The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes. This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.
Contents
Contributors. Foreword. 1 Insulin action and beta-cell function: role in metabolic regulation (Kristina M. Utzschneider and Steven E. Kahn). 2 Lipid and lipoprotein metabolism, and risk for cardiovascular disease (Frank M. Sacks). 3 Tobacco and risk for cardiovascular disease (C. Barr Taylor and Mickey Trockel). 4 Nutrition and risk for cardiovascular disease (Alice H. Lichtenstein). 5 Physical activity and cardiovascular health (William E. Kraus and William L. Haskell). 6 The obesity epidemic and cardiovascular risk (Paul Poirier). 7 Insulin resistance, the metabolic syndrome, and cardiovascular risk (Stanley S. Wang and Sidney C. Smith, Jr). 8 Diabetes mellitus and cardiovascular risk (Peter W. F. Wilson). 9 Lipid management and cardiovascular risk reduction (Antonio M. Gotto, Jr. and John A. Farmer). 10 Obesity management and cardiovascular risk reduction (George A. Bray). 11 Diabetes management and cardiovascular risk reduction (Jay S. Skyler). 12 A healthy lifestyle and cardiovascular risk reduction (Arne V. Astrup). Index. Author Disclosure Table