Method to Visualize UV-Induced Reactive Oxygen Species in a Skin Equivalent Model
Hakozaki, Tomohiro
Pages 1229-1238
Aging and Senescence of Skin Cells in Culture
Rattan, Suresh I. S.
Pages 1239-1246
Glycation and Skin Aging
Pageon, Herve (et al.)
Pages 1247-1270
Assessing Quality of Life in Older Adult Patients with Skin Disorders
Farage, Miranda A. (et al.)
Pages 1271-1288
Skin Aging: A Generalization of the Microinflammatory Hypothesis
Giacomoni, Paolo U. (et al.)
Pages 1289-1298
The Potential of Probiotics and Prebiotics for Skin Health
Ouwehand, A. C. (et al.)
Pages 1299-1313
Probiotics in Aging Skin
Cinque, Benedetta (et al.)
Pages 1315-1327
Animal Models
Krishnasamy, Shalini (et al.)
Pages 1329-1335
New Insights in Photoaging Process Revealed by In Vitro Reconstructed Skin Models
Marionnet, Claire (et al.)
Pages 1337-1360
Skinomics: A New Toolbox to Understand Skin Aging
Younis, Sidra (et al.)
Pages 1361-1379
Reflectance Confocal Microscopy and Aging
Raphael, Anthony P. (et al.)
Pages 1381-1397
Susceptibility to Irritation in the Elderly
Farage, Miranda A. (et al.)
Pages 1401-1416
The Vaginal Microbiota in Menopause
Farage, Miranda A. (et al.)
Pages 1417-1431
Irritant Contact Dermatitis
Lukács, Judit (et al.)
Pages 1433-1442
Safety Evaluation in the Elderly via Dermatological Exposure
Bramante, Mario
Pages 1443-1455
Dermal Safety Evaluation: Use of Disposable Diaper Products in the Elderly
Marsman, Daniel S. (et al.)
Pages 1457-1471
Aging Skin Microbiology
Charbonneau, Duane L. (et al.)
Pages 1473-1488
Percutaneous Penetration of Chemicals and Aging Skin
Hughes, Michael F.
Pages 1489-1502
Application of In Vitro Methods in Preclinical Safety Assessment of Skin Care Products
Costin, Gertrude-Emilia (et al.)
Pages 1503-1521
Genetic Basis of Healthy Skin Aging
Chang, Anne Lynn S.
Pages 1525-1528
Genodermatoses with Premature Aging/Syndromes
Chedraoui, Adele (et al.)
Pages 1529-1547
Resetting Skin Genome Back to Health Naturally with GHK
Pickart, Loren (et al.)
Pages 1549-1566
Assessing Quality of Ordinal Scales Depicting Skin Aging Severity
Valet, Fabien (et al.)
Pages 1569-1577
The Baumann Skin Typing System
Baumann, Leslie S.
Pages 1579-1597
Preventive Skin Care During Skin Aging
Lichterfeld, Andrea (et al.)
Pages 1601-1612
Discovering the Link Between Nutrition and Skin Aging
Liakou, Aikaterini I. (et al.)
Pages 1613-1618
Aging Skin: Nourishing from the Inside Out Effects of Good Versus Poor Nitrogen Intake on Skin Health and Healing
Corsetti, Giovanni (et al.)
Pages 1619-1629
Aging Skin: Nourishing from Out-In Lessons from Wound Healing
Corsetti, Giovanni (et al.)
Pages 1631-1641
Psychological and Social Implications of Aging Skin: Normal Aging and the Effects of Cutaneous Disease
Farage, Miranda A. (et al.)
Pages 1645-1656
Aging Skin: Some Psychosomatic Aspects
Gupta, Madhulika A.
Pages 1657-1674
Advanced Glycation End Products (AGEs): Emerging Mediators of Skin Aging
Gkogkolou, Paraskevi (et al.)
Pages 1675-1686
Facial Skin Attributes and Age Perception
Nkengne, Alex (et al.)
Pages 1689-1700
The Neuroscience of Age Perception
Yarosh, Daniel B.
Pages 1701-1706
Determinants in the Rate of Skin Aging: Ethnicity, Gender, and Lifestyle Influences
Farage, Miranda A. (et al.)
