Treatment of articular cartilage pathology in the knees of young and active patients is a challenging and controversial issue. Biologic Knee Reconstruction: A Surgeon's Guide is a how-to, step-by-step guide that addresses the evaluation and management of this unique patient population.
Internationally renowned cartilage experts Dr. Brian J. Cole and Dr. Joshua D. Harris, along with their contributors, present information on normal and abnormal history and physical examination. The reader will learn proper decision-making using a patient-centered approach of treatment, increasing the likelihood of a successful outcome. In addition to radiographic assessment of articular cartilage, Biologic Knee Reconstruction discusses the use of biomarkers, defect classification, and patient-reported and surgeon-measured outcomes. Aggressive nonsurgical medical management, including medications, injections, physiotherapy, and rehabilitation, is also presented.
Biologic Knee Reconstruction also discusses the management of concomitant pathologies such as malalignment, meniscal deficiency, and ligamentous instability. Selection of surgical cartilage restorative treatment options is multifactorial, requiring consideration of several patient-, knee-, and defect-specific issues. All contemporary open and arthroscopic cartilage techniques are presented in detail with high resolution figures. A unique feature of Biologic Knee Reconstruction is the presentation of several chapters discussing non-medical issues highly pertinent to the advancement and future of this field: funding of research and cost of new advanced technologies, regulation of advanced cellular, tissue, and genetic technologies, evidence-based medicine and clinical trial design and conduct, and the ethics of allograft tissues and stem cell use.
Features:
Technique preference cards from the experts performing cartilage surgery
Patient education information
The most up-to-date descriptions of advanced cartilage techniques
Unique chapters not covered in books elsewhere, including:
Biomarkers
Patient-reported outcomes assessment
Newer injection techniques (PRP, stem cells)
One- and two-stage open and arthroscopic techniques using chondrocyte- and stem cell based cell therapies
Costs and public and private funding of research
Barriers to high-quality randomized trials
Governmental regulation and availability/accessibility to patients
Gene therapy and tissue engineering
Ethics of articular cartilage surgery with stem cells, ex-vivo cell manipulation, and juvenile tissue sources
With the most up-to-date content and step-by-step methods for surgical procedures, Biologic Knee Reconstruction: A Surgeon's Guide is the perfect addition to the bookshelf of the orthopedic surgeon, cartilage researcher, sports physical therapist, or athletic trainer who evaluates and manages this unique patient population.
Contents
Dedication
Acknowledgments
About the Editors
Contributing Authors
Foreword by Lars Peterson, MD, PhD
Section I Introduction
Chapter 1 Articular Cartilage and Subchondral Bone Anatomy and Physiology
Jason J. Shin, MD; Adam B. Yanke, MD; and Nikhil N. Verma, MD
Chapter 2 Articular Cartilage and Subchondral Bone Pathology
Brian Chilelli, MD; Gloria Matthews, DVM, PhD; Tom Minas, MD; and Andreas H. Gomoll, MD
Chapter 3 Patient Evaluation: History and Physical Examination
Michael B. Ellman, MD and Charles A. Bush-Joseph, MD
Chapter 4 Preoperative Articular Cartilage and Subchondral Bone Imaging
Amit Gupta, MD; Michael C. Forney, MD; and Carl S. Winalski, MD
Chapter 5 Postoperative Articular Cartilage and Subchondral Bone Imaging
Michael C. Forney, MD; Amit Gupta, MD; and Carl S. Winalski, MD
Chapter 6 Biomarkers in Early and Post-Traumatic Osteoarthritis
Ariel M. Bodker, MD; Christian Lattermann, MD; and Susan Chubinskaya, PhD
Chapter 7 Chondral and Osteochondral Defect Classification
Jonathan M. Frank, MD and Bernard R. Bach Jr, MD
Chapter 8 Patient- and Surgeon-Reported Outcomes Assessment
Brandon Beamer, MD and Frank McCormick, MD
Section II Nonsurgical Treatment
Chapter 9 Pharmacological Treatments
Julia Bruene, MD and Kathleen Weber, MD, MS
Chapter 10 Rehabilitation and Physiotherapy
Brandon Johnson, MD and Bert R. Mandelbaum, MD, DHL (Hon)
Section III Cartilage Palliation Techniques
Chapter 11 Debridement and Chondroplasty for Focal Chondral Defects
Sanjeev Bhatia, MD; Rachel M. Frank, MD; and Brian Forsythe, MD
Section IV Cartilage Repair Techniques
Chapter 12 Subchondral Bone Treatment
Geoffrey D. Abrams, MD; Joshua D. Harris, MD; and Brian J. Cole, MD, MBA
Chapter 13 Internal Fixation for Chondral and Osteochondral Lesions
Ryan J. McNeilan, MD; David C. Flanigan, MD; and Kyle Randall, MD
Chapter 14 Microfracture, Nanofracture, PowerPick, and Abrasion Arthroplasty
Ethan Kellum, MD, MS and Kai Mithoefer, MD
Chapter 15 Enhanced Marrow-Stimulation Techniques
Rachel M. Frank, MD; Kai Mithoefer, MD; Sanjeev Bhatia, MD; and Brian J. Cole, MD, MBA
Section V Cartilage Restoration Techniques: Cell-Based Therapies
Chapter 16 Osteochondral Autograft
Adam S. Wilson, MD and Mark D. Miller, MD
Chapter 17 Fresh Osteochondral Allograft
Joshua D. Harris, MD and Brian J. Cole, MD, MBA
Chapter 18 Autologous Chondrocyte Implantation
Andreas H. Gomoll, MD
Chapter 19 Other Chondrocyte-Based Cell Therapies
Giuseppe Filardo, MD, PhD; Luca Andriolo, MD; Elizaveta Kon, MD; and Maurilio Marcacci, MD, Prof
Chapter 20 Stem Cell-Based Cell Therapies 1
Elizaveta Kon, MD; Alice Roffi, BSc; Giuseppe Filardo, MD, PhD; and Maurilio Marcacci, MD, Prof
Section VI Combined Techniques: Biologic Knee Reconstruction
Chapter 21 Malalignment Varus High Tibial Osteotomy
Francesca de Caro, MD and Annunziato Amendola, MD
Chapter 22 Malalignment Valgus Distal Femoral Osteotomy
Gregory A. Sawyer, MD and Robert F. LaPrade, MD, PhD
Chapter 23 Proximal and Distal Patellofemoral Surgery
Jack Farr, MD and Andreas H. Gomoll, MD
Chapter 24 Meniscal Deficiency: Repair and Transplantation
Peter N. Chalmers, MD; Robert A. Sershon, MD; and Brian J. Cole, MD, MBA
Section VII The Future of Articular Cartilage Surgery
Chapter 25 Costs and Research Funding: Public and Private Sources
Geoffrey S. Van Thiel, MD, MBA and Brian J. Cole, MD, MBA
Chapter 26 Governmental Regulation and Availability and Accessibility to Patients
Jonathan A. Godin, MD, MBA and Richard C. Mather III, MD, MBA
Chapter 27 Barriers to High-Quality Randomized Trials: Noninferiority to Superiority
Jaskarndip Chahal, MD, MSc, FRCSC and Ken Zaslav, MD
Chapter 28 Gene Therapy and Tissue Engineering
Laurie R. Goodrich, DVM, PhD, Diplomate ACVS
Chapter 29 Ethics of Articular Cartilage Surgery: Stem Cells, Ex Vivo Manipulation, and Juvenile Sources
H. Davis Adkisson, PhD; Philip R. Streeter, PhD; Kevin F. Bonner, MD; and Joseph Feder, PhD
Financial Disclosures
Index