The book is laid out in 6 sections:

1. Preclinical Approaches to Face Transplantation

2. Clinical Aspects in Preparation to Face Transplantation in Humans

3. Approval Process of Face Transplantation in Humans

4. Social and Public Relations in Face Transplantation

5. World Experience with Face Transplantation in Humans

6. Future Directions in Face Transplantation

This book spans the entire process of a face transplantation, from detailing the anatomy of the face to considering the social and ethical challenges of the procedure. This rigorous presentation of face transplantation also includes the anesthesia involved, the role of Institutional Review Boards in approving the operation, the financial aspects and media response. Since the authorship is international, the book considers the different perspectives, approaches and responses from across the world.

Part I Preclinical Aspects of Face Transplantation
1 Face as an Organ: The Functional Anatomy of the Face . . . . . . . . . . 3
Maria Z. Siemionow and Erhan Sonmez
2 The Face as a Sensory Organ. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Maria Z. Siemionow, Bahar Bassiri Gharb, and Antonio Rampazzo
3 Immunological Aspects of Face Transplantation. . . . . . . . . . . . . . . . . 25
Aleksandra Klimczak and Maria Z. Siemionow
4 Experimental Studies in Face Transplantation: Rodent Model. . . . . 41
Maria Z. Siemionow and Fatih Zor
5 Experimental Studies in Face Transplantation: Swine Model. . . . . . 55
Yur-Ren Kuo
6 Experimental Studies in Face Transplantation: Primate Model . . . . 63
Eduardo D. Rodriguez, Gerhard S. Mundinger, Rolf N. Barth,
Helen G. Hui-Chou, Steven T. Shipley, Luke S. Jones,
and Stephen T. Bartlett
7 Timeline and Evolution of Face Transplant Cadaver Models . . . . . . 73
Chad R. Gordon and Maria Z. Siemionow
Part II Clinical Aspects in Preparation for Face Transplantation
8 Guidelines and Technical Aspects in Face
Composite Tissue Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Frank Papay
9 Anesthetic Care for Face Transplantation. . . . . . . . . . . . . . . . . . . . . . 95
Jacek B. Cywinski, D. John Doyle, and Krzysztof Kusza
10 Alternative Approaches to Face Transplantation:
Microsurgical Approach. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
Elliott H. Rose
Contents
xii Contents
11 Multi-staged Autologous Reconstruction of the Face . . . . . . . . . . . . . 119
Lawrence J. Gottlieb and Russell R. Reid
12 Ethical Aspects of Face Transplantation . . . . . . . . . . . . . . . . . . . . . . . 131
George J. Agich
13 Psychological Aspects of Face Transplantation. . . . . . . . . . . . . . . . . . 139
Kathy L. Coffman, Chad R. Gordon, and Maria Z. Siemionow
14 Physical Medicine and Rehabilitation after Face Transplantation . . 151
Pamela L. Dixon, Xiaoming Zhang, Mathieu Domalain,
Ann Marie Flores, and Vernon W.-H. Lin
15 Prosthetic Support in Face Transplantation. . . . . . . . . . . . . . . . . . . . . 173
Michael L. Huband
Part III Monitoring Aspects of Face Transplantation
16 Immunological Monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
Medhat Askar
17 A Single Institution's Experience With Diagnosing Acute
Cellular Rejection in Facial Allotransplantation. . . . . . . . . . . . . . . . . 193
Jason S. Stratton and Wilma F. Bergfeld
18 Classification of Face Rejection: Banff classification for CTA. . . . . . 199
Jean Kanitakis and Linda C. Cendales
19 Brain Plasticity After Hand and Face Allotransplantation . . . . . . . . 207
Claudia D. Vargas and Angela Sirigu
20 Functional EEG Assessment of Face Transplantation . . . . . . . . . . . . 213
Vlodek Siemionow
21 Assessment Methods of Sensory Recovery
after Face Transplantation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Grzegorz Brzezicki and Maria Z. Siemionow
22 Methods of Assessment of Cortical Plasticity in Patients
Following Amputation, Replantation, and Composite
