A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease.
Key features:

New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment
Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers
Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials
Photomicrographs present normal and abnormal blood cells from a variety of hematological conditions along with descriptive text.

CONTENTS:

Foreword vii
Introduction ix
Dedication xi
Acknowledgments xiii
1 Rodents 1
Mouse 1
Introduction 1
Blood picture 1
Typical ranges (Siemens Advia 120) 2
Hamster 15
Introduction 15
Blood picture 15
Guinea Pig 17
Introduction 17
Blood picture 17
Rat - Sprague Dawley (SD)/Han Wistar (HW) 18
Introduction 18
Blood picture 18
Typical ranges (Siemens Advia 120) 19
References 36
2 Rabbit 37
Introduction 37
Blood picture 37
References 39
3 Cat 41
Introduction 41
Blood picture 41
References 44
4 Dog 45
Introduction 45
Blood picture 45
Typical ranges (Siemens Advia 120) 46
References 64
5 Monkey 65
Introduction 65
Blood picture 65
Marmoset 66
Cynomolgus 71
Introduction 71
Blood picture 71
Typical ranges (Siemens Advia 120) 72
Baboon 84
Rhesus Monkey 86
References 87
6 Other species 89
Pig 89
Introduction 89
Blood picture 89
Horse 91
Introduction 91
Blood picture 91
Goat and Sheep 94
Assorted Other Species 96
References 103
7 Blood collection procedures 105
Common bleeding sites 105
Anticoagulants 105
Staining 105
8 Artifacts 107
Collection artifacts 107
Sample transport and storage 109
Anticoagulant 110
Storage artifacts 111
Blood smear preparation 113
Stain precipitate 113
References 114
9 Bone marrow 115
Introduction 115
Review of marrow sampling techniques 115
Recommended methods for marrow sampling 116
Preparation and staining of smears 118
Evaluation 119
Interpretation 119
References 120
10 Comparative applications in flow cytometry 121
Application of fl ow cytometry in comparative hematology 122
References 132
Index 135