The largest collection of basic, clinical, and applied knowledge on the chemical senses ever compiled in one volume, the third edition of Handbook of Olfaction and Gustation encompass recent developments in all fields of chemosensory science, particularly the most recent advances in neurobiology, neuroscience, molecular biology, and modern functional imaging techniques. Divided into five main sections, the text covers the senses of smell and taste as well as sensory integration, industrial applications, and other chemosensory systems. This is essential reading for clinicians and academic researchers interested in basic and applied chemosensory perception.
The book contains predominantly black-and-white illustrations, with some color illustrations.
Table of Contents
Foreword
Preface
Contributors
Introduction and Historical Perspective

I Olfaction

A Anatomy and Neurobiology
1 Anatomy of the Human Nasal Passages 1
2 Morphology of the Mammalian Olfactory Epithelium: Form, Fine Structure, Function, and Pathology 17
3 Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism 51
4 Molecular Neurobiology of Olfactory Transduction 75
5 Neurogenesis in the Adult Olfactory Neuroepithelium 93
6 Developmental Anatomy of the Olfactory System 115
7 Anatomy and Neurochemistry of the Olfactory Bulb 139
8 Central Olfactory Structures 165
9 Sensory Physiology of Central Olfactory Pathways 181

B Functional Measurement, Ontogeny, and Genetics
10 Psychophysical Measurement of Human Olfactory Function, Including Odorant Mixture Assessment 203
11 Electrophysiological Measurement of Olfactory Function 229
12 Functional Neuroimaging of Human Olfaction 251
13 Structure-Odor Relationships: A Modern Perspective 275
14 Olfactory System Cybernetics: Artificial Noses 295
15 Olfaction and the Development of Social Behavior in Neonatal Mammals 309
16 Genetics of Olfactory Perception 329
17 Mammalian Pheromones: Fact or Fantasy? 345
18 Psychophysical Evaluation of Olfaction in Nonhuman Mammals 385
19 Methods for Determining Odor Preferences in Nonhuman Mammals 403
20 Olfactory Memory 409

C Clinical Applications and Perspectives
21 Nasal Patency and the Aerodynamics of Nasal Airflow: Measurement by Rhinomanometry and Acoustic Rhinometry, and the Influence of Pharmacological Agents 439
22 Clinical Disorders of Olfaction 461
23 Odor Perception in Neurodegenerative Diseases 479
24 Olfactory System Neuropathology in Alzheimer's Disease, Parkinson's Disease, and Schizophrenia 503
25 Multiple Chemical Intolerance 525
26 The Olfactory System and the Nasal Mucosa as Portals of Entry of Viruses, Drugs, and Other Exogenous Agents into the Brain 549
27 Influence of Environmental Toxicants on Olfactory Function 575
28 Evaluation of Olfactory Deficits by Structural Medical Imaging 593
29 Plasticity Within the Olfactory Pathways: Influences of Trauma, Deprivation, Stem Cells, and Other Factors 615
30 Head Injury and Olfaction 629

II Gustation

A Anatomy and Neurobiology
31 Saliva: Its Role in Taste Function 639
32 Morphology of the Peripheral Taste System 651
33 Central Taste Anatomy and Neurophysiology 679
34 Molecular Physiology of Gustatory Transduction 707
35 Gustatory Neural Coding 731
36 Development of the Taste System: Basic Neurobiology 759

B Functional Measurement, Ontogeny, and Genetics
37 Contemporary Measurement of Human Gustatory Function 783
38 Human Perception of Taste Mixtures 805
39 The Ontogeny of Human Flavor Perception 823
40 Genetics of Human Taste Perception 847
41 Psychophysical Evaluation of Taste Function in Nonhuman Mammals 861

C Clinical Applications and Perspectives
42 Nutritional Implications of Taste and Smell 881
43 Conditioned Taste Aversions 905
44 Clinical Disorders Affecting Taste: Evaluation and Management 935
45 Head Injury and Taste 959

III Other Chemosensory Systems

46 The Vomeronasal Organ 967
47 Trigeminal Chemosensation 981
48 The Structure and Function of the Nervus Terminalis 1001

Author Index 1027
Subject Index 1103