Ocular Disease-a newly introduced companion volume to the classic Adler's Physiology of the Eye-correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert-two of the world's leading ophthalmic clinician-scientists-have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalmology: retina, cornea, cataract, glaucoma, uveitis, and more. The concise chapter structure features liberal use of color-with 330 full-color line artworks, call-out boxes, summaries, and schematics for easy navigation and understanding. In print and online at expertconsult.com, this comprehensive resource provides you with a better and more practical understanding of the science behind eye disease and its relation to treatment.

Table of Contents

SECTION 1 Cornea


1. Loss of corneal transparency

Russell L McCally


2. Abnormalities of corneal wound healing

Audrey M Bernstein


3. Wound healing after laser in situ keratomileusis and photorefractive keratectomy

Fabricio Witzel de Medeiros and Steven E Wilson


4. Genetics and mechanisms of hereditary corneal dystrophies

John D Gottsch


5. Fuchs' endothelial corneal dystrophy

Vinay Gutti, David S Bardenstein, Sudha Iyengar, and Jonathan H Lass


6. Keratoconus

M Cristina Kenney and Ronald N Gaster


7. Infectious keratitis

Michael S Gilmore, Susan R Heimer, and Ai Yamada


8. Corneal graft rejection

Daniel R Saban, Mohammad H Dastjerdi, and Reza Dana


9. Corneal edema

Daniel G Dawson and Henry F Edelhauser


10. Corneal angiogenesis and lymphangiogenesis

Chih-Wei Wu, David Ellenberg, and Jin-Hong Chang


11. Ocular surface restoration

Julie T Daniels, Genevieve A Secker, and Alex J Shortt


12. Herpetic keratitis

Pranita P Sarangi and Barry T Rouse


13. Ocular allergy

Neal P Barney, Ellen B Cook, James L Stahl, and Frank M Graziano




SECTION 2 Dry eye


14. The lacrimal gland and dry-eye disease

Darlene A Dartt


15. Immune mechanisms of dry-eye disease

Austin K Mircheff and Joel E Schechter


16. Disruption of tear film and blink dynamics

Jianhua Wang and Anuj Chauhan


17. Abnormalities of eyelid and tear film lipid

Gary N Foulks and Douglas Borchman


18 Dry eye: abnormalities of tear film mucins

Ann-Christin Albertsmeyer and Ilene K Gipson




SECTION 3 Glaucoma

19. Steroid-induced glaucoma

Abbot F Clark, Xinyu Zhang, and Thomas Yorio


20. Biomechanical changes of the optic disc

Ian A Sigal, Michael D Roberts, Michael JA Girard, Claude F Burgoyne, and J Crawford Downs