Tissue Allograft Transplantation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Amanda Mendiola and Maria Z. Siemionow
Part IV Approval Process of Face Transplantation
23 The Institutional Review Board Approval Process. . . . . . . . . . . . . . . 245
Chad R. Gordon and Maria Z. Siemionow
24 Informed Consent for Facial Transplantation. . . . . . . . . . . . . . . . . . . 255
Katrina A. Bramstedt
Contents xiii
25 Legal and Regulatory Aspects of Face
Donation and Transplantation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Alexandra K. Glazier
26 The Issue of Death and End of Life. . . . . . . . . . . . . . . . . . . . . . . . . . . . 267
Krzysztof Kusza, Jacek B. Cywinski, and Marc J. Popovich
27 Organ Procurement Organization Approval Process:
OPO Requirements for CTA Retrieval. . . . . . . . . . . . . . . . . . . . . . . . . 277
Gordon R. Bowen, Charles Heald, and Daniel J. Lebovitz
Part V Societal, Financial, and Public Relations
Issues in Face Transplantation
28 Addressing Religious and Cultural Differences
in Views on Face Transplantation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Antonio Rampazzo, Bahar Bassiri Gharb, and Maria Z. Siemionow
29 Comparative Cost Analysis of Conventional Reconstructions
and the First US Face Transplantation. . . . . . . . . . . . . . . . . . . . . . . . . 297
James R. Gatherwright, Frank Papay, Risal Djohan,
Elliott H. Rose, Lawrence J. Gottlieb, and Maria Z. Siemionow
30 Media-Related Aspects From a Public Relations Perspective . . . . . . 305
Eileen M. Sheil, Angie Kiska, and Tracy Wheeler
Part VI World Experience with Face Transplantation
31 Clinical Facial Composite Tissue Allotransplantation:
A Review of the Global Experience and Future Implications . . . . . . 315
Helen G. Hui-Chou and Eduardo D. Rodriguez
32 Facial Allotransplantation in China. . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Robert F. Lohman
33 The Cleveland Clinic Experience With the First
US Face Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
Maria Z. Siemionow, Risal Djohan, Steven Bernard, and Frank Papay
34 The Spanish Experience With Face Transplantation . . . . . . . . . . . . . 351
Pedro C. Cavadas, Luis Landin, Javier Ibañez, Alessandro Thione,
Jose Rodrigo, Federico Castro, Marino Blanes, and Jose Maria Zarzalejos
Andes
35 Microsurgical Aspects of Face Transplantation. . . . . . . . . . . . . . . . . . 363
Steven Bernard
36 The Sensory Recovery in Face Transplantation. . . . . . . . . . . . . . . . . . 375
Bahar Bassiri Gharb, Antonio Rampazzo, and Maria Z. Siemionow
xiv Contents
37 Infectious Issues in Face Transplantation. . . . . . . . . . . . . . . . . . . . . . . 389
Robin Avery, Chad R. Gordon, and Maria Z. Siemionow
Part VII Future Directions in Face Transplantation
38 The Military Relevance of Face Composite Tissue
Allotransplantation and Regenerative Medicine Research. . . . . . . . . 401
Robert G. Hale
39 International Registry of Face Transplantation. . . . . . . . . . . . . . . . . . 411
Palmina Petruzzo, Marco Lanzetta, and Jean Michel Dubernard
40 Concomitant Face and Upper Extremity Transplantation. . . . . . . . . 417
Chad R. Gordon, Fatih Zor, and Maria Z. Siemionow
41 Immunosuppression in Composite Tissue Allotransplantation. . . . . 427
Bijan Eghtesad and John J. Fung
42 Cellular Therapies in Face Transplantation. . . . . . . . . . . . . . . . . . . . . 439
Maria Z. Siemionow, Maria Madajka, and Joanna Cwykiel
43 Tissue Engineering for Facial Reconstruction. . . . . . . . . . . . . . . . . . . 447
Tsung-Lin Yang, James J. Yoo, Maria Z. Siemionow,
and Anthony Atala
Part VIII Current Status of Face Transplantation
44 An Update on Face Transplants Performed
Between 2005 and 2010. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 465
Maria Z. Siemionow, Can Ozturk, and Selman Altuntas
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48