Presents in a single volume an up-to-date summary of both basic science and clinical research with actual practical consequences
Provides population-based strategies for H. pylori-associated disease management including European, Latin American, and Asian perspectives
Covers the roles of all reported virulence factors of H. pylori on pathogenesis
This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.

Table of contents (25 chapters)
Moodley, Yoshan
Pages 3-27
Adaptation of
Fischer, Frédéric (et al.)
Pages 29-56
Virulence Mechanisms of
Praszkier, Judyta (et al.)
Pages 57-87
Roles of the
Backert, Steffen (et al.)
Pages 89-111
Cover, Timothy L. (et al.)
Pages 113-141
Roles of the BabA and the SabA Adhesins in Gastroduodenal Diseases
Arnqvist, Anna
Pages 143-163
Emerging Novel Virulence Factors of
Wessler, Silja
Pages 165-188
The Primary Transcriptome and Noncoding RNA Repertoire of
Pernitzsch, Sandy R. (et al.)
Pages 189-216
Genome Evolution:
Kobayashi, Ichizo
Pages 217-231
Non-
Flahou, Bram (et al.)
Pages 233-269
Animal Models of
Solnick, Jay V. (et al.)
Pages 273-297
Müller, Anne (et al.)
Pages 299-323
The Role of Inflammatory Responses in Mouse Gastric Tumorigenesis
Oshima, Hiroko (et al.)
Pages 325-338
Influence of Host Gene Polymorphisms on Development of Gastroduodenal Diseases
McLean, Mairi H. (et al.)
Pages 339-362
Boltin, Doron (et al.)
Pages 365-385
Genta, Robert M. (et al.)
Pages 387-402
Peek, Richard M. (et al.)
Pages 403-421
Sagaert, Xavier
Pages 423-441
Koletzko, Sibylle (et al.)
Pages 443-467
Molina-Infante, Javier (et al.)
Pages 471-490
Management of
Malfertheiner, Peter (et al.)
Pages 491-502
Population-Based Strategies for
Torres, Javier (et al.)
Pages 503-517
Population-Based Strategies for
Miftahussurur, Muhammad (et al.)
Pages 519-542
Probiotics as an Alternative Therapy for
Vale, Filipa F. (et al.)
Pages 543-574
Vaccination Against
Raghavan, Sukanya (et al.)
Pages 575-60