Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

Table of Contents
Overview Josh Fidler
1. Introduction to basic research Harold Moses
Part I. Basic Research: 2. Animal models of metastasis Janet Price
3. Non-traditional models of metastasis including drosophilia Elisa Woodhouse
4. Computational models of metastasis Wayne Kendal
5. Metastatic inefficiency and tumor dormancy Ann Chambers
6. The role of the epithelial-mesenchymal transition (EMT) and MET in metastasis Erik Thompson, Donald Newgreen and Lilian Soon
7. Proteolytic pathways in metastasis Johanna Joyce
8. The role of matrix metalloproteinases in tumor invasion and metastasis Barbara Fingleton
9. The role of the urokinase system in invasion and metastasis Julio Aguirre-Ghiso
10. Apoptotic and anoikis mechanisms controlling steps of the metastatic cascade Kounosuke Watabe
11. Intra-vital video microscopy to visualize invasion and metastasis Erik Sahai
12. The influence of inflammation and chemokines in metastasis Michael Karin
13. How aging and cellular senescence influences metastasis Futoshi Okada and Hiroshi Kobayashi
14. Hematopological vs. lymphatic metastasis: a comparison of tumor cell interactions with vascular vs. lymphatic endothelium Marc Achen, Steven Stacker and Tara Karezis
15. The role of microparticles in metastasis Hector Peinado and Bethan Psaila
16. Endothelial-specific markers that determine organ-specificity of metastasis Renata Pasqualini
17. Mechanisms of organ selectivity Yibin Kang
18. Growth regulatory pathways that determine organ selectivity of metastasis Suzanne Eccles
19. The pre-metastatic niche Mariannna Papaspyridonos and Rosandra Kaplan
20. Metastasis-promoting genes Paul Fisher
21. Metastasis-suppressor genes Patricia Steeg and Carrie Rinker-Schaeffer
22. Epigenetic regulation of metastasis Manel Esteller
23. Host determinants of metastatic potential Nigel Crawford
Part II. Clinical Research: 24. Introduction to clinical section Nancy E. Davidson
25. Sarcomas Lee Helman and Chand Khanna
26. Neuroblastoma Nai Kong Cheung
27. Retinoblastoma David Abramson
28. Primary brain tumors and cerebral metastases Mitchel Berger
29. Head and neck Ketayun Dinshaw
30. Melanomas John Kirkwood
31. Gastric Yasuhide Yamada
32. Pancreas José Eduardo Monteiro Cunha
33. Liver (primary and hepatic metastases) Zhao-you Tang
34. Colon Andrea Wang-Gillam
35. Lung Rafael Rosell-Costa
36. Thyroid Michael Tuttle
37. Kidney cancer metastasis Jean Jacques
38. Bladder Dan Theodorescu
39. Myeloma/lymphoma G. David Roodman
40. Breast metastasis Heather L. McArthur, Clifford A. Hudis and Patrick Morris
41. Obgyn S. Diane Yamada
42. Prostate cancer metastasis Kenneth Pienta
43. Testicular and germ cell Robert Hromas
44. Proteomics and molecular markers Lance Liotta
45. Bone marrow/MRD Klaus Pantel
46. Sentinel lymph nodes Jeffrey Gershenwald
47. Molecular imaging and metastasis Lily Wu
48. Complications of bone metastases including nerve pain Robert E. Coleman
49. Coagulation Simon Karpatkin and David Green
50. Nanoparticles P. Charles Lin
51. Metronomics Robert Kerbel
52. Therapeutics Paul Elvin
53. Immunotherapy Pier-Luigi Lollini, Patrizia Nanni and Carla DeGiovanni
54. Radiotherapy Hak Choy
55. Regulatory issues surrounding clinical trials of anti-metastatic therapies George W. Sledge, Jr.