Description
Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.

Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Contents

Section I. Basis of Disease Pathogenesis

1. Genetics
MHC Class II (J. Reveille, University of Texas at Houston)
MHC Class III, Complement(J. Atkinson, Washington University)
Constitutive Genes and Lupus (J. Harley, University of Oklahoma Health Sciences Center)
Murine Models of SLE and Genetics (A. Theofilopoulos, Scripps Research Institute)

2. Cellular Pathogenesis
Dendritic Cells, Antigen Presenting Cells (M Mamula, Yale University School of Medicine)
T Cells and SLE (TH 17, TH2, and T-regulatory Cells) (JC Crispin, Mexico)
B Cells and SLE (M Doerner, Charity Hospital, Germany)
Role of polymorphonuclear leukocytes (B. Cronstein, New York School of Medicine)
Apoptosis (P. Cohen, University of Penn)
Mitochondrial Damage (Perl, State University of New York)
Nitric Oxide (G. Gilkenson)

3. Humoral Pathogenesis
Origins of autoantibodies (W. Reeves, University of Florida)
Anti DNA (B . Diamond, Albert Einstein College of Medicine, NY)
Anti Cytoplasmic Antibody (M. Reichlin, Oklahoma University Health Center)
Antihistone, splicesomal Antibody (R. Rubin, University of New Mexico)
Cytokines (P. Crow)
Interferon alpha and SLE (V. Pascual, Baylor Institute for Immunological Research, Texas)
Immune Complexes (M. Wener, University of Washington)

4. Environmental Aspects of Pathogenesis
Drug Induced Lupus Basic Science (B. Richardson, University of Michigan)
Sex Hormones and Age (R. Lahita)
Infections and Lupus TBD
Tolerance and Autoimmunity TBD
Non Murine, Non Human SLE: Dogs, Horses (R. Halliwell, University of Edinburgh)

Section II. Clinical Aspects of Disease

1. The Clinical Presentation
SLE in the Adult (R. Lahita)
SLE in the Neonate (J. Buyon, Hospital for Joint Diseases, NY)
Childhood Disease (I. Szer, Children's Hospital of San Diego)
Drug Induced Disease (B.A. Mongey, University of Cincinnati)
Use of Laboratory in Diagnosis (P. Schur, Brigham and Women's Hospital, Boston)
Pregnancy (C. Laskin, University of Toronto)
Epidemiology of SLE (D. Gladman, Toronto Western Hospital)
Overlap Syndromes: Sjogren and MCTD (R. Hoffman, University of Miami)
Fibromyalgia and SLE (J. Winfield, University of North Carolina)
Imaging of SLE (L. Shapeero, US Military Cancer Institute, Bethesda)
Monitoring Disease Activity (M. Liang, Brigham and Women's Hospital, Boston)

2. Organ Systems
CNS / Encephalopathy, Peripheral Nerve Disease (R. Brey, University of Texas Health Center)
Cognitive Dysfunction (J. Denburg, McMaster University, Hamilton, Canada)
Psychiatric Aspects of SLE (J. Levenson, Virginia Commonwealth University)
Skin (C. Nousari, Cleveland Clinic Florida)
Kidney (J. Balow, NIH, Bethesda)
Heart (S. Manzi, University of Pittsburgh)
Vasculitis (G. Hoffman, Cleveland Clinic Foundation)
The Lung (E. Clinton Lawrence, Emory University)
Gastrointestinal: Hepatic (I. Mackay, Monash University, Australia)
Gastrointestinal: Non Hepatic (L. Mayer, Mount Sinai Medical Center, NY)
Cellular Hematology: Anemia, thrombocytopenia, Leucopenia (R. Nachman, NY Hospital Cornell Medical Center)
Musculoskeletal System: articular disease, Bone Metabolism (J. Zuckerman, Hospital for Joint Disease, NY)
Eye and Ear and SLE (TBD)

Section III. APLS (Antiphospholipid Syndrome)

1. Pathogenesis
Antiphospholipid Antibody: Pathogenesis (T. Koike, Hokkaido University, Japan)
Endothelial Cell Damage and Atherosclerosis (J. Merrell)
Cofactors and Disease (S. Krilis)

2. Clinical
Laboratory Testing in APLS (TBD)
Clinical Presentation (M. Khamashta, St Thomas Hospital, London)
Pregnancy and APLS. (L. Sammaritano, Weill-Cornell Medical College, NY)

Section IV. Treatment of SLE

Non Steroidal agents (TBD)
Steroids (TBD)
Antimalarials (TBD)
Cytotoxic Agents (TBD)
Biological Agents (TBD)
Non-Pharmacological Therapies in SLE (TBD)