First textbook to be devoted entirely to hypoparathyroidism
Provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism Covers a wide range of hypoparathyroid disorders Discusses novel replacement therapy with PTH 1-34 and 1-84 Includes a chapter on surgical hypoparathyroidism
This book provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism. It is exceptional in being devoted entirely to the condition and has been written at a key time as it coincides with the long-awaited arrival of replacement therapy based on parathyroid hormone (PTH) an advance that is sparking renewed interest in hypoparathyroidism. The book opens by examining the anatomy and physiology of the parathyroids before describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including various genetic forms, postoperative hypoparathyroidism, other forms of acquired hypoparathyroidism, and pseudohypoparathyroidism. Both conventional treatment and the novel replacement therapy with PTH 1-34 and 1-84 are fully addressed. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.
Table of contents
Foreword.
Preface.
1.ANATOMY AND PHYSIOLOGY OF THE PARATHYROIDS.- 1.1 The History: from Fuller Albright to the sequence of Parathyroid Hormone.- 1.2 Embriology of the parathyroid glands.- 1.3 PTH and PTH-related peptides.- 1.4 PTH assays and their clinical significance.- 1.5 Calcium-control of PTH secretion.- 1.6 Phosphate control of PTH secretion.- 1.7 Role of magnesium in Parathyroid Physiology.- 1.8 The vitamin D/FGF23/PTH axis.- 1.9 The PTH receptorsome and transduction pathways.- 1.10 G protein Gsa and GNAS imprinting.- 1.11 PTH actions on bone and kidney. - 1.12 PTH and PTHrp: non-classical target.- 1.13 In vitro cellular models of parathyroid cells.
2.HYPOPARATHYROIDISM.- 2.1 Conditions of hypoparathyroidism.- 2.2 Epidemiology of hypoparathyropidism.- 2.3 Clinical Presentation of hypoparathyroidism.- 2.4 Genetically-determined hypoparathyroidism.- 2.5 Postoperative Hypoparathyroidism.- 2.6 Other forms of acquired hypoparathyroidism radiation-induced, infiltrative disorders, heavy-metal storage disorders, post burn, maternal hyperparathyroidism.- 2.7 Refractory Hypoparathyroidism.- 2.8 Bone Features in hypoparathyroidism.- 2.9 Management of acute hypocalcemia.- 2.10 Conventional Treatment in chronic hypoparathyroidism.- 2.11 Follow-up In chronic hypoparathyroidism.- 2.12 Replacement Therapy with PTH1-34.- 2.13 Replacement Therapy with PTH1-84.
3.FUNCTIONAL HYPOPARATHYROIDISM.- 3.1.-Classification of pseudohypoparathyroidism and differential diagnosis.- 3.2 Pseudohypoparathyroidism type Ia, Pseudopseudohypoparathyroidism and Albright Hereditary Osteodistrophy.- 3.3 Pseudohypoparathyroidisms other than Ia.-3.4 Genetic Testing in pseudohypoparathyroidism.- 3.5 Blomstrand's chondrodystrophy.- 3.6 Hypoparathyroidism during magnesium deficiency or excess.