Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
Includes evaluation of vaccine efficacy and safety
Details clinical trial design, including regulatory requirements
Discusses the emerging field of active cellular immunotherapy
Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, teachers and postdoctoral fellows working in the field of vaccines

List of Contributors
Preface

Part 1: Introduction

1 Concept & Scope of Modern Vaccines
Nadeem Sheikh PhD, Huw Davies PhD, Clint Schmidt PhD

Part 2: Principles of Vaccine Design

2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants
Heather L. Wilson PhD, Scott Napper PhD, George K. Mutwiri, Sylvia van Drunen-Little van den Hurk, Hugh Townsend PhD VIDO, Lorne A. Babiuk PhD, Andrew A. Potter PhD, Volker Gerdts PhD

3 Antigen Processing and Presentation by MHC Class I, II and Non-Classical Molecules
Anthony N. Antoniou PhD, Izabela Lenart, David B. Guiliano, Simon J. Powis PhD

4 Understanding the Mucosal Immune System for Better Mucosal Vaccine
Janine Bilsborough PhD, Joanne L. Viney PhD

5 Immunological Memory: T Cells in Humans
Maria Candela Iglesias, Victor Appay PhD, Arnaud Moris,

6 Immunological Memory: B Cells
Frances Eun-Hyung Lee MD, Iñaki Sanz MD

7 Utility of Mouse Models in Vaccine Design and Development
Catherine M. Bosio PhD, Megan McLeod PhD, Philippa Marrack PhD, Ross M. Kedl

8 Utility of Non-Human Primate Models for Vaccine
Preston A. Marx PhD, Alexander F. Voevodin

Part 3: Antigen Discovery (Macro approach vs. Epitope focused)

9 Sequence Based Computational Approaches to Vaccine Discovery and Design
Darrick Carter PhD

10 High-Throughput Proteomics (Microarrays only)
Huw Davies PhD

11 Phage Libraries
Aaron K. Sato PhD

Part 4: Antigen Engineering

12 Attenuated Microbial Vaccines
Richard W. Titball BSc, FRCPath, Helen S. Atkins BSc, PhD

13 Virus-Like Particles as Antigen Scaffolds
Bryce Chackerian PhD, John T. Schiller PhD

14 Recombinant MVA Vaccines, Optimisation, Pre-clinical and Product Development
Yper Hall BSc, Miles Carroll PhD

15 Recombinant Adenoviruses for Vaccination
Nelson Cesar Di Paolo PhD, Dmitry Shayakhmetov PhD, André Lieber MD, PhD

16 Recombinant Avipoxviruses
Michael A. Skinner PhD, Stephen M. Laidlaw

17 Intracellular Facultative Bacterial Vectors For Cancer Immunotherapy
Patrick Guirnalda , Laurence Wood, Matthew Seavy, Yvonne Paterson PhD

18 Nucleic Acid Vaccination
Britta Wahren, Margaret A. Liu MD

19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens
Matthew F. Mescher PhD, Julie M. Curtsinger

Part 5: Delivery Systems

20 Transcutaneous Immunization via Vaccine Patch Delivery System
Robert C. Seid PhD, Gregory M. Glenn MD

21 Needle-free Jet Injection for Vaccine Administration
Brian R. Sloat, Hoi K. Tran, Zhengrong Cui PhD

22 Oral Vaccines: an old need and some new possibilities
Amit A. Lugade PhD, Kalathil Suresh PhD, Yasmin Thanavala PhD

23 Adjuvants: From Serendipity to Rational Discovery
Derek T. O'Hagan PhD, Andreas Wack PhD

24 Immunostimulatory Properties of Biodegradable Microparticles
F.A. Sharp, E.C. Lavelle

25 Co-administration of Costimulatory Moieties
Carolina Arancibia, Yvette Latchman PhD

26 Toll Receptors in Relation to Adjuvant Effects
Dipshikha Chakravortty PhD, Amit Lahiri PhD, Priyanka Das PhD

Part 6: Regulatory Considerations

27 Regulatory Issues (FDA & EMEA)
Murrium Ahmad PhD, Victoria Byers, Peter Wilson

Part 7: Evaluating Vaccine Efficacy

28 Immune Monitoring Design within the Development Pipeline for an Immunotherapeutic or Preventive Vaccine
Sylvia Janetzki PhD, Pedro Romero MD, Mario Roederer PhD, Diane L. Bolton PhD, Camilla Jandus

29 Clinical Development Strategy: Nuts and Bolts
Candida Fratazzi MD, Claudio Carini MD, PhD

30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification
Robert C Rees PhD, Stephanie Laversin, Cliff Murray PhD, Graham Ball PhD

Part 8: Implementing Immunizations/Therapies

31 Mass Immunization Strategies
David L. Heymann MD, DTM&H, Bruce R. Aylward, Rudolf H. Tangermann

32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making
Marie-Claude Boily PhD, Marc Brisson PhD, Benoit Mâsse PhD, Sir Roy M Anderson FRS, FMedSci

33 Vaccine Safety
John Iskander MD, MPH, Claudia Vellozzi MD, MPH, Jane Gidudu MD, MPH, Robert T. Chen MD, MA