Updates the first edition and includes completely new chapters
Represents a unique and unparalleled source of information on the many different safety issues relating to the diverse contrast media
Includes chapters on acute and delayed non-renal adverse reactions and on renal adverse reactions
Includes the ESUR guidelines on contrast media
Presented in a handy, easy-to-use format
In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues.


Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media

Section I General Issues


1 Classification and Terminology

Peter Aspelin, Marie-France Bellin, Jarl . Jakobsen, and Judith A. W. Webb


2 Requests for Imaging Using Contrast Agents What Information Must be Provided

Samed K. Morcos and Marie-France Bellin


3 Off-Label Use of Medicines Legal Aspects

June M. Raine


4 Pharmacovigilance When to Report Adverse Reactions

Doris I. Stenver


5 What is Required in Order to Get the Authorities to Approve an New Contrast Agent

Doris I. Stenver


6 A Critical Review of Meta-Analysis of Adverse Events After Contrast Agents

Giuseppe Biondi Zoccai and Maria Lotrionte



Section II Iodinated and Gadolinium Contrast Media


A. General Adverse Reactions


7 Prevention of Acute Reactions

Judith A.W. Webb


8 Management of Acute Adverse Reactions

Henrik S. Thomsen


B. Renal Adverse Effects


9 Contrast Medium Induced Nephropathy

Henrik S. Thomsen


10 Dialysis and Contrast Media

Sameh K. Morcos


11 Non-Insulin Dependent Diabetes and Contrast Media

Judith A.W. Webb


C. Other Adverse Effects


12 Pregnancy and Lactation

Judith A. W. Webb


13 Phaechromocytoma

Judith A.W. Webb


14 Interactions with Other Drugs and Clinical Tests

Sameh K. Morcos


15 Extravasation Injury

Jarl . Jakobsen



Section III Iodinated Contrast Media


16 Late Adverse Reactions

Fulvio Stacul


17 Effects on the Blood and Endothelium

Peter Aspelin, Fulvio Stacul, and Sameh K. Morcos


18 Effect on Thyroid Function

Aart van der Molen


19 Pulmonary Effects

Sameh K. Morcos

Section IV MR Contrast Media


A. Non-Tissue Specific Extracellular MR Contrast Media


20 Chelates and Stability

Sameh K. Morcos


21 Diagnostic Efficacy

Aart van der Molen


22 Radiography with Gadolinium Contrast Agents

Henrik S. Thomsen

B. Gadolinium-Based Contrast Agents


23 Acute Adverse Reactions

Gertraud Heinz-Peer


24 Delayed Reactions: Nephrogenic Systemic Fibrosis (NSF)

Henrik S. Thomsen

C. Organ-Specific MR Contrast Agents


25 Gadolinium Based Contrast Agents

Marie-France Bellin


26 Non-Gadolinium Based Contrast Agents

Marie-France Bellin


Section V - Ultrasonographic Contrast Media


27 Safety of Ultrasonographic Agents

Raymond Oyen

Section VI Barium Preparations


28 Barium Preparations: Safety Issues

Sameh K. Morcos

Appendix


29 ESUR Guidelines on Contrast Media

Contrast Media Safety Committee


30 Official Publications from the Contrast Media Safety Committee of the

European Society of Urogenital Radiology

Contrast Media Safety Committee