New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.

Features
Includes comprehensive diagnosis, risk assessment and treatment of all subtypes of childhood leukemias, aiding accurate management of children with leukemia
Contains numerous high-quality figures and tables, enabling quick learning
Describes the most up-to-date clinical, translational and basic research in leukemia, and addresses future directions
Table of Contents
Preface
Part I. History and General Issues:
1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel
2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui
3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison
Part II. Cell Biology and Pathobiology:
4. Immunophenotyping Fred G. Behm
5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak
6. Cytogenetics of acute leukemias Susana C. Raimondi
7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan
8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing
9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero
10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters
11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange
Part III. Evaluation and Treatment:
12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans
13. Acute lymphoblastic leukemia Ching-Hon Pui
14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg
15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu
16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro
17. Relapsed acute myeloid leukemia Ursula Creutzig
18. Myelodysplastic syndromes Henrik Hasle
19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli
20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock
21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman
22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher
23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui
24. Antibody-targeted therapy Alan S. Wayne
25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop
26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner
27. Development therapeutics Sima Jeha
28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen
Part IV. Complications and Supportive Care:
29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui
30. Late complications after leukemia therapy Melissa Hudson
31. Therapy-related leukemias Carolyn A. Felix
32. Infectious complications Hana Hakim and Patricia M. Flynn
33. Hematologic supportive care Fariba Navid and Victor M. Santana
34. Pain management Doralina L. Anghelescu and Roland Kaddoum
35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull
36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard
Index