Part I Introduction and History of Probiotics ........................................... 1
1 Probiotics: From the Ancient Wisdom to the Actual
Therapeutical and Nutraceutical Perspective ........................................ 3
Giuseppe Caramia and Stefania Silvi
Part II The Gut Microorganisms and Probiotics ...................................... 39
2 The Intestinal Microbiota and Probiotics ............................................... 41
Sofia D. Forssten, Sampo J. Lahtinen and Arthur C. Ouwehand
3 Ecology of Probiotics and Enteric Protection ......................................... 65
Melanie Gagnon, Annina Zihler, Christophe Chassard
and Christophe Lacroix
Part III Pathophysiology of Enteric Disorders Due to
Disturbed Microbiota .................................................................... 87
4 Factors Causing Disturbances of the Gut Microbiota ........................... 89
Joshua J. Malago and Jos F. J. G. Koninkx
5 The Gut Microbiota, Probiotics and Infectious Disease ........................ 113
Cormac G. M. Gahan, Gerald C. O fSullivan and J. Kevin Collins
Part IV Application of Molecular Biology and -omics of Probiotics
in Enteric Protection ...................................................................... 131
6 Application of Molecular Biology and Genomics of
Probiotics for Enteric Cytoprotection ..................................................... 133
Saloomeh Moslehi-Jenabian, Dennis Sandris Nielsen and Lene Jespersen
7 Application of Probiotic Proteomics in Enteric Cytoprotection ........... 155
Hans Christian Beck, Soren Feddersen and Jorgen Petersen
vi
8 Promoting Gut Health with Probiotic Metabolomics ........................ 169
Sebastiano Collino, Francois-Pierre J. Martin, Sunil Kochhar
and Serge Rezzi
Part V Probiotics, Gut Immunology and Enteric Protection ................. 187
9 Microbiota, Probiotics and Natural Immunity of the Gut ................ 189
Eduardo Jorge Schiffrin and Anne Donnet-Hughes
10 Interaction of Probiotics with the Acquired Immune System
in the Gut ............................................................................................... 207
Rossana D fArienzo, Kathryne B. Schwartz and Mauro Rossi
11 The Protective Role of Probiotics in Disturbed Enteric Microbiota ... 221
Denis Roy and Veronique Delcenserie
12 Modulation of Immune System by Probiotics to Protect
Against Enteric Disorders .................................................................... 263
Joshua J. Malago and Jos F. J. G. Koninkx
Part VI Probiotics for Enteric Therapy ................................................... 287
13 Probiotic-Pathogen Interactions and Enteric Cytoprotection .......... 289
Joshua J. Malago and Jos F. J. G. Koninkx
14 Bacteriocins of Probiotics and Enteric Cytoprotection ..................... 313
Bojana Bogovi.-Matija.i. and Irena Rogelj
15 Probiotics in Clinical Practice as Therapeutics Against
Enteric Disorders .................................................................................. 355
Ouafae Karimi and A. S. Pena
16 Potential Mechanisms of Enteric Cytoprotection by
Probiotics: Lessons from Cultured Human Intestinal Cells ............. 375
Vanessa Lievin-Le Moal and Alain L. Servin
17 Probiotics and Enteric Cancers ........................................................... 399
Min-Tze Liong, Huey-Shi Lye, Siok-Koon Yeo, Joo-Ann Ewe,
Lay-Gaik Ooi and Ting-Jin Lim
Part VII The Future of Probiotics ............................................................ 427
18 Designer Probiotics and Enteric Cytoprotection ............................... 429
Adrienne W. Paton, Renato Morona and James C. Paton
19 Future Prospects of Probiotics as Therapeutics Against
Enteric Disorders .................................................................................. 445
E. P. Culligan, C. Hill and R. D. Sleator
Index