Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current.

Table of Contents
PART 1: Fundamental Principles of the Immune Response
1 The human immune response 2 Organization of the immune system 3 Innate immunity 4 Antigen receptor genes, gene products, and co-receptors 5 The major histocompatibility complex 6 Antigens and antigen processing 7 Antigen-presenting cells and antigen presentation 8 B-cell development and differentiation 9 T-cell development 10 Cytokines and cytokine receptors 11 Chemokines and chemokine receptors 12 Lymphocyte adhesion and trafficking 13 T-cell activation and tolerance 14 Programmed cell death in lymphocytes
PART 2: Host Defense Mechanisms and Inflammation
15 Immunoglobulin function 16 Regulatory T cells 17 Helper T-cell subsets and control of the inflammatory response 18 Cytotoxic lymphocyte function and natural killer cells 19 Host defenses at mucosal surfaces 20 Complement and complement deficiencies 21 Phagocytes and phagocyte deficiencies 22 Mast cells, basophils and mastocytosis 23 Eosinophils and eosinophilia
PART 3: Infection and Immunity
24 Immune response to extracellular bacteria 25 Immune responses to intracellular bacteria 26 Immune responses to spirochetes 27 Immune responses to viruses 28 I mmune responses to protozoans 29 Immune responses to helminths
PART 4: Immunologic Deficiencies
30 Evaluation of the immunodeficient patient 31 Infections in the immunocompromised host 32 Development of the fetal and neonatal immune system 33 Aging and the immune system 34 Primary antibody deficiencies 35 Primary T-cell immunodeficiencies 36 Inherited disorders of IFN-?-, IFN-a/ -, and NF-?B-mediated immunity 37 HIV infection and acquired immunodeficiency syndrome 38 Immunodeficiency due to congenital, metabolic, infectious, surgical, and environmental factors
PART 5: Allergic Diseases
39 Pathogenesis of asthma 40 Management of the asthmatic patient 41 Rhinitis and sinusitus 42 Urticaria, angiodema, and anaphylaxis 43 Allergic reactions to stinging and biting insects 44 Atopic and contact dermatitis 45 Food allergy 46 Eosinophil-associated gastrointestinal disorders (EGID ) 47 Allergic disorders of the eye 48 Drug hypersensitivity 49 Occupational and environmental allergic disorders
PART 6: Systemic Immune Diseases
50 Mechanisms of autoimmunity 51 S ystemic lupus erythematosus 52 Rheumatoid arthritis 53 Juvenile idiopathic arthritis 54 Sjögren's syndrome 55 Systemic sclerosis 56 Inflammatory muscle diseases 57 Spondyloarthritis 58 Small- and medium-vessel primary vasculitis 59 Large-vessel vasculitides 60 Autoinflammatory fever syndromes 61 Antiphospholipid syndrome
PART 7: Organ Specific Inflammatory Disease
62 Immunohematologic disorders 63 Bullous diseases of the skin and mucous membranes 64 Myasthenia gravis 65 Multiple sclerosis 66 Autoimmune peripheral neuropathies 67 Immunologic renal diseases 68 Inflammation and atherothrombosis 69 Autoimmune thyroid diseases 70 Diabetes and related autoimmune diseases 71 Immunologic lung diseases 72 Sarcoidosis 73 Immunologic ocular disease 74 Immunologic disease of the gastrointesinal tract 75 Inflammatory hepatobiliary cirrhosis
PART 8: Neoplasia and the Immune System
76 Lymphoid leukemias 77 Lymphomas including Hodgkin lymphoma 78 Monoclonal gammopathies 79 Tumor immunology and immunotherapy
PART 9: Transplantation
80 Concepts and challenges in transplantation: rejection, immunosuppression and tolerance 81 Challenges and potentials of xenotransplantation 82 Hematopoietic stem cell transplantation for malignant diseases 83 Stem cell transplantation and immune reconstitution in immunodeficiency 84 Thymic reconstitution
PART 10: Prevention and Therapy of Immunologic Diseases
85 Immunoglobulin therapy: replacement and immunomodulation 86 Gene transfer therapy of immunologic diseases 87 Glucocorticoids 88 Nonsteroidal anti-inflammatory drugs 89 Antihistamines 90 Immunomodulating pharmaceuticals 91 Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders 92 Vaccines 93 Immunotherapy of allergic disease 94 Cytokine therapy 95 Monoclonal antibodies and fusion proteins
PART 11: Diagnostic Immunology
96 Assessment of proteins of the immune system 97 Flow cytometry 98 Assessment of functional immune responses 99 Assessment of neutrophil function 100 Assessment of human allergic diseases 101 Molecular methods
Apendices
1 Selected CD molecules and their characteristics 2 Laboratory reference values 3 Chemokines 4 Cytokines