Features

Summarizes what is known of the structure and life history of adenoviruses
Describes the innate and adaptive immune responses to adenoviruses including ways to minimize any adverse reactions
Explores the various ways in which adenoviruses are currently used in gene and cell therapy
Examines the anticipated role of adenoviruses in vaccination and the treatment of various cancers
Provides guidance regarding anticipated regulatory requirements
Summary

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.

Table of Contents

Adenovirus Biology and Development as a Gene Delivery Vector.
Leslie A. Nash and Robin J. Parks

Innate and adaptive immune responses to adenovirus.
Svetlana Atasheva and Dmitry M. Shayakhmetov.

Helper-dependent adenoviral vectors for cell and gene therapy.
Nicola Brunetti-Pierri and Philip Ng

Chemical and combined genetic and chemical modifications of adenovirus vector capsids to overcome barriers for in vivo vector delivery.
Florian Kreppel.

Design and applications of adenovirus-based hybrid vectors.
Anja Ehrhardt and Wenli Zhang

Adenovirus vectors for genome editing involving engineered endonucleases.
Kamola Saydaminova, Maximilian Richter, Philip Ng, Anja Ehrhardt, André Lieber

Adenoviruses for Vaccination
.Michael A. Barry

Use of oncolytic adenoviruses for cancer therapy.
Cristian Capasso, Manlio Fusciello, Erkko Ylösmäki, Vincenzo Cerullo