The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease.
Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes.
This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Table of contents
Contributors
Preface
VOLUME 1
SECTION 1: EPIDEMIOLOGY
1 Classification of diabetes mellitus and other categories of glucose intolerance
Dianna J. Magliano, Paul Zimmet & Jonathan Shaw
2 Epidemiology and risk factors for type 1 diabetes mellitus
Andrea K. Steck & Marian J. Rewers
3 Epidemiology and geography of type 2 diabetes mellitus
Qing Qiao, Desmond E. Williams, Giuseppina Imperatore, K.M. Venkat Narayan & Jaakko Tuomilehto
SECTION 2: PHYSIOLOGY OF PANCREATIC FUNCTION
4 Development and maintenance of the islet cell
Teresa L. Mastracci, Raghavendra G. Mirmira & Ryan M. Anderson
5 Pancreatic morphology in normal and diabetic states
Rebecca L. Hull & Steven E. Kahn
6 Insulin gene expression and biosynthesis
Vincent Poitout, Roland Stein & Christopher J. Rhodes
7 -Cell biology of insulin secretion
Susumu Seino, Tadao Shibasaki & Kohtaro Minami
8 Normal -cell function
Andrea Natali, Stefano Del Prato & Andrea Mari
9 Neuropeptides and islet hormone secretion
Bo Ahrén
10 Biosynthesis, secretion, and action of glucagon
Pierre J. Lefèbvre
11 Incretin physiology in health and disease
Juris J. Meier & Michael A. Nauck
SECTION 3: NORMAL PHYSIOLOGY OF INSULIN ACTION
12 Mechanisms of insulin signal transduction
Paul R. Langlais, Lawrence J. Mandarino & W. Timothy Garvey
13 Regulation of glucose metabolism in liver
Shawn C. Burgess
14 Insulin actions in vivo: glucose metabolism
Ele Ferrannini & Ralph A. DeFronzo
15 Measuring insulin action in vivo
Richard N. Bergman & Marilyn Ader
16 Protein metabolism in health and diabetes
Elena Volpi & Jared Dickinson
17 Lipid and lipoprotein metabolism, hypolipidemic agents, and therapeutic goals
Gissette Reyes-Soffer & Henry N. Ginsberg
18 Metabolomics: applications in type 2 diabetes mellitus and insulin resistance
Sean H. Adams & John W. Newman
SECTION 4: NAFLD, NASH AND NON-TRADITIONAL ASSOCIATIONS WITH DIABETES
19 Pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Hannele Yki-Järvinen
20 Treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)
Fernando Bril, Kwame Ntim, Romina Lomonaco & Kenneth Cusi
21 Type 2 diabetes and cancer
Emily Jane Gallagher, Ruslan Novosyadlyy & Derek LeRoith
22 Diabetes and sleep apnea
Abd A. Tahrani
SECTION 5: PATHOGENESIS
23 The insulin resistance syndrome
Naveed Sattar, Paul Welsh & David Preiss
24 -Cell mass and function in human type 2 diabetes
Piero Marchetti & Ele Ferrannini
25 Pathogenesis of type 2 diabetes mellitus
Ralph A. DeFronzo
26 The genetics of type 2 diabetes
Emma Ahlqvist & Leif Groop
27 Glucose toxicity
Hannele Yki-Järvinen & Donald A. McClain
28 Monogenic disorders of the cell
Ali J. Chakera & Andrew T. Hattersley
29 Immunopathogenesis of type 1 diabetes in Western society
Alberto Pugliese
30 Molecular genetics of type 1 diabetes
M. Ann Kelly, Simon D. Rees, Anthony H. Barnett & Stephen C. Bain
SECTION 6: OBESITY
31 The relationship between obesity and type 2 diabetes the role of gut factors
Daniel S. Hsia & William T. Cefalu
32 The role of energy metabolism in the regulation of energy balance
Charmaine S. Tam & Eric Ravussin
33 Treatment of obesity: lifestyle and pharmacotherapy
Arne Astrup
34 Treatment of obesity: bariatric surgery
Karl J. Neff, Ele Ferrannini & Carel W. le Roux
35 Animal models of obesity and type 2 diabetes
David A. York, Mie Jung Park-York & Timothy Gilbertson
36 The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control
Luis Varela & Tamas L. Horvath
SECTION 7: CLINICAL TRIAL EVIDENCE IN DIABETES
37 Prevention of type 1 diabetes
Jay S. Skyler
38 Prevention of type 2 diabetes
Thomas Yates & Melanie Davies
39 Prevention of diabetic microvascular complications
Alice P.S. Kong, Nicola Brown & Juliana C.N. Chan
VOLUME 2
