Vol. 711

The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results. Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.

Table of contents Part I: Introduction 1. From Molecules to Man: The Dawn of a Vitreous Man Michel Modo and Jeff W.M. Bulte Part II: General Techniques 2. Magnetic Resonance Safety Andy Simmons and Kristina Hakansson 3. Measuring the Absolute Water Content Of the Brain Using Quantitative MRI Nadim Joni Shah, Veronika Ermer, and Ana-Maria Oros-Peusquens 4. Magnetic Resonance Relaxation and Quantitative Measurement in the Brain Sean C.L. Deoni 5. Magnetic Resonance Brain Image Processing and Arithmetic with FSL William R. Crum 6. Diffusion Tensor Imaging Derek K. Jones and Alexander Leemans 7. Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Cynthia A. Massaad and Robia G. Pautler 8. Sodium MRI Ronald Ouwerkerk 9. MR Spectroscopy and Spectroscopic Imaging of the Brain He Zhu and Peter B. Barker 10. Amide Proton Transfer Imaging of the Human Brain Jinyuan Zhou 11. High Field MRI of Brain Iron Jozef H. Duyn 12. Magnetic Resonance Imaging-Based Mouse Brain Atlas and Its Applications Manisha Aggarwal, Jiangyang Zhang, and Susumu Mori 13. CEST MRI Reporter Genes Guanshu Liu, Jeff W.M. Bulte, and Assaf A. Gilad 14. Longitudinal Functional Magnetic Resonance Imaging in Animal Models Afonso C. Silva, Junjie V. Liu, Yoshiyuki Hirano, Renata F. Leoni, Hellmut Merkle, Julie B. Mackel, Xian Feng Zhang, George C. Nascimento, and Bojana Stefanovic 15. Combining EEG and fMRI Karen Mullinger and Richard Bowtell 16. MR Angiography and Arterial Spin Labeling David Thomas and Jack Wells Part III: Specific Applications 17. MRI Phenotyping of Genetically Altered Mice Jason P. Lerch, John G. Sled, and R. Mark Henkelman 18. Gene Targeting MRI: Nucleic Acid-Based Imaging and Applications Philip K. Liu and Christina H. Liu 19. Molecular MRI Approaches to the Detection of CNS Inflammation Nicola R. Sibson, Daniel C. Anthony, Sander van Kasteren, Alex Dickens, Francisco Perez-Balderas, Martina A. McAteer, Robin P. Choudhury, and Benjamin G. Davis 20. Brain Redox Imaging Ken-ichiro Matsumoto, Fuminori Hyodo, Kazunori Anzai, Hideo Utsumi, James B. Mitchell, and Murali C. Krishna 21. Systems Biology Approach to Imaging of Neural Stem Cells LiHua Ma, Yao Li, Petar M. Djuric, and Mirjana Maletic-Savatic 22. MRI of Transplanted Neural Stem Cells Stacey M. Cromer Berman, Piotr Walczak, and Jeff W.M. Bulte 23. MRI of Experimental Gliomas Frits Thorsen 24. MRI in Experimental Stroke Timothy Q. Duong 25. Non-Invasive MR Imaging of Neurodegeneration in a Rodent Model of Parkinson's Disease Anthony C. Vernon and Michel Modo 26. Detecting Amyloid-beta Plaques in Alzheimer's Disease Christof Baltes, Felicitas Princz-Kranza, Markus Rudina, and Thomas Mueggler 27. Assessing Subtle Structural Changes in Alzheimer's Disease Patients Jennifer L. Whitwell and Prashanthi Vemuri 28. Pharmacological Application of fMRI Mitul A. Mehta and Owen G. O'Daly 29. MRI of Neuronal Plasticity in Rodent Models Galit Pelled 30. MR-Guided Focused Ultrasound for Brain Ablation and Blood-Brain Barrier Disruption Yuexi Huang and Kullervo Hynynen