This new text provides insight and treatment options for the covered disease, including dozens of high quality photographs, illustrations, and clinical tables. Topics covered include the history of the disease, categories of the disorder, molecular analysis, epidemiology, effects on body systems, disorder symptoms, and treatment. Acrodermatitis Enteropathica is a rare disorder of zinc metabolism that occurs in one of two forms: inborn and acquired. If untreated, the disease is fatal and affected individuals may die within just a few years, but since there is no cure for the condition, it is critical that physicians are aware of the signs and symptoms related to AE and the appropriate treatments available for patients. A Comprehensive Guide to Acrodermatitis Enteropathica is the only book of its kind to give insight into this rare disorder. Written by and for dermatologists, pediatric specialists, and ObGYN's, this book contains one of the largest clinical research studies done on Acrodermatitis Enteropathica over the last decade.?
Contents
Part I: Overview of Disorder
1 History of Acrodermatitis Enteropathica
2 Epidemiology and Etiology
2.1 Epidemiology
2.2 Etiology
2.2.1 Molecular Etiology of AE
2.2.2 Hypothetical Etiology 1: the Alteration of Zinc Bioavailability
2.2.3 Hypothetical Etiology 2: a Defective Zinc Transporter
2.2.4 Alternative Forms of AE-like Zinc Deficiencies
3 Analysis of Disorder
3.1 Clinical Forms of AE
3.2 Nomenclature of Zinc Deficiencies
3.3 Acquired Non-hereditary Zinc Deficiency
3.3.1 Zinc Deficient Maternal Breast Milk
3.3.2 Zinc Deficient Caused by Metabolism Disorders
4 Clinical Symptoms
5 Diagnosis
5.1 Laboratory Diagnosis of Zinc Deficiency
5.2 Histopathology
5.3 Biological Diagnosis of AE
5.4 Clinical Diagnosis
5.5 Molecular Diagnosis
5.6 Differential Diagnosis
6 Disease Course and Treatment
6.1 Treatment
Part II: Review of Roles of Zinc in Metabolism
7 The Role of Zinc in Different Body Systems
7.1 Biochemistry of Zinc Metabolism
7.2 Skin and Hair Physiology
7.3 Gastrointestinal System and Other Organs
7.4 Neurological Development, Growth, and Mental Status
7.5 Enzymes
7.6 Endocrine System
7.7 Metabolism of Nucleic Acids
7.8 Mitosis and Meiosis Cycles
7.9 Cell Membranes
7.10 Synthesis of Proteins and Collagen
7.11 Immune System
Part III: Case Descriptions of Acrodermatitis Enteropathica
8 History of AE in Adults
9 Iranian Hospital Cases in Literature
9.1 Patient One
9.2 Patient Two
9.3 Patient Three
9.4 Patient Four
9.5 Zinc Deficiency Similarities to AE in Infants (Fifth Patient)
Part IV: Acrodermatitis Enteropathica Clinical Research
10 Clinical Research
10.1 Abstract
10.2 Synopsis of Study
10.3 Purpose of Study
10.4 The Considered Hypotheses
10.5 Introduction
10.5 Methods
10.6 Ethical Considerations
10.7 Results
10.8 Discussion
11 Evaluation of Symptoms in Razi Dermatology Hospital
12 Case Photos