Oxygen-Ozone therapy is a complementary approach less known than homeopathy and acupuncture because it has come of age only three decades ago. This book clarifies that, in the often nebulous field of natural medicine, the biological bases of ozone therapy are totally in line with classical biochemistry, physiological and pharmacological knowledge. Ozone is an oxidizing molecule, a sort of super active oxygen, which, by reacting with blood components generates a number of chemical messengers responsible for activating crucial biological functions such as oxygen delivery, immune activation, release of hormones and induction of antioxidant enzymes, which is an exceptional property for correcting the chronic oxidative stress present in atherosclerosis, diabetes and cancer. Moreover, by inducing nitric oxide synthase, ozone therapy may mobilize endogenous stem cells, which will promote regeneration of ischemic tissues. The description of these phenomena offers the first comprehensive picture for understanding how ozone works and why. When properly used as a real drug within therapeutic range, ozone therapy does not only does not procure adverse effects but yields a feeling of wellness. Half the book describes the value of ozone treatment in several diseases, particularly cutanious infection and vascular diseases where ozone really behaves as a wonder drug . The book has been written for clinical researchers, physicians and ozone therapists, but also for the layman or the patient interested in this therapy

Table of contents INTRODUCTION CHAPTER 1 PHYSICAL-CHEMICAL PROPERTIES OF OZONE. NATURAL PRODUCTION OF OZONE. THE TOXICOLOGY OF OZONE CHAPTER 2 HOW OZONE IS GENERATED AND ITS CONCENTRATIONS MEASURED? CHAPTER 3 PREPARATION OF OZONATED WATER AND OIL FOR THE TOPICAL THERAPY. OZONE AS A DRINKING WATER DISINFECTANT. OZONE DISINFECTION TO PREVENT NOSOCOMIAL INFECTIONS CHAPTER 4 HOW DOES OZONE ACT? HOW AND WHY CAN WE AVOID OZONE TOXICITY? CHAPTER 5 HOW IS OZONE ADMINISTERED? CHAPTER 6 THE ACTUAL SIX THERAPEUTIC MODALITIES 1. Major ozone autohaemotherapy (AHT) 2. Minor ozone autohaemotherapy 3. The biooxidative therapy with hydrogen peroxide dissolved in the glucose solution. The continuous search of an efficacious blood's substitute. 4. Rectal insufflation of oxygen-ozone (RI) 5. Quasi-total body exposure to oxygen-ozone (BOEX) 6. Extracorporeal blood circulation against oxygen-ozone (EBOO) CHAPTER 7 THE POTENTIAL TOXICITY OF OZONE. SIDE EFFECTS AND CONTRAINDICATIONS OF OZONE THERAPY CHAPTER 8 IS OZONE REALLY A WONDER DRUG ? CHAPTER 9 THE CLINICAL APPLICATION OF OZONE THERAPY 1. Infectious diseases (bacterial, viral, fungal, parasitic) 1.1 Viral infections 1.1.1 HIV-1 infection 1.1.2 Chronic Hepatitis B and C 1.1.3 Herpetic infections and Herpes Zoster 1.1.4 Papillomavirus Infections (HPV) 1.1.5 The common cold 2. Ischaemic diseases (hind-limb ischaemia, cerebral and heart ischaemia, venous stasis) 3. Retinal degenerative disorders 4. Neurodegenerative diseases 5. Autoimmune diseases. Can ozone-therapy do better than antibodies to TNF alpha? 6. Ozone therapy in cancer 7. The dysmetabolic syndrome and ozonetherapy 8. Is any haematological disease treatable with ozone therapy? 9. Can ozone therapy slow down the progression of oxidative stress in renal diseases and haemodialysis? 10. Dermatological diseases and ozone therapy 11. Ozone therapy in pulmonary diseases 12. The problems of tinnitus and sudden hearing loss (SHL). Is ozone therapy of any help? 13. The paradoxical effect of ozone in orthopaedic diseases. The problem of back- ache 14. A therapeutic option for chronic fatigue syndrome (CFS) and fibromyalgia 15. Ozone therapy in emergency situations, before transplantation and elective surgery 16. Ozonetherapy in dentistry and stomatology 17. Ozonetherapy in cosmetology 18 May ozone represent the elixir of life? CHAPTER 10 THE DILEMMA BETWEEN HYPERBARIC OXYGEN THERAPY (HOT) AND OZONE THERAPY CHAPTER 11 THE PROMISING FUTURE OF OZONE THERAPY IN MEDICINE