The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters.

Given the multidisciplinary nature of the field, the book is broken into six different sections: 'Molecular Imaging technologies', 'Chemistry', 'Molecular Imaging in Cell and Molecular Biology', 'Applications of Molecular Imaging', 'Molecular Imaging in Drug Evaluation' with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.


Part I: Molecular Imaging Technologies

1: Imaging of structure and function with PET/CT
2: PET/MRI
3: SPECT and SPECT/CT
4: Principles of micro x-ray computed tomography
5: Small Animal SPECT, SPECT/CT, and SPECT/MRI
6: Instrumentation and methods to combine small animal PET with other imaging modalities
7: Functional Imaging using Bioluminescent Imaging
8: Optical Multimodality
9: Fiber Optic Fluorescence Imaging
10: Fluorescence Tomography
11: Endomicroscopy
12: Intravital Microscopy
13: Diffuse Optical Tomography
14: Ultrasound
15: Molecular Photoacoustic Tomography
16: Optical Projection Tomography
17: Signal Post Processing/Image Reconstruction

Part II: Chemistry of Molecular Imaging

18: Chemistry of Molecular Imaging: an overview
19: Radiochemistry of PET
20: Radiochemistry of SPECT
21: Nanochemistry for Molecular Imaging
22: Newer Bioconjugation Methods
23: Targeted Antibodies and Peptides
24: Hyperpolarized 13C magnetic resonance imaging ' Principles and applications
25: MR Imaging Agents
26: Optical Imaging Agents
27: Ultrasound Contrast Agents
28: Multimodality Agents
29: 'Click Chemistry': Applications to Molecular Imaging
30: The 'One-Bead-One-Compound' Combinatorial Approach to Identifying Molecular Imaging Probes
31: Chemical Biology Approaches to Molecular Imaging
32: Theranostics: Agents for diagnosis and therapy
33: Magnetic Nanoparticles
34: Fluorocarbon Agents For Quantitative Multimodal Molecular Imaging and Targeted Therapeutics
35: Aptamers for Molecular Imaging
36: Toxicology

Part III: Molecular Imaging in Cell & Molecular Biology

37: Overview of Molecular and Cell Biology
38: Systems Biology
39: Protein Engineering
40: Phage Display for Agent Development
41: Molecular Imaging of Gene Therapy
42: Developing diagnostic and therapeutic viral vectors
43: Cell Voyeurism using Magnetic Resonance Imaging
44: Tumor vasculature
45: Hypoxia Imaging
46: Protein-Protein Interaction
47: Fluorescence Reporters/Activatable Cell Penetrating Peptides
48: Imaging of Signaling Pathways

Part IV: Applications of Molecular Imaging

49: Molecular and Functional Imaging of the Tumor Microenvironment
50: Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas
51: PET Diagnosis and Response Monitoring in Oncology
52: MRS Treatment Response and Detection
53: MRI Treatment Response Assessment ' Diffusion
54: Myocardial Metabolism
55: Congestive Heart Failure
56: Molecular Imaging of Atherosclerosis
57: Thrombosis and Embolism
58: Molecular Imaging of Stem Cells in Myocardial Infarction
59: Central Nervous System Molecular Imaging
60: Neuroreceptor Imaging
61: Neurodegeneration
62: Molecular Imaging of Autoimmune Diseases
63: Rheumatoid Arthritis
64: Autoimmune Diabetes
65: Imaging in Asthma

Part V: Molecular Imaging in Drug Evaluation

66: Molecular and Functional Imaging in Drug Development
67: PET Imaging Clinical Trials
68: MR Imaging in Clinical Trials
69: Imaging of Gene Therapy: Basis and Clinical Trials

Part VI: Other

70: Visualization
71: Quantification of Radiotracer Uptake into Tissue
72: Mining High Throughput Data for Candidate Biomarkers as Imaging and Therapeutic Targets
73: Pharmacokinetic Modeling
74: Cost-Effectiveness Analysis/Economics of Probe Development
75: Regulatory and Reimbursement Process for Imaging Agents and Devices