Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.

Contents
Foreword G. Comi; 1. Multiple sclerosis: diagnosis and definitions; 2. Depression: prevalence, symptoms, diagnosis and clinical correlates; 3. Depression: aetiology and treatment; 4. Multiple sclerosis, bipolar affective disorder and euphoria; 5. Multiple sclerosis and pseudobulbar affect; 6. Multiple sclerosis and psychosis; 7. Cognitive impairment in multiple sclerosis; 8. The natural history of cognitive change in multiple sclerosis; 9. Cognitive impairment in multiple sclerosis: detection, management and significance; 10. Neuroimaging correlates of cognitive dysfunction; 11. Multiple sclerosis, disease modifying treatment and behavioral change; 12. Multiple sclerosis: a subcortical, white matter dementia?

Reviews
'This is a clinically oriented volume, which is well researched, written and edited Feinstein should be congratulated for his effort in reviewing and bringing together what is known of the psychiatry of MS ' British Journal of Psychiatry

'It will be useful for anyone involved in the management of patients with multiple sclerosis.' Journal of Neurology, Neurosurgery and Psychiatry

'This readable book is both a comprehensive overview, to be read cover-to-cover, and a reference volume, to be consulted as appropriate Feinstein deserves particular commendation for his strong pragmatic and clinical bias All in all, I recommend this book to complement any MS library.' The International MS Journal

' this updated version of the original text is both a comprehensive overview and a practical reference volume to be consulted readily and regularly. Dr Feinstein succeeds in educating the reader why neuropsychiatric disorders assume a key role in the management of MS. I recommend this book to complement the library of not only neurologists and psychiatrists, but to anyone involved in the care of persons with MS. This text can serve as a dependable guide to assist in the recognition and treatment of neuropsychiatric disorders associated with MS that have such an impact in this population's quality of life.' Archives of Neurology