Reflects emerging concepts impacting diagnostic and therapeutic approaches
Explores background, history, epidemiology, and risk factors
Examines etiological and pathophysiological aspects
Discusses potential damage to body organs
Reviews blood pressure measurements and other diagnostic procedures
Describes pharmacological, nonpharmacological, and medical treatments
Examines hypertension in special populations and the business of hypertension treatment
Summary
Despite recent advances in healthcare, hypertension is a leading cause of death and remains a disease burden worldwide. Now in its second edition, the Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to this condition. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data.
Topics include:
Background, history, and epidemiology of hypertension
Risk factors such as pulse pressure, high heart rate, obesity, diabetes, and stress
Etiological and pathophysiological aspects, including hemodynamics and genetics
Hypertension-based damage to body organs and systems
Blood pressure measurements and other diagnostic procedures
Pharmacological, nonpharmacological, and medical treatments
Hypertension in special populations, including diabetic patients, children, during pregnancy, and post-transplant
Cost-benefit aspects of hypertension treatment and running a hypertension center
Each topic is addressed in a format that will be of interest not only to investigators and students who conduct studies on hypertension and its cardiovascular and renal complications, but also to clinicians needing in-depth information on diagnostic and therapeutic aspects. The book is an essential guide to all facets of this debilitating condition that remains a threat to public health

Background, History and Epidemiology
Epidemiology of Hypertension; Renata Cífková
The Total Cardiovascular Risk; Claudio Borghi, Arrigo Francesco Giuseppe Cicero, and Ettore Ambrosioni
Associated Risk Factors
Classical and New Risk Factors; Manolis S. Kallistratos and Athanasios J. Manolis
Pulse Pressure as a Cardiovascular Risk Factor; Athanase Benetos
Clinical Significance of High Heart Rate in Hypertension; Paolo Palatini and Guido Grassi
Obesity and Obstructive Sleep Apnea; Marzena Chrostowska, Anna Szyndler, Jacek Wolf, and Krzysztof Narkiewicz
Diabetes Mellitus; Peter M. Nilsson
Stress, Psychosocial, and Other Risk Factors in the Hypertensive Patient; Philippe Van De Borne
Blood Pressure Variability: Methodological Aspects, Pathophysiological and Clinical Implications; Gianfranco Parati, Juan Eugenio Ochoa, and Grzegorz Bilo
Antihypertensive Treatment Strategies; Giuseppe Mancia
Ethiological and Pathophysiological Aspects
Hemodynamics of Hypertension; Per Omvik and Per Lund-Johansen
Genetic Basis of Blood Pressure and Hypertension; Sandosh Padmanabhan, Mark Caulfield, and Anna F. Dominiczak
Structural Cardiovascular Changes in Hypertension; Harry A.J. Struijker-Boudier
Impaired Autonomic Cardiovascular Control in Hypertension; Guido Grassi, Gianmaria Brambilla, and Gino Seravalle
The Renin Angiotensin Aldosterone System; Ulrike M. Steckelings and Thomas Unger
Etiological and Pathophysiological Aspects of Hypertension: Other Humoral Endocrine Factors; Michel Burnier
Target Organ Damage: Measurements/Clinical Importance
Cardiac Damage and Progression to Heart Failure; E. Agabiti Rosei, M.L Muiesan, and R.E. Schmieder
Brain Damage; Cristina Sierra and Antonio Coca
Large Artery Damage: Measurement and Clinical Importance; Stéphane Laurent, and Michel E Safar
Small Artery Structure and Function in Hypertension; Anthony M. Heagerty, Sarah B. Withers, Ashley S. Izzard,
Adam S. Greenstein, and Reza Aghamohammadzadeh
Endothelial Damage: Measurement and Clinical Importance; Lorenzo Ghiadoni, Agostino Virdis, and Stefano Taddei
Renal Damage and Hypertension: Mechanisms of Renal End-Organ Damage; Hermann Haller
Retinal Changes in Hypertension; Martin Ritt, Enrico Agabiti-Rosei, and Roland E Schmieder
BP Measurements and Other Diagnostic Procedures
BP Measurements and Other Diagnostic Procedures; Jean-Philippe Baguet, Jean-Michel Mallion, and Denis L. Clement
Blood Pressure Response to Acute Physical and Mental Stress; Robert Fagard and Guido Grassi
Central Blood Pressure; Cristina Giannattasio and Stéphane Laurent
The Diagnostic Approach in Uncomplicated and Complicated Hypertension; Athanasios J. Manolis and Costas Tsioufis
Therapeutic Aspects
Blood Pressure Targets of Antihypertensive Treatment; Giuseppe Mancia and Guido Grassi
Interventional Trials in Hypertension: What Have We Learned and What Remains to be Learned? Alberto Zanchetti
The Nephroprotective Effect of Antihypertensive Treatment; Luis M. Ruilope and Julian Segura
Nonpharmacological Interventions; Stefan Engeli and Jens Jordan
Medical Treatment of Hypertension: Monotherapy and Combination Therapy; M. Burnier, G. Wuerzner and B. Waeber
Emerging Antihypertensive Drugs; Massimo Volpe and Giuliano Tocci
The Polypill; Marie Briet and Michel Azizi
Invasive Procedures; Roland E. Schmieder
Special Conditions
Clinical Management of Patients Presenting with Hypertension and Peripheral Artery Disease; Denis L. Clement
Resistant and Malignant Hypertension; Josep Redon, Fernando Martinez, and Gernot Pichtler
Hypertensive Emergencies and Urgencies; Cesare Cuspidi and Achille C. Pessina
Secondary Hypertension: Diagnosis and Treatment; Peter W De Leeuw
Hypertension in Diabetes Mellitus; Peter M. Nilsson
Hypertension in Children and Adolescents; Empar Lurbe
Hypertension in Pregnancy; Renata Cífková
Posttransplant Hypertension; Martin Hausberg and Karl Heinz Rahn
Hypertension in Patients with Renal Parenchymal Disease, Chronic Renal Failure, and Chronic Dialysis; Jose L. Rodicio and Jose A. García-Donaire
The Metabolic Syndrome in Hypertension; Josep Redon, Fernando Martinez and Maria Jose Fabia
White-Coat and Masked Hypertension; Robert Fagard
Secondary Prevention of Stroke; Miguel Camafort, Monica Doménech and Antonio Coca
Hypertension and Atrial Fibrillation: Modern Epidemiologic, Pathophysiologic, and Therapeutic Aspects; Athanasios J. Manolis, L.E. Poulimenos, J Kostis
Management of Perioperative Hypertension; Paul E. Marik
Economic and Organizational Issues
Pharmacoeconomic and Cost Benefit Aspects; Ettore Ambrosioni and Claudio Borghi
How to Organize and Run a Hypertension Center; Csaba Farsang and Margus Viigimaa
Current Problems
Blood Pressure Control in Europe; Bernard Waeber, François Feihl and Giuseppe Mancia
Hypertension in the Very Elderly; Nigel S. Beckett
Hypertension in Acute Stroke; Terence J. Quinn, John A. Goodfellow and John L. Reid
Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs; Csaba Farsang
Compliance to Treatment in Hypertension; Serap Erdine and Margus Viigimaa
Antihypertensive Treatment in Patients with Heart Failure; Nisha B. Mistry, Sverre E. Kjeldsen, and Arne S. Westheim
Residual Risk and Resistance to the Benefits of Antihypertensive Treatment; Alberto Zanchetti
Index