Handle the toughest clinical challenges with Comprehensive Clinical Nephrology. The world's leading authorities in the field, Drs. Richard J. Johnson, John Feehally, Jürgen Floege and a team of international experts have meticulously updated this fifth edition to continue to provide the level of expert information that readers rely on from this classic reference.
NEW TO THIS EDITION

New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury.
Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management.
Hundreds of color coded algorithms promote quick reference and to help you retain concepts.
Over 400 NEW self-assessment questions and fully searchable text available online at ExpertConsult.

TABLE OF CONTENTS

Section I: Essential Renal Anatomy and Physiology

1. Renal Anatomy

2. Renal Physiology

Section II: Investigation of Renal Disease

3. Assessment of Renal Function

4. Urinalysis

5. Imaging

6. Renal Biopsy

Section III: Fluid and Electrolyte Disorders

7. Disorders of Extracellular Volume

8. Disorders of Water Metabolism

9. Disorders of Potassium Metabolism

10. Disorders of Calcium, Phosphate, and Magnesium Metabolism

11. Normal Acid-Base Balance

12. Metabolic Acidosis

13. Metabolic Alkalosis

14. Respiratory Acidosis, Respiratory Alkalosis, and Mixed Disorders

Section IV: Glomerular Disease

15. Introduction to Glomerular Disease: Clinical Presentations

16. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis

17. Minimal Change Nephrotic Syndrome

18. Primary and Secondary (Non-Genetic) Causes of Focal and Segmental Glomerulosclerosis

19. Inherited Causes of Nephrotic Syndrome

20. Membranous Nephropathy

21. Membranoproliferative Glomerulonephritis and Cryoglobulinemic Glomerulonephritis

22. Glomerulonephritis Associated with Complement Disorders

23. IgA Nephropathy and Henoch-Schonlein Nephritis

24. Antiglomerular Basement Membrane Disease and Goodpasture Disease

25. Renal and Systemic Vasculitis

26. Lupus Nephritis

27. Renal Amyloidosis and Glomerular Disease with Monoclonal Immunoglobulin Deposition

28. Other Glomerular Disorders and Antiphospholipid Syndrome

29. Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome

Section V: Diabetic Nephropathy

30. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Nephropathy

31. Prevention and Treatment of Diabetic Nephropathy

32. Management of the Diabetic Patient with Chronic Kidney Disease

Section VI: Hypertension

33. Normal Blood Pressure Control and the Evaluation of Hypertension

34. Primary Hypertension

35. Nonpharmacologic Prevention and Treatment of Hypertension

36. Pharmacologic Treatment of Hypertension

37. Evaluation and Treatment of Hypertensive Urgencies and Emergencies

38. Interventional Treatments for Resistant Hypertension

39. Renovascular Hypertension and Ischemic Renal Disease

40. Endocrine Causes of Hypertension - Aldosterone

41. Endocrine Causes of Hypertension

42. Neurogenic Hypertension, Including Hypertension Associated with Stroke or Spinal Cord Injury

Section VII: Pregnancy and Renal Disease

43. Renal Physiology in Normal Pregnancy

44. Renal Complications in Normal Pregnancy

45. Pregnancy with Preexisting Kidney Disease

Section VIII: Hereditary and Congenital Diseases of the Kidney

46. Autosomal Dominant Polycystic Kidney Disease

47. Other Cystic Kidney Diseases

48. Alport and Other Familial Glomerular Syndromes

49. Inherited Disorders of Sodium and Water Handling

50. Fanconi Syndrome and Other Proximal Tubule Disorders

51. Sickle Cell Disease

52. Congenital Anomalies of the Kidney and Urinary Tract

Section IX: Infectious Diseases and the Kidney

53. Bacterial Urinary Tract Infections

54. Tuberculosis of the Urinary Tract

55. Fungal Infections of the Urinary Tract

56. The Kidney in Schistosomiasis

57. Glomerular Diseases Associated with Infection

58. Human Immunodeficiency Virus Infection and the Kidney

Section X: Urologic Disorders

59. Nephrolithiasis and Nephrocalcinosis

60. Urinary Tract Obstruction

61. Urologic Issues for the Nephrologist

Section XI: Tubulointerstitial and Vascular Diseases

62. Acute Interstitial Nephritis

63. Primary Vesicoureteral Reflux and Reflux Nephropathy

64. Chronic Interstitial Nephritis

65. Myeloma and the Kidney

66. Thromboembolic Renovascular Disease

Section XII: Geriatric Nephrology

67. Geriatric Nephrology

Section XIII: Renal Disease and Cancer

68. Onco-Nephrology: Renal Disease in Cancer Patients

Section XIV: Acute Kidney Injury

69. Pathophysiology and Etiology of Acute Kidney Injury

70. Acute Kidney Injury in the Tropics

71. Diagnosis and Clinical Evaluation of Acute Kidney Injury

72. Epidemiology and Prognostic Impact of Acute Kidney Injury

73. Prevention and Nondialytic Management of Acute Kidney Injury

74. Dialytic Management of Acute Kidney Injury and Intensive Care Unit Nephrology

75. Management of Refractory Heart Failure

76. Hepatorenal Syndrome

Section XV: Drug Therapy in Kidney Disease

77. Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Renal Replacement Therapy

78. Herbal and Over-the-Counter Medicines and the Kidney

Section XVI: Chronic Kidney Disease and the Uremic Syndrome

79. Epidemiology, Natural History, and Pathophysiology of Chronic Kidney Disease

80. Retarding Progression of Kidney Disease

81. Clinical Evaluation and Management of Chronic Kidney Disease

82. Cardiovascular Disease in Chronic Kidney Disease

83. Anemia in Chronic Kidney Disease

84. Other Blood and Immune Disorders in Chronic Kidney Disease

85. Bone and Mineral Metabolism in Chronic Kidney Disease

86. Neurologic Complications in Chronic Kidney Disease

87. Gastroenterology and Nutrition in Chronic Kidney Disease

88. Dermatologic Manifestations of Chronic Kidney Disease

89. Acquired Cystic Kidney Disease and Malignant Neoplasms

Section XVII: Dialytic Therapies

90. Approach to Renal Replacement Therapy

91. Vascular Access for Dialytic Therapies

92. Diagnostic and Interventional Nephrology

93. Hemodialysis: Principles and Techniques

94. Hemodialysis: Outcomes and Adequacy

95. Acute Complications During Hemodialysis

96. Peritoneal Dialysis: Principles, Techniques, and Adequacy

97. Complications of Peritoneal Dialysis

98. Dialytic Therapies for Drug Overdose and Poisoning

99. Plasma Exchange

Section XVIII: Transplantation

100. Immunologic Principles in Kidney Transplantation

101. Immunosuppressive Medications in Kidney Transplantation

102. Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor

103. Kidney Transplantation Surgery

104. Prophylaxis and Treatment of Kidney Transplant Rejection

105. Medical Management of the Kidney Transplant Recipient: Infections, Malignant Neoplasms, and Gastrointestinal Disorders

106. Medical Management of the Kidney Transplant Recipient: Cardiovascular Disease and Other Issues

107. Chronic Allograft Injury

108. Recurrent Disease in Kidney Transplantation

109. Outcomes of Renal Transplantation

110. Pancreas and Islet Transplantation

111. Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Cell Transplantation