Acute lymphoblastic leukemia (ALL) is a malignant disorder of the bone marrow in which a lymphoid precursor cell becomes genetically altered resulting in dysregulated proliferation and clonal expansion of neoplastic cells. It is the most common malignancy in children, representing nearly one third of all pediatric cancers. In this book, the authors present topical research in the study of acute lymphoblastic leukemia including genome wide association studies in pediatric acute lymphoblastic leukemia; mice deficient for the Slp65 signaling protein which is a model for ALL; histone deacetylase inhibitors and maintenance therapy in Ph negative adult acute lymphoblastic leukemia.

Table of Contents:
Preface

Genome Wide Association Studies in Pediatric Acute Lymphoblastic Leukemia: Pathogenesis and Therapy
(Kyriaki Hatziagapiou, Maria Braoudaki, Katerina Katsibardi, George I. Lambrou, Fotini Tzortzatou-Stathopoulou, Hematology/Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece, and others)

Mice Deficient for the Slp65 Signaling Protein: A Model for Pre-B Cell Acute Lymphoblastic Leukemia
(Van B.T. Ta, Rudi W. Hendriks, Department of Pulmonary Medicine, Erasmus MC Rotterdam, The Netherlands)

Childhood Acute Lymphoblastic Leukemia
(Adriana Zámecníkova, Kuwait Cancer Control Center, Department of Hematology, Laboratory of Cancer Genetics, Kuwait)

Systems Approaches to Childhood Leukemogenesis
(George I. Lambrou, Maria Braoudaki, Kyriaki Hatziagapiou, Katerina Katsibardi, Fotini Tzortzatou-Stathopoulou, Hematology/Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece, and others)

Histone Deacetylase Inhibitors: Pre-Clinical and Clinical Evidence in Treating Acute Lymphoblastic Leukemia
(Ana Lucia Abujamra, Children's Cancer Institute, Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, Brazil, and others)

A Therapeutic Target in Leukemia: The NK-1 Receptor
(Miguel Muñoz, Ana González-Ortega, Rafael Coveñas, Research Laboratory on Neuropeptides, Virgen del Rocío University Hospital, Sevilla, Spain, and others)

Minimal Residual Disease Monitoring in Childhood Acute Lymphoblastic Leukemia
(Katerina Katsibardi, Maria Braoudaki, George I. Lambrou, Kyriaki Hatziagapiou, Fotini Tzortzatou-Stathopoulou, Hematology/Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece, and others)

Clinical Relevance and Application of Cytogenetic Approaches in Pediatric Acute Lymphoblastic Leukaemia
(Maria Braoudaki, Katerina Katsibardi, George I. Lambrou, Kyriaki Hatziagapiou, Fotini Tzortzatou-Stathopoulou, University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece, and others)

Maintenance Therapy in Ph Negative Adult Acute Lymphoblastic Leukemia
(Michael Doubek, Jirí Mayer, Department of Internal Medicine, Hematology/Oncology, University Hospital, Jihlavska, Brno, Czechia)

The Role of Innate and Adaptive Immunity in Childhood Acute Lymphoblastic Leukemia
(Maria Hatzistilianou, Aristotle University of Thessaloniki, Agiou Ioannou, Kalamaria, Thessaloniki, Greece)

Index