Pages 1709-1727
Gender Differences in Skin
Phuong, Christina (et al.)
Pages 1729-1755
Aging in Asian Skin
Ling, Low Chai
Pages 1757-1764
Perceptions of Sensitive Skin with Age
Farage, Miranda A.
Pages 1767-1791
Effects of Aging on Skin Reactivity
Robinson, Michael K.
Pages 1793-1800
Skin Reactivity of the Human Face: Functional Map and Age Related Differences
Cadavona, John Jay P. (et al.)
Pages 1801-1813
Aging and Antiaging Strategies
Balistreri, Carmela Rita (et al.)
Pages 1817-1827
Cosmetics and Aging Skin
Bronaugh, Robert L. (et al.)
Pages 1829-1837
Cosmetic Antiaging Ingredients
Bissett, Donald L. (et al.)
Pages 1839-1851
Topical Growth Factors for Skin Rejuvenation
Dreher, Frank
Pages 1853-1864
Topical Peptides and Proteins for Aging Skin
Gorouhi, Farzam (et al.)
Pages 1865-1896
Long-Term Estrogen Effects on Sun-Exposed Human Skin
Yoon, Hyun Sun (et al.)
Pages 1897-1907
Solutions and Products for Managing Female Urinary Incontinence
Karapasha, Nancy
Pages 1909-1915
Therapeutic Alternatives for the Treatment of Epidermal Aging
Brohem, Carla Abdo (et al.)
Pages 1917-1927
Influence of Aging on Sensorial Perception of Skin Care Products
Mambro, Valéria Maria (et al.)
Pages 1929-1936
The Role of Neuropeptides in Skin Wound Healing
Choi, Yun-Hee (et al.)
Pages 1937-1948
Wound Healing as We Age
Rahal, Jihane Abou (et al.)
Pages 1949-1958
Antiaging Effects of Algae-Derived Mycosporine-Like Amino Acids (MAAs) on Skin
Lee, Jeong Hun (et al.)
Pages 1959-1966
Innovative Nutraceutical Approaches to Counteract the Signs of Aging
Genovese, Licia (et al.)
Pages 1967-1991
Neck Rejuvenation with Fractional CO
Akkaya, A. Deniz (et al.)
Pages 1993-2001
Changes in Vulvar Physiology and Skin Disorders with Age and Benefits of Feminine Wipes in Postmenopausal Women
Farage, Miranda A. (et al.)
Pages 2003-2013
A New Paradigm for the Aging Face
Lam, Samuel M.
Pages 2017-2025
Cosmetic Surgery in the Elderly
Scarborough, Richard (et al.)
Pages 2027-2058
Facial Rejuvenation: A Chronology of Procedures
Donath, Alexander S.
Pages 2059-2071
Elderly Face No Added Risk from Cosmetic Surgery
Winocour, Julian (et al.)
Pages 2073-2082
Punctural Face Rejuvenation
Roganin, Igor
Pages 2083-2093
Bridging Science and Beauty
Kim, Christine C. (et al.)
Pages 2095-2098
Botulinum Toxin Type A and Laser Resurfacing Provide Adjunctive Benefit to Skin Aging
Yamauchi, Paul S. (et al.)
Pages 2099-2103
Update on Asian Eyelid Anatomy and Periocular Aging Change
Saonanon, Preamjit (et al.)
Pages 2105-2117
Unified Mind/Body for a Healthy Aging Skin
Farage, Miranda A. (et al.)
Pages 2121-2129
Brain-Skin Connection: Impact of Psychological Stress on Skin
Chen, Ying (et al.)
Pages 2131-2152
Place Your Bets, the Die Is Cast: The Skin at the Retiring Age Today and Tomorrow
Piérard-Franchimont, Claudine (et al.)
Pages 2153-2159
Sleep and Aging Skin
Guan, Linna (et al.)
Pages 2161-2173
Marketing and Product Design of Antiaging Skin Care Products
Dawes, Nancy C.
Pages 2177-2187
Key Trends Driving Antiaging Skin Care in 2009 and Beyond
Gasco-Buisson, Mary Carmen
Pages 2189-2200