Begins with four basic principles of toxicology: dose matters, people differ, everything transforms, and timing is crucial
Provides practical advice, detailed methods, and protocols for students and working professionals
Presents in-depth discussions of concepts, methodologies, and assessments integral to toxicology
Includes new chapters addressing advances and developments in the field of toxicology including dose response, systems toxicology, food safety, the humane use and care of animals, and neurotoxicology
Contains an expanded glossary reflecting significant changes in the field
Summary
Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk.
The book begins with the four basic principles of toxicology dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field.
New topics in this edition include:
The importance of dose response
Systems toxicology
Food safety
The humane use and care of animals
Neurotoxicology
The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals. Readers have complimentary access to an online version of the printed book.

Table of Contents

The Wissenschaften of Toxicology: Harming and Helping through Time; Richard W. Lane
Use of Toxicology in the Regulatory Process; Barbara D. Beck, Mara Seeley, and Edward J. Calabrese
Dose Response: A Fundamental Concept in Toxicology; Edward J. Calabrese
Metabolism: A Determinant of Toxicity; Raymond A. Kemper, Mitchell E. Taub, and Matthew S. Bogdanffy
Toxicokinetics; A. Roberts and Andrew Gordon Renwick
Physiologically Based Pharmacokinetic and Toxicokinetic Models; Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen
Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology; Julia Hoeng, Marja Talikka, Florian Martin, Sam Ansari, David Drubin, Ashraf Elamin, Stephan Gebel,
Nikolai V. Ivanov, Renée Deehan, Ulrike Kogel, Carole Mathis, Walter K. Schlage, Alain Sewer, Nicolas
Sierro, Ty Thomson, and Manuel C. Peitsch
Toxicologic Assessment of Pharmaceutical and Biotechnology Products; Michael A. Dorato, Carl L. McMillian, and Tracy M. Williams
Statistics and Experimental Design for Toxicologists; Shayne C. Gad
Practice of Exposure Assessment; Dennis J. Paustenbach and Amy K. Madl
Epidemiology for Toxicologists; Geary W. Olsen, John L. Butenhoff, and Ralph R. Cook
Principles of Pathology for Toxicology Studies; Steven R. Frame, Peter C. Mann, and Jessica M. Caverly Rae
The Information Infrastructure of Toxicology; Philip Wexler, Fred Berman, Patricia Nance, Ann Parker, and Jacqueline Patterson
Agents
Food Safety and Foodborne Toxicants; Claire L. Kruger, Chada S. Reddy, Dietrich B. Conze, and A. Wallace Hayes
Solvents and Industrial Hygiene; David L. Dahlstrom and John E. Snawder
Crop Protection Chemicals: Mechanism of Action and Hazard Profiles; James T. Stevens, Trent D. Stevens, and Charles B. Breckenridge
Metals; Janis E. Hulla
Radiation Toxicity; Roger O. McClellan
Plant and Animal Toxins; Frederick W. Oehme, Daniel E. Keyler, and A. Wallace Hayes
Methods
Humane Care and Use of Laboratory Animals in Toxicology Research; Dale M. Cooper, Lisa Craig, Christopher N. Papagiannis, Duane W. Poage, Gregory W. Ruppert,
and David G. Serota
Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies; William S. Stokes
Acute Toxicity and Eye Irritancy; Ping Kwong (Peter) Chan and A. Wallace Hayes
Genetic Toxicology; David J. Brusick and Wanda R. Fields
Short-Term, Subchronic, and Chronic Toxicology Studies; Daniel T. Wilson, Jerry F. Hardisty, Johnnie R. Hayes, and Nelson H. Wilson
Carcinogenicity of Chemicals: Assessment and Human Extrapolation; Gary M. Williams, Michael J. Iatropoulos, Harald G. Enzmann, and Ulrich F. Deschl
Principles of Clinical Pathology for Toxicology Studies; Robert L. Hall and Nancy E. Everds
Dermatotoxicology; Benjamin B. Hayes, Esther Patrick, and Howard J. Maibach
Inhalation Toxicology; Joseph D. Brain, Wolfgang G. Kreyling, and John J. Godleski
Detection and Evaluation of Chemically Induced Liver Injury; Gabriel L. Plaa, Michel Charbonneau, and Isabelle Plante
Principles and Methods for Renal Toxicology; Lawrence H. Lash
Gastrointestinal Toxicology; Robert W. Kapp, Jr.
Pathophysiology and Toxicology of the Heart; Khalid Almuti, Shahid Rahman, and Daniel Acosta, Jr.
Neurotoxicology; Stephanie J.B. Fretham, Samuel Caito, Ebany J. Martinez-Finley, Gennaro Giordano, Lucio G. Costa,
and Michael Aschner
Assessment of Male Reproductive Toxicity; Gary R. Klinefelter and D.N. Rao Veeramachaneni
Test Methods for Assessing Female Reproductive and Developmental Toxicology; Raymond G. York, Robert M. Parker, and Lynne T. Haber
Hormone Assays and Endocrine Function; Robert M. Parker and Raymond G. York
Immunotoxicology: The Immune System Response to Toxic Insult; Robert V. House, Michael I. Luster, Jack H. Dean, and Victor J. Johnson
Assessment of Behavioral Toxicity; Deborah A. Cory-Slechta and Bernard Weiss
Organelles as Tools in Toxicology: In Vitro and In Vivo Approaches; Bruce A. Fowler, Joseph R. Landolph, Jr., Kathleen Sullivan, and A. Wallace Hayes
Analysis and Characterization of Enzymes and Nucleic Acids Relevant to Toxicology; F. Peter Guengerich
Modern Instrumental Methods for Studying Mechanisms of Toxicology; Peter A. Crooks, Howard P. Hendrickson, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell
Methods in Environmental Toxicology; Anne Fairbrother, Mace G. Barron, and Mark S. Johnson
Glossary
Index