This book describes the current state of the art of the neurobiology of eating disorders and provides the latest insights and ideas in the eating disorders field. Important breakthroughs improved our understanding of the etiology of eating disorders. Due to neuropsychological studies we understand better which alterations underlie disturbed cognitive processing in anorexia nervosa and combined with imaging and genetics help to understand the underlying neural circuitry and genetic pathways. A new concept arises that anorexia nervosa is a neurodevelopmental striatocortical disorder. Perhaps the most important aspect of new insights into how symptoms are coded in the brain is that this provides new targets for developing more effective therapies. Because of the critical need to advance treatment, several chapters from pioneers in this field have been included . In summary, based upon the knowledge described in this book the editors hope that people in the eating disorder field get inspired to explore new horizons for therapeutic interventions that are based upon the new insights.

Part I Cognition and Emotions in Eating Disorders
Personality and Temperament . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Lisa Rachelle Riso Lilenfeld
Cognitions and Emotions in Eating Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Nicolette Siep, Anita Jansen, Remco Havermans, and Anne Roefs
Part II Neural Circuits, Neurotransmitters, and Behavior
Neurocircuity of Eating Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Walter H. Kaye, Angela Wagner, Julie L. Fudge, and Martin Paulus
Serotonin: Imaging Findings in Eating Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Ursula F. Bailer and Walter H. Kaye
Dopamine-Based Reward Circuitry Responsivity, Genetics,
and Overeating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Eric Stice, Sonja Yokum, David Zald, and Alain Dagher
Reward and Neurocomputational Processes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
Guido K.W. Frank
Cognitive-Behavioral Flexibility in Anorexia Nervosa . . . . . . . . . . . . . . . . . . . . . 111
Hans-Christoph Friederich and Wolfgang Herzog
Neural Circuits, Neurotransmitters, and Behavior . . . . . . . . . . . . . . . . . . . . . . . . 125
Howard Steiger, Kenneth R. Bruce, and Patricia Groleau
vii
Part III Genetics, Gender and Heritability
The Heritability of Eating Disorders: Methods and Current Findings . . 141
Laura M. Thornton, Suzanne E. Mazzeo, and Cynthia M. Bulik
The Genetics of Eating Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Sietske G. Helder and David A. Collier
The Influence of Gender and Puberty on the Heritability
of Disordered Eating Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Kristen M. Culbert, Sarah E. Racine, and Kelly L. Klump
Part IV Neuroendocrinology and Animal Research
New Frontiers in Endocrinology of Eating Disorders . . . . . . . . . . . . . . . . . . . . . . 189
Palmiero Monteleone
Animal Models of Eating Disorder Traits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Martien J.H. Kas and Roger A.H. Adan
Neurobiology Driving Hyperactivity in Activity-Based Anorexia . . . . . . . . . 229
R.A.H. Adan, J.J.G. Hillebrand, U.N. Danner, S. Cardona Cano,
M.J.H. Kas, and L.A.W. Verhagen
Part V Translational Approach to Treatment
Translating Experimental Neuroscience into Treatment of Eating
Disorders: Two Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
Ulrike Schmidt, Anna Oldershaw, and Annemarie van Elburg
Cognitive Remediation Therapy for Eating Disorders: Development,
Refinement and Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Kate Tchanturia and James Lock
Incorporating Dispositional Traits into the Treatment
of Anorexia Nervosa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
Nancy L. Zucker, David Herzog, Ashley Moskovich, Rhonda Merwin,
and Tammy Lin
Index