21. Pigmentary dispersion syndrome and glaucoma

Michael G Anderson


22. Abnormal trabecular meshwork outflow

Paul A Knepper and Beatrice YJT Yue


23. Pressure-induced optic nerve damage

James C Tsai


24. Exfoliation (pseudoexfoliation) syndrome

Robert Ritch and Ursula Schlötzer-Schrehardt


25. Angle closure glaucoma

Shamira Perera, Nishani Amerasinghe, and Tin Aung


26. Central nervous system changes in glaucoma

Yeni N Yücel and Neeru Gupta


27. Retinal ganglion cell death in glaucoma

Heather R Pelzel and Robert W Nickells


28. Wound-healing responses to glaucoma surgery

Stelios Georgoulas, Annegret Dahlmann-Noor, Stephen Brocchini, and Peng Tee Khaw


29. Blood flowchanges in glaucoma

Leopold Schmetterer and Mark Lesk




SECTION 4 Lens


30. Biochemical mechanisms of age-related cataract

David C Beebe, Ying-Bo Shui, and Nancy M Holekamp


31. Posterior capsule opacification

Judith West-Mays and Heather Sheardown


32. Diabetes-associated cataracts

Peter F Kador


33. Steroid-induced cataract

Abbas Samadi


34. Presbyopia

Jane F Koretz


35. Restoration of accommodation

Stephen D McLeod and Michelle Trager Cabrera


36. Intraoperative floppy iris syndrome

Amy Lin and Roger F Steinert




SECTION 5 Neuro-ophthalmology


37. Optic neuritis

John R Guy and Xiaoping Qi


38. Abnormal ocular motor control

James A Sharpe and Arun Sundaram


39. Idiopathic intracranial hypertension (idiopathic pseudotumor cerebri)

Deborah M Grzybowski and Martin Lubow


40. Giant cell arteritis

Lynn K Gordon


41. Ischemic optic neuropathy

Helen Danesh-Meyer


42. Optic nerve axonal injury

Daniela Toffoli and Leonard A Levin


43. Leber's hereditary optic neuropathy

Alfredo Sadun and Alice Kim


44. Optic atrophy

Nathan T Tagg and Randy H Kardon


45. Nystagmus

Frank Proudlock and Irene Gottlob


46. Toxic optic nerve neuropathies

FT ";Fritz"; Fraunfelder and FW ";Rick"; Fraunfelder




SECTION 6 Oncology

47. Uveal melanoma

Zélia MS Corrêa and J William Harbour


48. Genetics of hereditary retinoblastoma

Alejandra G de Alba Campomanes and Joan M O'Brien


49. Molecular basis of low-penetrance retinoblastoma

Katie Matatall and J William Harbour


50. Vasculogenic mimicry

Robert Folberg and Andrew J Maniotis


51. Treatment of choroidal melanoma

Aimee V Chappelow and Andrew P Schachat


52. Sebaceous cell carcinoma

Alon Kahana, Jonathan T Pribila, Christine C Nelson, and Victor M Elner


53. Neurofibromatosis

Robert Listernick and David H Gutmann




SECTION 7 Other


54 Phthisis bulbi

Ingo Schmack, Hans E Völcker, and Hans E Grossniklaus


55. Myopia

Terri L Young


56. Pathogenesis of Graves' ophthalmopathy

A Reagan Schiefer and Rebecca S Bahn




SECTION 8 Pediatrics


57. Duane syndrome

Joseph L Demer


58. Amblyopia

Robert F Hess and Nigel Daw


59 Strabismus

Christopher S von Bartheld, Scott A Croes, and L Alan Johnson


60. Albinism

Gerald F Cox and Anne B Fulton


61. Aniridia

Elias I Traboulsi




SECTION 9 Retina


62. Color vision defects

Maureen Neitz and Jay Neitz


63. Acute retinal vascular occlusive disorders

Sohan Singh Hayreh


64. Retinal photic injury: laboratory and clinical findings

Daniel Organisciak and Marco Zarbin


65. Vascular damage in diabetic retinopathy

Timothy S Kern and Suber Huang


66. Neovascularization in diabetic retinopathy

Corey B Westerfeld and Joan W Miller


67. Diabetic macular edema

Pascale Massin, Michel Paques, and Jean-Antoine Pournaras


68. Dry age-related macular degeneration and age-related macular degeneration pathogenesis

Marco Zarbin and Janet S Sunness


69. Neovascular age-related macular degenerationDavid E Lederer, Scott W Cousins, and Karl G Csaky


70. Inhibition of

Anthony P Adamis and Adrienne Berman


71. Retinal detachment

Steven K Fisher and Geoffrey P Lewis


72. Retinopathy of prematurity

Mary Elizabeth Hartnett and Cynthia A Toth


73. Retinal energy metabolism

Robert A Linsenmeier


74. Retinitis pigmentosa and related disorders

Eric A Pierce


75 Visual prostheses and other assistive devices

Muhammad Ali Memon and Joseph F Rizzo III


76. Paraneoplastic retinal degeneration

Grazyna Adamus


77. Cellular repopulation of the retina

Budd AL Tucker, Michael J Young, and Henry J Klassen


78. Proliferative vitreoretinopathy

Clyde Guidry




SECTION 10 Uveitis


79. Immunologic mechanisms of uveitis

Steven Yeh, Zhuqing Li, and Robert B Nussenblatt


80. Herpesvirus retinitis

Sally S Atherton and Mei Zheng


81. Sympathetic ophthalmia

Mirunalini Kumaradas and Narsing A Rao


82. Scleritis

Srilakshmi M Sharma and James T Rosenbaum


83 Infectious uveitis

Pooja Bhat, Allen Tony Jackson, and C Stephen Foster


84. Ocular sarcoidosis

Russell N Van Gelder and Suzanne M Dintzis