Iatrogenic hypoglycemia, or low blood sugar caused by medical treatment or diagnostic procedures, is a challenge facing people with diabetes and their heath care providers. If not addressed, it can lead to significant complications. Dr. Cryer examines this persistent problem from a pathophysiological perspective. The chapters include: The Clinical Problem of Hypoglycemia in Diabetes; The Physiology of Glucose Counterregulation; The Pathophysiology of Glucose Counterregulation in Diabetes; Risk Factors for Hypoglycemia in Diabetes; Clinical Definition and Classification of Hypoglycemia in Diabetes; Prevention and Treatment of Hypoglycemia in Diabetes; and, Perspective on Hypoglycemia in Diabetes.