Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

Autophagy
Notch Pathway
PI3K/PTEN Signaling in Liver Diseases
Sirtuins
Hepcidin and Iron
Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
Oxidative Stress and Signaling in the Liver
Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.


Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Table of Contents

List of Contributors, vii

1 Hepatocytes 1
Jean-François Dufour and Joachim C. Mertens

2 Signaling pathways in biliary epithelial cells 15
M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson

3 Stellate cells 34
Alessandra Caligiuri and Fabio Marra

4 Kupffer cells 61
Amirali Kiyani and Ekihiro Seki

5 Hepatic sinusoidal endothelial cells 73
Moira B. Hilscher Robert C. Huebert and Vijay H. Shah

6 Extracellular matrix 85
Scott L. Friedman

7 Platelets: a new cell type in liver physiology 97
Mickaël Lesurtel and Pierre Alain Clavien

8 Immune cell communication in liver disease and liver regeneration 110
R. Harminder Boghal, B.F. Stephenson and Simon C. Afford

9 Extracellular vesicle RNA in liver disease 130
Tushar Patel and Hiroaki Haga

10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139
Fabienne Foufelle and Pascal Ferré

11 Autophagy 151
Hao Zhang, Bilon Khambu and Xiao Ming Yin

12 CXC chemokine receptor signaling in liver repair and regeneration 166
Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch

13 Metabolic regulation of liver regeneration 174
Jiansheng Huang and David A. Rudnick

14 TNF signaling 186
Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg

15 Fas/FasL 203
Maria Eugenia Guicciardi and Gregory J. Gores

16 Interferon signaling 214
Markus H. Heim

17 Endocannabinoid signaling in liver pathologies 226
Bostjan Humar and Nasser Semmo

18 The WNT/ catenin pathway 240
Satdarshan P. Singh Monga

19 Hedgehog signaling in the liver 262
Mariana V. Machado and Anna Mae Diehl

20 Notch pathway 275
Sonja Rothweiler and David Semela

21 PI3K/PTEN signaling in liver diseases 287
Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti

22 mTOR signaling in liver disease 314
Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall

23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326
Benoit Viollet and Marc Fortes

24 NF-?B 339
Ekihiro Seki and David A. Brenner

25 c-Jun NH2 terminal kinases in liver diseases 348
Johannes Kluwe and Robert F. Schwabe

26 p53 364
Aundrietta D. Duncan, Wen Wei Tsai and Michelle Craig Barton

27 Sirtuins 374
Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey

28 Bile acids and their receptors 385
Thierry Claudel and Michael Trauner

29 Hepcidin and iron 400
Chiara Vecchi and Antonello Pietrangelo

30 Gut microbiome and liver diseases 411
Herbert Tilg and Alexander R. Moschen

31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421
Jelena Mann and Derek A. Mann

32 Signaling in hepatocellular carcinoma 435
Adam Pennycuick and Augusto Villanueva

33 Interplay between hepatitis B virus and innate immune signaling pathways 448
Barbara Testoni, David Durantel and Fabien Zoulim

34 Signaling of hepatitis C virus 459
Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert

35 Oxidative stress and signaling in the liver 469
Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke

Index 000