Designed for both neurologists and non-neurologists, Multiple Sclerosis: Diagnosis and Therapy takes a practical approach to the most current principles of diagnosis and management of this complex disease. Editors and authors from Harvard Medical School have contributed up-to-date therapeutic information for the various stages and types of MS and also provide the necessary background regarding the pathogenesis of the disease.


List of Contributors, vii
Preface, ix

Part I Pathology and Diagnosis, 1

1 Disease Pathogenesis, 3
Roopali Gandhi and Howard L. Weiner

2 Biomarkers, 26
Manuel Comabella and Samia J. Khoury

3 Epidemiology and Genetics, 56
Philip L. De Jager

4 Diagnosis, 77
James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle

5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101
Tanuja Chitnis

6 Magnetic Resonance Imaging in Multiple Sclerosis, 136
Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi

7 Predicting Clinical Course, 163
Brian Healy and Maria Liguori

Part II Management, 181

8 Medication Treatment in Multiple Sclerosis, 183
James M. Stankiewicz and Samia J. Khoury

9 Symptom Management, 213
Lynn Stazzone and Brandon Brown

10 Cognitive Dysfunction in Multiple Sclerosis, 239
Bonnie I. Glanz and Maria K. Houtchens

11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263
David J. Rintell

12 Future Therapeutic Approaches, 283
Howard L. Weiner and Laura Edwards

Index, 301