This work provides an overview of psychoneuroimmunology, the most integrative health science discipline, which focuses on the biological processes at all levels that operate to sustain health in the face of diverse challenges posed by changing environments.

INDICE: 1. Introduction 2. Historical antecedents 3. Immune system basics 4. Endocrine-immune modulation 5. Neuroimmune modulation 6. Stress, contextual change, and disease 7. Psychosocial stress 8. Infection, allergy and psychosocial stress 9. Cancer, autoimmunity and psychosocial stress 10. Immune activity and psychopathology 11. Immune function enhancement 12. Integration and implications