Contents
Foreword

Section 1: Historical review and perspectives
Chapter 1: History of IBD (John A Walker-Smith)

Section 2: Pathogenesis (Theme Editor: Claudio Fiocchi)
Overview of IBD Pathogenesis (Claudio Fiocchi)
Inducing and conditioning factors
Chapter 2: Environment and epidemiology of IBD (John Marshall, Robert Hilsden)
Chapter 3: Genetics of IBD (Richard H Duerr)
Chapter 4: Microbial factors (Heiko C Rath)
Chapter 5: Intestinal permeability and mucosal defence (Jonathan Meddings, Peter R Gibson, Peter Tagkalidis)
Effector mechanisms of tissue damage
Chapter 6: The immune system in IBD (Francesco Pallone, Giovanni Monteleone, Ivan Monteleone, Livia Biancone)
Chapter 7: Non-immune cells in IBD (Yashwant R Mahida, B C McKaig)
Chapter 8: Soluble inflammatory mediators in IBD (John L Wallace, Cameron Bell)
Chapter 9: Cell adhesion molecules (Julian Panes, Miquel Sans, Josep Pique)
Chapter 10: Intestinal inflammation and enteric neuro-muscular function (Stephen M Collins)
Animal models: relevance to human IBD
Chapter 11: Animal models in IBD: Experimental and naturally occurring (Alan D Levine)
Implications for therapy
Chapter 12: Implications of pathophysiology for the clinical management of IBD (Fergus Shanahan)

Section 3: Diagnosis: A clinician's perspective (Theme Editor: Paul Rutgeerts)
Overview section (Stephen Hanauer)
Chapter 13: Ulcerative Colitis: Clinical presentation and diagnosis (Simon Travis, Derek P Jewell)
Chapter 14: Clinical presentation of Crohn's; Diagnosis of Crohn's (Alastair Forbes)
Chapter 15: Differential diagnosis and other forms of IBD (J Schölmerich, B Warren)
Chapter 16: Imaging the gut: Radiology (CI Bartram)
Chapter 17: Imaging the gut: endoscopy (Gert R D'Haens, Gert Van Assche, Filip Baert, Paul Rutgeerts)
Chapter 18: Histopathology of Crohn's disease and ulcerative colitis (Karel Geboes)
Chapter 19: New emerging techniques: An evidence-based perspective (Charles Bernstein)

Section 4: Medical Treatment (Theme Editor: Robert Lofberg)
Overview (Stefan Schreiber)
Chapter 20: Natural History and prognosis: an evidence-based approach (Antje Timmer)
Chapter 21: Assessing outcomes in clinical trials (E Jan Irvine)
Chapter 22: Primer of drug therapies available in IBD (Remo Panacionne, Richard Fedorak)
Chapter 23: Induction of remission in Crohn's disease (Eduard Stange)
Chapter 24: Maintenance of remission in patients with Crohn's disease (Alan Thomson, G Wild)
Chapter 25: Induction of remission in ulcerative colitis (A Hillary Steinhart)
Chapter 26: The management of fulminant ulcerative colitis (A Hillary Steinhart)
Chapter 27: Maintenance and remission of active ulcerative colitis (Massimo Campieri, Fernando Rizzello, Paulo Gionchetti)
Selected topics in therapy
Chapter 28: Biological therapies of IBD (Sander van Deventer)
Chapter 29: Pharmacogenetics and IBD (Jean-Frédéric Colombel, Nicolas Ferrari, Ian Arnott, Christian Libersa, Jack Satsangi)
Chapter 30: Nutrition and diet (Miguel Gassull)
Chapter 31: Probiotics (Paulo Gionchetti , K M Lammers, Fernando Rizzello, A Venturi, C Amadini, Massimo Campieri)

Section Five: Surgical treatment (John Pemberton)
Overview section (John Nicholls)
Chapter 32: Surgical treatment of chronic ulcerative colitis (Peter M Sagar, John H Pemberton)
Chapter 33: Surgical treatment of Crohn's Disease (Oliver Jones, Neil Mortensen)
Chapter 34: Minimally invasive surgery in patients with IBD (James Francombe, Michael Hershman)
Chapter 35: Stoma management (John G Williams)
Chapter 36: Pouch dysfunction and pouchitis (Mark W Thompson-Fawcett , Oliver Jones)

Section 6: Complications and clinical problems in IBD (Jean-Frédéric Colombel)
Overview section (Jack Satsangi)
Chapter 37: Abdominal fistulizing Crohn's disease (Reuben West, Nigel Scott)
Chapter 38: Cancer risk in IBD (Steven Itzkowitz, Thomas Ullman)
Chapter 39: Hepatobiliary disease (Roger Chapman)
Chapter 40: Osteoporosis associated with IBD (Juliet Compston)
Chapter 41: Extraintestinal manifestations: eyes, skin and joints (Timothy Orchard)
Chapter 42: Thrombosis and IBD (Keith Leiper, Jonathan Rhodes)
Chapter 43: Anemia in IBD (Christoph Gasche)
Chapter 44: Extra-intestinal manifestations of IBD: others (Matthieu Allez)
Chapter 45: IBD in childhood (Anne Griffiths)
Chapter 46: IBD and pregnancy (Philippe Marteau)
Chapter 47: IBD in the elderly (Simon Travis)
Chapter 48: Patient FAQs (A Mandal, John Mayberry)
Chapter 49: Quality of life issues for the IBD patient (Gabriele Moser, Michael Oberwalder, Steven Wexner)