This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

Genetics and Origin of Antiphospholipid Syndrome
Soriano, Alessandra (et al.)
Pages 1-12
The Paradox of Lupus Anticoagulant
Banzato, Alessandra (et al.)
Pages 13-23
Antiphospholipid Antibody Mechanisms of Thrombosis
Meroni, Pier Luigi (et al.)
Pages 25-35
The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss
Simone, Nicoletta (et al.)
Pages 37-46
Classification Criteria for the Antiphospholipid Syndrome
Derksen, Ronald H. W. M. (et al.)
Pages 47-59
Non-classification Criteria
Gerosa, Maria (et al.)
Pages 61-74
Obstetric APS
Fredi, Micaela (et al.)
Pages 75-87
APS and the Nervous System
Chighizola, Cecilia Beatrice (et al.)
Pages 89-102
Antiphospholipid Syndrome (APS) and the Renal Involvement
Mezzina, Nicoletta (et al.)
Pages 103-112
Non-Thrombotic Hematologic Manifestations in APS
Barcellini, Wilma (et al.)
Pages 113-126
Heart and APS
Denas, Gentian (et al.)
Pages 127-150