Muscle Biopsy: A Practical Approach serves as a succinct but comprehensive reference for pathologists and neurologists in practice and in training that skilfully guides them through the complexities of diagnosing muscle biopsy specimens and highlights their implications for clinical treatment. The authors are all internationally known for their work on muscle disease and this practical reference work successfully bridges the gap between clinical syndromes and disorders and their underlying pathologies. This practical text distils a wealth of experience by focusing on the most important elements of etiology, pathogenesis and pathological appearance.
Key Features
Covers the entire range of diagnostic and investigative techniques in order to provide the reader with all of the tools needed to formulate an accurate diagnosis.

Approximately 600 high-quality colour images throughout provide the user with a comprehensive visual guide to recognition and interpretation.

Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis.

Presents all of the latest, clinically relevant techniques in immunohistochemistry and molecular genetics as they apply to individual disorders.

Enhanced use of brilliantly simple diagrams and tables that illuminate the genetics of muscular dystrophies.

Features convenient online access to the full text and all of the images at expertconsult.com


Section 1 The Biopsy: Normal and Diseased Muscle

1. The procedure of muscle biopsy

2. Histological and histochemical stains and reactions

3. Normal muscle

4. Definition of pathological changes seen in muscle biopsies

5. Ultrastructural changes in diseased muscle

6. Immunohistochemistry

7. How to read a biopsy


Section 2 Pathological Muscle: Individual Diseases

8. Classification of neuromuscular disorders

9. Neurogenic disorders

10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy

11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies

12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies

13. Muscular dystrophies and allied disorders IV: Emery? Driefuss muscular dystrophies and Bethlem myopathy

14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy

15. Congenital myopathies

16. Myofibrillar myopathies

17. Metabolic myopathies I: glycogenoses

18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies

19. Endocrine disorders

20. Ion channel disorders

21. Myasthenic syndromes

22. Inflammatory myopathies

23. Toxic and drug-induced myopathies
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Appendix 1. Glossary of commonly used terms
eferences
Index