This volume of The Year in Immunology series features reviews of
topics in human immunology, including B1 B cells, BCL-2 family members,
Wiskott-Aldrich syndrome, reverse vaccinology, anti-b2-glycoprotein
I, the role of autoimmunity In thromboangiitis obliterans (Buerger's
Disease), long pentraxin PTX3 as a paradigm for humoral pattern
recognition molecules, and control of inflammatory heart disease by CD4+ T cells.

Table of Contents
The proper study: preface to The Year in Immunology v
Noel R. Rose

The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules 1
Alberto Mantovani, Sonia Valentino, Stefania Gentile, Antonio Inforzato, Barbara Bottazzi, and Cecilia Garlanda

The role of autoimmunity in thromboangiitis obliterans (Buerger's disease) 15
Siva S. Ketha and Leslie T. Cooper

Wiskott-Aldrich syndrome: a comprehensive review 26
Michel J. Massaad, Narayanaswamy Ramesh, and Raif S. Geha

Anti- 2-glcoprotein I antibodies 44
Rohan Willis and Silvia S. Pierangeli

Getting away with murder: how does the BCL-2 family of proteins kill with immunity? 59
Thibaud T. Ranault and Jerry E. Chipuk

Control of inflammatory heart disease by CD4+ T cells 80
Jobert G. Barin and Daniela Ciháková

Human B-1 cells take the stage 97
Thomas L. Rothstein, Daniel O. Griffin, Nichol E. Holodick, Tam D. Quach, and Hiroaki Kaku

Reverse vaccinology in the 21st century: improvements over the original design 115
Claudio Donati and Rino Rappuoli

The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress 133
Howard B. Dickler, J. Philip McCoy, Robert Nussenblatt, Shira Perl, Pamela A. Schwartzberg, John S. Tsang, Ena Wang, and Neil S. Young