SECTION 8: MANAGEMENT OF DIABETES: DIET, EXERCISE AND DRUGS
40 Dietary management of diabetes mellitus in Europe and North America
Jim I. Mann & Alexandra Chisholm
41 Exercise
Henrik Galbo & Erik A. Richter
42 Sulfonylureas and meglitinides: insights into physiology and translational clinical utility
Harold E. Lebovitz & Arne Melander
43 Metformin and other biguanides: pharmacology and therapeutic usage
Susan L. Samson & Alan J. Garber
44 PPAR agonists in the treatment of diabetes
Sunder Mudaliar & Robert R. Henry
45 a-Glucosidase inhibitors
Josée Leroux-Stewart, Rémi Rabasa-Lhoret & Jean-Louis Chiasson
46 Combination therapy in type 2 diabetes mellitus
Muhammad Abdul-Ghani, Ralph A. DeFronzo & R. Eldor
47 New drugs for the treatment of diabetes mellitus
Clifford J. Bailey
48 Incretin-based therapies
Michael A. Nauck & Juris J. Meier
49 Insulin pumps
Dace L. Trence & Irl B. Hirsch
50 Innovative therapies in diabetes: colesevelam and bromocriptine
Shamsa Ali & Vivian Fonseca
SECTION 9: MANAGEMENT OF DIABETES: MONITORING AND OTHER INTERVENTIONS
51 Implantable pumps and artificial and bio-artificial pancreas system
William Tamborlane & Miladys M. Palau-Collazo
52 Pancreas and islet transplantation
R. Paul Robertson
53 Hypoglycemia and other complications of insulin therapy
Stephanie A. Amiel
54 Diabetic ketoacidosis and hyperosmolar state
Abbas E. Kitabchi, Guillermo E. Umpierrez & Mary Beth Murphy
SECTION 10: MANAGEMENT OF DIABETES: GLUCOSE AND LIPID MONITORING, SPECIFIC SUBGROUPS
55 Type 2 diabetes in obese adolescents: pathophysiology and treatment
Grace Kim & Sonia Caprio
56 Diabetes in pregnancy
Yoel Toledano, Eran Hadar & Moshe Hod
57 Aging and diabetes mellitus
Hermes Florez, Jorge Ruiz & Medha Munshi
58 Psychological problems and management of patients with diabetes mellitus
Alan M. Delamater, Ashley Marchante & Jennifer Hernandez
59 Glycated hemoglobin, serum proteins, and other markers as tools for monitoring
Susan M. Gerber, Douglas Stickle, Intekhab Ahmed & Serge Jabbour
SECTION 11: COMPLICATIONS OF DIABETES: GENERAL AND MICROVASULAR
60 Pathogenesis of diabetic microvascular complications
Josephine M. Forbes & Brooke Harcourt
61 Diabetic retinopathy and other ocular complications
Gavin S. Tan & Tien Yin Wong
62 Diabetic nephropathy
George Jerums, Elif I. Ekinci, Erosha Premaratne, Scott T. Baker, Sianna Panagiotopoulos & Richard J. MacIsaac
63 Pathology of human diabetic neuropathy
M. Mojaddidi, A.K. Sharma & Ravaz A. Malik
64 Autonomic neuropathy
Chinmay S. Marathe, Liza Phillips & Michael Horowitz
65 Connective tissue disorders in diabetes
Arlan L. Rosenbloom
66 The diabetic foot
Frank L. Bowling & Andrew J.M. Boulton
67 Erectile dysfunction in diabetes mellitus
Michael H. Cummings & Rajesh Rajendran
68 Periodontal disease and diabetes mellitus
Wenche S. Borgnakke & Robert J. Genco
SECTION 12: COMPLICATIONS OF DIABETES: MACROVASCULAR
69 Epidemiology of macrovascular disease and hypertension in diabetes mellitus
Jaakko Tuomilehto, Daiva Rastenyte, Qing Qiao & Dimitrije Jakovljevic
70 Atherogenesis, coronary heart disease and insulin resistance syndrome in diabetes
Barak Zafrir & Jorge Plutzky
71 Endothelial function and metabolic syndrome
Xinpu Chen & Sridevi Devaraj
72 Haemostatic abnormalities in diabetes mellitus
R.A. Ajjan & Peter J. Grant
73 Clinical features and treatment of coronary heart disease in diabetes
Eberhard Standl, Michael Erbach, Markolf Hanefeld, Oliver Schnell, Bernd Stratmann & Diethelm Tschoepe
74 Arterial hypertension in diabetes: etiology and treatment
Colleen Flynn & George Bakris
75 Peripheral vascular and cerebrovascular disease in diabetes mellitus
Debabrata Mukherjee
SECTION 13: DIABETES AND PUBLIC HEALTH
76 The diabetes challenge: from human and social rights to the empowerment of people with diabetes
C.T. Di Iorio, Fabrizio Carinci & M. Massi Benedetti
77 The economics of diabetes care: a global perspective
Rhys Williams
Index