Part I of a two-volume set in the Handbook of Clinical Neurology series on Parkinson's Disease and related disorders.

Features

Part I of a two volume set on Parkinson's Disease in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
International list of contributors including the leading workers in the field.
Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of Parkinson's Disease and on patient care.

Contents
Section 1 Scientific foundation
1. Anatomy and physiology of the basal ganglia: relevance to parkinson's disease and related disorders, Thomas Wichmann and Mahlon R. DeLong (Atlanta, GA, USA)
2. Functional neurochemistry of the basal ganglia, Parshia Samadi, Claude Rouillard, Paul J. Bédard and Thérèse Di Paolo (Québec, Canada)
3. Neurophysiology of basal ganglia diseases, Alfredo Berardelli (Rome, Italy)
4. Dopamine receptor pharmacology, Richard B. Mailman and Xuemei Huang (Chapel Hill, NC, USA)
Section 2 General aspects of Parkinson's disease
5. History of Parkinson's disease, Jennifer G. Goldman and Christopher G. Goetz (Chicago, IL,)
6. Epidemiology of Parkinson's disease, Meike Kasten, Annabel Chade and Carolyn M. Tanner (Sunnyvale, CA, USA)
7. Neurochemistry of the basal ganglia in Parkinson's disease, Jayaraman Rao (New Orleans, LA, USA)
8. The neuropathology of parkinsonism, Daniel P. Perl (New York, NY, USA)
9. Genetics, Yoshikuni Mizuno, Nobutaka Hattori and Hideki Mochizuki (Tokyo, Japan)
10. Imaging Parkinson's disease, David J. Brooks (London, UK)
11. Parkinson's disease: animal models, Ranjita Betarbet and J. Timothy Greenamyre (Atlanta, GA, USA)
Section 3 Clinical aspects
12. Scales to measure parkinsonism, Pablo Martinez-Martin and Esther Cubo (Madrid, Spain)
13. Motor symptoms in Parkinson's disease, Joohi Shahed and Joseph Jankovic (Houston, TX, USA)
14. Autonomic dysfunction in Parkinson's disease, Horacio Kaufmann and David S. Goldstein (New York, NY, and Bethesda, MD, USA)
15. Sleep in Parkinson syndromes, Claudia Trenkwalder and Birgit Högel (Kassel, Germany and Innsbruck, Austria)
16. Sensory symptoms in Parkinson's disease, Ruth Djaldetti and Eldad Melamed (Petah Tiqva and Tel Aviv, Israel)
17. Speech disorders in Parkinson's disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment, Lorraine Olson Ramig, Cynthia Fox and Shimon Sapir (New York, NY, Denver, CO, USA and Haifa, Israel)
18. Clinical features, pathophysiology and treatment of dementia associated with Parkinson's disease, Murat Emre (Istanbul, Turkey)
19. Disorders of mood and affect in Parkinson's disease, Daniel Weintraub and Matthew B. Stern (Philadelphia, PA, USA)
20. Neurobehavioral disorders in Parkinson's disease, Jose Martin Rabey (Ramat Aviv, Israel)
21. Early detection of Parkinson's disease, Catherine Gallagher and Erwin B. Montgomery Jr (Madison. WI, USA)
Section 4 Etiology
22. Mitochondria in the etiology of Parkinson's disease, Anthony H.V. Schapira (London, UK)
23. Iron as a trigger of neurodegeneration in Parkinson's disease, Andrzej Friedman, Jolanta Galazka-Friedman and Erika R. Bauminger (Warsaw, Poland and Jerusalem, Israel)
24. Oxidative stress and Parkinson's disease, Peter Jenner (London, UK)
25. Neurotrophic factors and Parkinson's disease, Don M. Gash, Yan Chen and Greg Gerhardt
26. Neuroinflammation and Parkinson's disease, Serge Przedborski (New York, NY, USA)
27. Excitotoxicity, Claire Henchcliffe and M. Flint Beal (New York, NY, USA)
28. Protein handling dysfunction in Parkinson's disease, Kevin St P. McNaught (New York, NY, USA)
29. Programmed cell death in Parkinson's disease, Robert E. Burke (New York, NY, USA)