Major depressive disorder (MDD) is the leading cause of disability globally in both developed
and developing nations. The staggering economic costs attributable to MDD are largely
a consequence of impairment in role function. Evidence indicates that disturbance in the
domain of cognitive function in individuals with MDD is the principal determinant of health
outcome. This is the first book to comprehensively explore the domain of cognition in
MDD. The literature describing cognitive dysfunction is reviewed with particular focus on
clinical determinants, pathophysiology and causative factors. The patient subpopulations
most susceptible are defined. A summary of contemporary assessment tools for research
and clinical purposes is provided. Multimodality treatments and prevention strategies are described. This book is an invaluable
resource for psychiatrists, neuropsychologists and other members of the mental health team, as well as for policy makers, vocation
rehabilitation experts, disability providers and other stakeholders interested in improving health outcomes in major depressive
disorder.
Key Features
The first book to bring together all aspects related to cognition in major depressive disorder (MDD)
The contributors are the world's experts on the topic of cognition in MDD
Covers recognition, prevention, measurement and management
Recommends neuropsychological, psychological and pharmacological approaches to management

Contents
Preface;
Part I. Clinical Relevance of Cognitive Dysfunction in
Major Depressive Disorder:
1. Does cognitive dysfunction predate the onset of
incident depression?;
2. Understanding the importance of cognitive
dysfunction and cognitive change in major
depressive disorder;
3. Cognition in MDD implications for primary care;
4. Neurocognition in pediatric depression;
5. Neuroanatomy of cognition in major depressive
disorder (hot and cold);
6. Hot and cold cognition in major depressive
disorder;
7. Social cognition and emotional processing in
major depressive disorder;
8. The role of social cognition in major depressive
disorder;
9. Are cognitive defi cits in major depressive
disorder progressive?;
10. Implications of cognitive impairments on
functional outcomes in major depressive disorder;
Part II. Underlying Biological Substrates
Associated with Cognitive Dysfunction in Major
Depressive Disorder:
11. Cognition and biomarkers in major
depressive disorder (MDD): endophenotype or
epiphenomenon?;
12. Infl ammation and cognition in major
depressive disorder;
13. HPA axis and cognitive dysfunction in mood
disorders;
14. White matter neurobiology and cognitive
dysfunction in major depressive disorder;
15. Insulin resistance and implications for
hippocampal volume/function the default mode
network;
Part III. Evaluating Cognitive Dysfunction in Major
Depressive Disorder:
16. Measuring the mind: detecting cognitive defi cits
and measuring cognitive change in patients with
depression;
17. Subjective measures of cognitive dysfunction in
major depressive disorder;
Part IV. Treatment Opportunities for Ameliorating
Cognitive Dysfunction in Major Depressive Disorder:
18. Neuroscience of functional outcomes and
treatment targets in major depressive disorder;
19. Treatment of cognitive dysfunction in adults with
major depressive disorder;
20. A novel treatment targeting cognitive dysfunction
in mood disorders;
21. Cognitive remediation for major depressive
disorder;
22. Exercise and cognition;
Index.