Offering a unique, multidisciplinary approach to the complexities of CPB, the 4th Edition of Cardiopulmonary Bypass and Mechanical Support: Principles & Practice remains the gold standard in the field. This edition brings you fully up to date with every aspects of cardiopulmonary bypass, including new information on management of pediatric patients, CPB's role with minimally invasive and robotic cardiac surgery, mechanical circulatory support, miniaturized circuits and CPB, sickle cell disease and CPB management, and much more. A newly expanded title reflects the rapidly evolving nature of extracorporeal technology, encompassing both short-term and long-term forms of cardiac and pulmonary support.

Key Features
The most comprehensive and authoritative text in the field, widely used by anesthesiologists, perfusionists, and cardiothoracic surgeons, as well as intensive care specialists, neonatologists, and interventional cardiologists.
Provides expert, full-color guidance on equipment, physiology and pathology, hematology, clinical applications, and neonates, infants, and children.
Addresses univentricular and biventricular assist devices, as well as the various forms of extracorporeal pulmonary support that may or may not include circulatory assistance.
Includes a brand-new look at the Development of Cardiopulmonary Bypass, offering an up-to-date analysis of the history of the field.
Two new co-editors, Drs. John W. Hammon and Barry D. Kussman, provide a fresh perspective and additional expertise.
Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:
Complete content with enhanced navigation
Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
Cross-linked pages, references, and more for easy navigation
Highlighting tool for easier reference of key content throughout the text
Ability to take and share notes with friends and colleagues
Quick reference tabbing to save your favorite content for future use

Table Of Contents
Section I: History
1. Development of Cardiopulmonary Bypass
Larry W. Stephenson and Frank A. Baciewicz, Jr.

Section II: Equipment
2. Blood Pumps, Circuitry, and Cannulation Techniques in Cardiopulmonary Bypass
Eugene A. Hessel and Kenneth G. Shann
3. Principles of Oxygenator Function: Gas Exchange, Heat Transfer, and Operation Yes
Mike Hines
4. Ultrafiltration and Dialysis
David M. Rothenberg
5. Short-term Uses of Mechanical Circulatory Support Devices
Jonathan Haft
6. Long-Term Uses of Mechanical Circulatory Support Devices
Joseph C. Cleveland, Jr.
7. Cardiopulmonary Bypass for Minimally Invasive Cardiac Surgery
Wiley Nifong and W. Randolph Chitwood

Section III: Physiology and Pathology
8. Temperature Management in Cardiac Surgery
Laurie K. Davies and Heather Reed
9. Surgical Myocardial Protection
Jakob Vinten-Johansen and Neil J. Thomas
10. Changes in Pharmacokinetics and Pharmacodynamics of Drugs Administered during Cardiopulmonary Bypass
Richard I. Hall and Derek Roberts
11. Endocrine, Metabolic, and Electrolyte Responses to Cardiac Surgery and Cardiopulmonary Bypass
Mark T. Nelson, Sarah K. Armour, and John F. Butterworth, IV
12. Cardiopulmonary Bypass and the Lung
Robert N. Sladen
13. Inflammatory Responses to Cardiopulmonary Bypass
Karsten Bartels and Mustafa Zakkar
14. Kidney Function and Cardiopulmonary Bypass
Anthony de la Cruz and David M. Rothenberg
15. Neurologic Effects of Cardiopulmonary Bypass
Eduardo Rodrigues and David J. Cook

Section IV: Hematology,
16. Hemodilution and Priming Solutions
John R. Cooper, Jr. and N. Martin Giesecke
17. Hematologic Effects and Coagulopathy
Andreas Pape and Kai Zacharowski
18. Coagulation Testing
Jay C. Horrow, Josef Nile Mueksch, Nicholas Weber, and Michael S. Green
19. Anticoagulation for Cardiopulmonary Bypass
Linda Shore-Lesserson
20. Heparin Neutralization
Justin Horricks and Mark E. Comunale
21.Pharmacologic Prophylaxis for Post-Cardiopulmonary Bypass Bleeding
David Mazer

Section V: Clinical Applications
22. Conduct of Cardiopulmonary Bypass
Mark Kurusz, Vincent R. Conti and Richard F. Davis
23. Primum Non Nocere: Patient Safety in Cardiopulmonary Bypass
Valerie Sera
24. Management of Unusual Problems Encountered During Procedures That Require the Use of Cardiopulmonary Bypass
Mark Kurusz, Noel L. Mills, and Richard F. Davis
25. Termination of Cardiopulmonary Bypass
Roger L. Royster, Adair Q. Locke, and Jeffrey C. Gardner
26. ECMO for Respiratory Support in Adults
Jay Zwischenberger and Ashok Babu
27. Perfusion for Thoracic Aortic Surgery
Scott A. Lemaire, Joseph S. Coselli, Steven Raskin, Terry Crane, Eric Jenkins, Murphy Rayle, Victoria Vasileiadou, and Kim I. de la Cruz

Section VI: Neonates, Infants, and Children,
28 Cardiopulmonary Bypass for the Pediatric Patient
James A. DiNardo and Gregory S. Matte
29. Myocardial Protection for Neonates and Infants
Paul J. Chai
30. Brain Injury and Neuroprotective Strategies in Pediatric Cardiac Surgery
Christopher E. Mascio and J. William Gaynor
31. Extracorporeal Membrane Oxygenation for Infants and Children
Ravi R. Thiagarajan
32. Ventricular Assist Devices for Infants and Children: State of the Art and Future
Iki Adachi and Charles D. Fraser, Jr.